1. Maternal-Fetal Proinflammatory Cytokine Gene Polymorphism and Preterm Birth.
- Author
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Yılmaz, Yaprak, Verdi, Hasibe, Taneri, Ayşe, Yazıcı, Ayse Canan, Ecevit, Ayşe Nur, Karakaş, Nazmi Mutlu, Tarcan, Aylin, Haberal, Ali, Ozbek, Namık, and Atac, Fatma Belgin
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CYTOKINES , *PREMATURE labor , *NEWBORN infant physiology , *GENETIC polymorphisms , *CORD blood , *IMMUNOLOGY of inflammation , *GENE frequency , *NEONATAL necrotizing enterocolitis - Abstract
Association between maternal-fetal proinflammatory cytokine genotype and preterm birth was studied. Isolated genomic DNA from maternal and cord blood samples of 100 preterm and 101 term labors were used for TNFα (-238G/A, -308G/A), IL-1α (4845G/T), and IL-1β (-511C/T) genotyping. TNFα -238 GA genotype in term neonates was significantly higher than the premature neonates ( p<0.05). Maternal-fetal TNFα -238 heterozygosity was associated with term labor ( p<0.05). TNFα -308 GA and AA genotypes were associated with term labor (mothers and neonates, respectively; p<0.05 and p<0.001). The incidence of term labor was significantly increased in TNFα -308 GA genotype. If a -308GA carrier has a fetus with GG genotype, the incidence of preterm labor increases ( p<0.01). The 4845 T allele was significantly higher in preterm mothers and neonates ( p<0.001 and p<0.001). The effect of maternal-fetal genotype for the pregnancy outcome reveals that maternal 4845GG and GT genotypes increase term labor incidence, whereas fetal 4845 TT genotype was a significant independent risk factor for preterm birth ( p<0.01). IL-1β -511 TT genotype was significantly higher in preterm neonates. The preterm labor risk was significantly increased in maternal -511 TT genotype and fetal CT genotypes, whereas with maternal -511 CT or TT genotypes or a -511 TT fetus, the incidence of term pregnancy increases ( p<0.01). [ABSTRACT FROM AUTHOR]
- Published
- 2012
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