10 results on '"Kenji Hirano"'
Search Results
2. Clinical outcomes of secondary gastroduodenal self-expandable metallic stent placement by stent-in-stent technique for malignant gastric outlet obstruction
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Kazuhiko Koike, Takashi Sasaki, Saburo Matsubara, Suguru Mizuno, Kenji Hirano, Toshihiko Arizumi, Dai Mohri, Naminatsu Takahara, Hiroshi Yagioka, Yousuke Nakai, Naoki Sasahira, Nobuo Toda, Yukiko Ito, Hirofumi Kogure, Natsuyo Yamamoto, Tsuyoshi Hamada, Minoru Tada, Osamu Togawa, and Hiroyuki Isayama
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Gastroenterology ,Stent ,Gastric outlet obstruction ,equipment and supplies ,medicine.disease ,Surgery ,surgical procedures, operative ,Gastrointestinal perforation ,Self-expandable metallic stent ,Pancreatic cancer ,medicine ,Retrospective analysis ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Major complication ,Radiology ,business ,Median survival - Abstract
Background and Aim To evaluate the efficacy and safety of secondary gastroduodenal stent placement after first stent dysfunction for malignant gastric outlet obstruction. Methods We conducted a retrospective analysis to investigate the efficacy and safety of secondary stent-in-stent gastroduodenal stent placement. Results Among 260 patients who had been treated with first gastroduodenal stent placement for malignant gastric outlet obstruction, 29 patients (11.2%) were treated with secondary gastroduodenal stent placement because of first stent dysfunction. Pancreatic cancer was the major primary cancer (55.2%). A WallFlex duodenal stent was the most frequently inserted stent both as a first stent (75.9%) and as a secondary stent (62.1%). There were 22 patients (75.9%) that received gastroduodenal stents at the bending site (supraduodenal angle or infraduodenal angle). Technical and clinical success rates were 100% and 86.2%, respectively. Median eating period was 3.0 months, and median survival time was 3.5 months. As for related complications, gastrointestinal perforation, insufficient stent expansion, tumor ingrowth, tumor overgrowth, and cholangitis were experienced in 13.8% (four cases), 6.9% (two cases), 6.9% (two cases), 3.4% (one case), and 3.4% (one case), respectively. Conclusion Secondary gastroduodenal stent placement might be effective for managing first stent dysfunction in malignant gastric outlet obstruction. However, gastrointestinal perforation was the major complication.
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- 2014
3. Role of endoscopic ultrasonography in pancreatic cystic neoplasms: Where do we stand and where will we go?
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Takao Itoi, Hiroyuki Isayama, Kazuhiko Koike, Hirofumi Kogure, Yousuke Nakai, Takashi Sasaki, Kenji Hirano, Natsuyo Yamamoto, and Minoru Tada
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Endoscopic ultrasound ,medicine.medical_specialty ,Endoscopic retrograde cholangiopancreatography ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,Magnetic resonance imaging ,Endoscopic ultrasonography ,medicine.disease ,digestive system diseases ,Clinical trial ,medicine.anatomical_structure ,medicine ,Radiology, Nuclear Medicine and imaging ,Cyst ,Radiology ,Medical diagnosis ,Pancreas ,business - Abstract
We increasingly encounter pancreatic cystic neoplasms (PCN) in clinical practice and the differential diagnoses vary widely from benign to malignant. There is no 'one and only' diagnostic procedure for PCN. Multiple modalities including computed tomography, magnetic resonance imaging, endoscopic retrograde cholangiopancreatography and endoscopic ultrasound (EUS) are widely used, but EUS has the advantage of anatomical proximity to the pancreas and upper gastrointestinal tract. In addition, EUS-guided fine-needle aspiration (EUS-FNA) provides both cytological evaluation and cyst fluid analysis. Although the role of EUS-FNA for PCN is established, the sensitivity of cytology is low and cyst fluid analysis is only useful for differentiation between mucinous and non-mucinous cysts. Recently, novel through-the-needle imaging under EUS-FNA, such as confocal laserendomicroscopy, is expected to attribute to a better diagnostic yield. Moreover, feasibility of cyst ablation has been reported and the role of EUS has expanded from diagnosis to treatment. However, clinical impact of cyst ablation in terms of safety, efficacy and cost-effectiveness should be validated further. In summary, EUS and EUS-guided intervention does and will play a central role in the management of PCN from surveillance to treatment, but many clinical questions remain unanswered, which warrants well-designed prospective clinical trials.
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- 2013
4. Estimation and comparison of cumulative incidences of biliary self-expandable metallic stent dysfunction accounting for competing risks
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Takeshi Tsujino, Yukiko Ito, Kazuhiko Koike, Kazumichi Kawakubo, Kenji Hirano, Osamu Togawa, Nobuo Toda, Yousuke Nakai, Takashi Sasaki, Suguru Mizuno, Tsuyoshi Hamada, Naoki Sasahira, Hiroyuki Isayama, Natsuyo Yamamoto, Hirofumi Kogure, and Minoru Tada
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Significant difference ,Gastroenterology ,Stent ,Competing risks ,Surgery ,Self-expandable metallic stent ,Female patient ,Medicine ,Radiology, Nuclear Medicine and imaging ,Cumulative incidence ,business ,Survival analysis - Abstract
Background Self-expandable metallic stent (SEMS) placement is widely carried out for distal malignant biliary obstruction, and survival analysis is used to evaluate the cumulative incidences of SEMS dysfunction (e.g. the Kaplan–Meier [KM] method and the log–rank test). However, these statistical methods might be inappropriate in the presence of ‘competing risks’ (here, death without SEMS dysfunction), which affects the probability of experiencing the event of interest (SEMS dysfunction); that is, SEMS dysfunction can no longer be observed after death. A competing risk analysis has rarely been done in studies on SEMS. Patients and Methods We introduced the concept of a competing risk analysis and illustrated its impact on the evaluation of SEMS outcomes using hypothetical and actual data. Our illustrative study included 476 consecutive patients who underwent SEMS placement for unresectable distal malignant biliary obstruction. Results A significant difference between cumulative incidences of SEMS dysfunction in male and female patients via theKM method (P = 0.044 by the log–rank test) disappeared after applying a competing risk analysis (P = 0.115 by Gray's test). In contrast, although cumulative incidences of SEMS dysfunction via the KM method were similar with and without chemotherapy (P = 0.647 by the log–rank test), cumulative incidence of SEMS dysfunction in the non-chemotherapy group was shown to be significantly lower (P = 0.031 by Gray's test) in a competing risk analysis. Conclusion Death as a competing risk event needs to be appropriately considered in estimating a cumulative incidence of SEMS dysfunction, otherwise analytical results may be biased.
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- 2013
5. Novel antireflux covered metal stent for recurrent occlusion of biliary metal stents: A pilot study
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Hirofumi Kogure, Takashi Sasaki, Hiroyuki Isayama, Natsuyo Yamamoto, Yousuke Nakai, Kenji Hirano, Minoru Tada, Kazuhiko Koike, Tsuyoshi Hamada, Osamu Togawa, Kazumichi Kawakubo, Yukiko Ito, Takeshi Tsujino, and Naoki Sasahira
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medicine.medical_specialty ,Palliative care ,business.industry ,medicine.medical_treatment ,Technical success ,Gastroenterology ,Reflux ,Stent ,medicine.disease ,Surgery ,Bile reflux ,Occlusion ,medicine ,Radiology, Nuclear Medicine and imaging ,In patient ,Radiology ,business ,Prospective cohort study - Abstract
Background Feasibility of antireflux metal stent (ARMS), designed to prevent duodenobiliary reflux, was reported in patients with distal malignant biliary obstruction. In this prospective pilot study, we aimed to evaluate a newly designed ARMS as a reintervention for self-expandable metallic stent (SEMS) occlusion believed to be caused by duodenobiliary reflux. Patients and Methods Patients with non-resectable distal malignant biliary obstruction were included in whom a prior SEMS was occluded as a result of sludge or food impaction between March 2010 and January 2012 at two Japanese tertiary referral centers. The occluded SEMS were endoscopically removed, if possible, and subsequently replaced by a newly designed ARMS. We evaluated the technical success rate and complications of ARMS and compared the time to occlusion of ARMS with that of prior SEMS. Results A total of 13 patients were included. ARMS was successfully placed in all patients in a single procedure. No procedure-related complications were identified. ARMS occlusion occurred in two patients (15%), the causes of which were sludge in one patient and unknown in the other. ARMS migration occurred in four patients (31%). ARMS patency time was significantly longer than that of prior SEMS (median, not available vs 58 days; P = 0.039). Conclusions This newly designed ARMS is a technically feasible, safe, and effective reintervention for SEMS occlusion as a result of sludge or food impaction. An anti-migration mechanism to improve the outcomes of ARMS should be considered.
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- 2013
6. Feasibility of a new self-expandable metallic stent for patients with malignant colorectal obstruction
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Yutaka Yamaji, Hiroyuki Isayama, Naoki Sasahira, Yousuke Nakai, Shuntaro Yoshida, Kenji Hirano, Takashi Sasaki, Hirofumi Kogure, Natsuyo Yamamoto, Hirotsugu Watabe, Masao Omata, Tsuyoshi Hamada, Kazuhiko Koike, Minoru Tada, Yoko Yashima, Yukiko Ito, and Kazumichi Kawakubo
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medicine.medical_specialty ,Palliative care ,medicine.diagnostic_test ,Impaction ,business.industry ,Incidence (epidemiology) ,medicine.medical_treatment ,Gastroenterology ,Stent ,Enteral administration ,Endoscopy ,Surgery ,Stoma ,Self-expandable metallic stent ,medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,business - Abstract
Aim Stent migration due to peristalsis of the colon is one of the unresolved complications of colonic self-expandable metallic stent (SEMS) placement. Axial force (AF), a recovery force of the stent to a straight position after bending, has been considered a factor influencing the conformability of the digestive tract. An uncovered SEMS (Niti-S Enteral Colonic Uncovered Stent, D-type; Taewoong, Inc., Gimpo, South Korea) with improved conformability is considered to decrease migration. Methods Thirty three consecutive patients with symptomatic colorectal obstruction between March 2006 and December 2011 underwent endoscopic stent placement for palliation to estimate the efficacy and safety of Niti-S stents prospectively in four tertiary referral centers. Results Technical and clinical success rates were 100% and 97%, respectively. Seventeen patients had the following complications: ingrowth (n = 6), overgrowth (n = 1), collapse of the SEMS (n = 1), stool impaction (n = 2), migration (n = 1), bleeding (n = 3), and tenesmus (n = 3). The patient with migration had no recurrent symptoms until death. Of these 17 patients, 10 required re-interventions. Seven patients underwent an additional SEMS implantation. One patient underwent surgery for stoma creation. Two patients had stool impaction, and they underwent endoscopic cleaning. The median duration of patency was 347.0 ± 65.5 days. The mean survival time after stent insertion was 240.1 ± 39.9 days. Conclusion The new SEMS effectively relieves malignant colorectal obstruction. Good conformability, according to the very low AF, may contribute to the low incidence of migration.
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- 2012
7. <scp>J</scp> apanese multicenter estimation of wallflex duodenal stent for unresectable malignant gastric outlet obstruction
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Nobuo Toda, Kazuhiko Koike, Saburo Matsubara, Hiroyuki Isayama, Yukiko Ito, Iruru Maetani, Naoki Sasahira, Suguru Mizuno, Minoru Tada, Kazumichi Kawakubo, Takeshi Tsujino, Takashi Sasaki, Natsuyo Yamamoto, Hiroshi Yagioka, Hirofumi Kogure, Yousuke Nakai, and Kenji Hirano
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Male ,medicine.medical_specialty ,Duodenum ,medicine.medical_treatment ,Perforation (oil well) ,Contrast Media ,Prosthesis Design ,Statistics, Nonparametric ,Postoperative Complications ,Japan ,Stomach Neoplasms ,Gastroscopy ,Alloys ,Humans ,Medicine ,Fluoroscopy ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Survival rate ,Aged ,Retrospective Studies ,Aged, 80 and over ,Cholangiopancreatography, Endoscopic Retrograde ,medicine.diagnostic_test ,Gastric Outlet Obstruction ,business.industry ,Gastroenterology ,Stent ,Gastric outlet obstruction ,Retrospective cohort study ,Middle Aged ,equipment and supplies ,medicine.disease ,Confidence interval ,Surgery ,Survival Rate ,Treatment Outcome ,surgical procedures, operative ,medicine.anatomical_structure ,Female ,Stents ,Radiology ,business - Abstract
Aim This retrospective study estimated the efficacy and safety of the WallFlex duodenal stent for malignant gastric outlet obstruction (GOO) in Japan. Methods Forty-two consecutive patients with symptomatic malignant GOO were treated using WallFlex duodenal stents between January 2010 and October 2010. Results The technical and clinical success rates were 100% and 83.3%, respectively.The median gastric outlet obstruction scoring system increased significantly, from 0 to 2, after stent placement (P
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- 2012
8. Predictive factors of solid food intake in patients with malignant gastric outlet obstruction receiving self-expandable metallic stents for palliation
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Suguru Mizuno, Naoki Sasahira, Yoko Yashima, Natsuyo Yamamoto, Osamu Togawa, Yousuke Nakai, Kenji Hirano, Yukiko Ito, Masao Omata, Minoru Tada, Takeshi Tsujino, Nobuo Toda, Kazumichi Kawakubo, Kazuhiko Koike, Hiroyuki Isayama, Hirofumi Kogure, and Takashi Sasaki
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medicine.medical_specialty ,business.industry ,Gastroenterology ,Gastric outlet obstruction ,Retrospective cohort study ,Odds ratio ,medicine.disease ,Surgery ,Self-expandable metallic stent ,Solid food ,Internal medicine ,Ascites ,medicine ,Radiology, Nuclear Medicine and imaging ,In patient ,medicine.symptom ,business ,Median survival - Abstract
Aim: As for self-expandable metallic stents (SEMS) for malignant gastric outlet obstruction (GOO), some predictive factors of stent patency have been reported, although re-canalization of GOO by SEMS does not necessarily lead to favorable food intake. Therefore, we analyzed the predictive factors of oral food intake following SEMS placement. Methods: A total of 97 consecutive patients in whom SEMS were placed for malignant GOO in five hospitals were included in this retrospective study. Clinical outcomes and predictive factors influencing solid food intake were analyzed. Results: The technical and clinical success rates were 97.9% and 87.6%, respectively. The mean gastric outlet obstruction scoring system (GOOSS) improved from 0.39 to 2.24 after SEMS placement (P
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- 2011
9. EXPERIENCES OF BILIARY INTERVENTIONS USING SHORT DOUBLE-BALLOON ENTEROSCOPY IN PATIENTS WITH ROUX-EN-Y ANASTOMOSIS OR HEPATICOJEJUNOSTOMY
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Hirofumi Kogure, Hiroyuki Isayama, Masao Omata, Atsuo Yamada, Kenji Hirano, Minoru Tada, Naoki Sasahira, Takeshi Tsujino, and Takao Kawabe
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Enteroscopy ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Gastroenterology ,Anastomosis ,Roux-en-Y anastomosis ,Surgery ,Endoscopy ,Balloon dilations ,Double-balloon enteroscopy ,Balloon dilation ,medicine ,Radiology, Nuclear Medicine and imaging ,Gastrectomy ,Radiology ,business - Abstract
Background: The efficacy of double-balloon enteroscopy (DBE) for biliary interventions has been shown in patients with surgical anatomy. However, the use of available endoscopic retrograde cholangiography accessories during this procedure is limited because of the length of the conventional instrument (200 cm). The aim of this study was to evaluate the feasibility of short DBE for managing biliary disorders in patients with a Roux-en-Y gastrectomy or hepaticojejunostomy (HJ). Patients and Methods: Using a short enteroscope (152 cm) and commercially available endoscopic retrograde cholangiography accessories, biliary interventions were performed in six patients with Roux-en-Y reconstruction or HJ anastomosis. Results: A total of 12 biliary interventions were performed; balloon dilations of the HJ anastomosis or intrahepatic ducts (four patients), nasobiliary drainages (three patients), bile duct stone removal after endoscopic papillary large balloon dilation with or without small sphincterotomy (two patients), and a biliary stent placement (one patient). One patient showed retroperitoneal air following endoscopic papillary large balloon dilation, but recovered conservatively. Conclusions: Biliary interventions via DBE using a short enteroscope are feasible in patients with surgical anatomy.
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- 2010
10. ENDOSCOPIC MANAGEMENT OF BILIOCUTANEOUS FISTULA AFTER PERCUTANEOUS RADIOFREQUENCY ABLATION THERAPY FOR HEPATOCELLULAR CARCINOMA
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Takao Kawabe, Kenji Hirano, Shuichiro Shiina, Hiroyuki Isayama, Naoki Sasahira, Masao Omata, Ryosuke Tateishi, Minoru Tada, Haruhiko Yoshida, and Takeshi Tsujino
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Billroth II ,medicine.medical_specialty ,Cirrhosis ,Percutaneous ,business.industry ,Radiofrequency ablation ,medicine.medical_treatment ,Fistula ,Gastroenterology ,medicine.disease ,digestive system diseases ,law.invention ,Catheter ,law ,Hepatocellular carcinoma ,medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,Hepatectomy ,business - Abstract
Our patient was a 70-year-old man with hepatocellular carcinoma (HCC) and liver cirrhosis (Child-Pugh B). He had a history of distal gastrectomy with Billroth II reconstruction for duodenal ulcer and hepatectomy for HCC. One month after percutaneous radiofrequency ablation (RFA) for recurrent HCC, biliocutaneous fistula was observed. The cholangiogram demonstrated leakage of contrast material from an intrahepatic duct into the fistula, and a nasobiliary catheter was placed. Subsequently, the discharge of bile steadily decreased and stopped. Follow-up cholangiogram revealed no evidence of bile leakage. Biliocutaneous fistula is an extremely rare complication after percutaneous RFA, and the present case report suggests that endoscopic drainage is the first-line therapy for bile leaks after RFA.
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- 2010
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