6 results on '"Kang, Xiong"'
Search Results
2. Radiotherapy-induced enrichment of EGF-modified doxorubicin nanoparticles enhances the therapeutic outcome of lung cancer
- Author
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Jing Wang, Yan Zhang, GuangPeng Zhang, Li Xiang, HaoWen Pang, Kang Xiong, Yun Lu, JianMei Li, Jie Dai, Sheng Lin, and ShaoZhi Fu
- Subjects
doxorubicin ,nanoparticles ,egf ,lung cancer ,radiotherapy ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Chemotherapy is the primary treatment for advanced non-small-cell lung cancer (NSCLC). However, related dose-dependent toxicity limits its clinical use. Therefore, it is necessary to explore new strategies for improving the clinical outcomes while reducing the side effects of chemotherapy in the treatment of NSCLC. In this study, we designed and synthesized epidermal growth factor (EGF)-modified doxorubicin nanoparticles (EGF@DOX-NPs) that selectively targets the epidermal growth factor receptor (EGFR) overexpressed in lung tumor cells. When administered in combination with low-dose X-ray radiotherapy (RT), the NPs preferentially accumulated at the tumor site due to radiation-induced outburst of the local intra-tumoral blood vessels. Compared with DOX alone, EGF@DOX-NPs significantly decreased the viability and migration and enhanced the apoptosis rates of tumor cells in vitro. Also, the EGF@DOX-NPs significantly inhibited tumor growth in vivo, increasing the survival of the tumor-bearing mice without apparent systemic toxic effects through RT-induced aggregation. The tumor cell proliferation was greatly inhibited in the RT + EGF@DOX-NPs group. Contrarily, the apoptosis of tumor cells was significantly higher in this group. These results confirm the promising clinical application of radiotherapy in combination with EGF@DOX-NPs for lung cancer treatment.
- Published
- 2022
- Full Text
- View/download PDF
3. Self-assembled dihydroartemisinin nanoparticles as a platform for cervical cancer chemotherapy
- Author
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Yun Lu, Qian Wen, Jia Luo, Kang Xiong, ZhouXue Wu, BiQiong Wang, Yue Chen, Bo Yang, and ShaoZhi Fu
- Subjects
dihydroartemisinin ,mpeg-pcl ,nanoparticles ,cervical cancer ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Dihydroartemisinin (DHA) is a potent anti-cancer drug that has limited clinical applications due to poor water solubility and low bioavailability. We designed a biodegradable poly(ethylene glycol) methyl ether-poly(ε-caprolactone) (MPEG-PCL) micelle carrier for DHA using the self-assembly method. The DHA/MPEG-PCL nanoparticles were spherical with an average particle size of 30.28 ± 0.27 nm, and released the drug in a sustained manner in aqueous solution. The drug-loaded nanoparticles showed dose-dependent toxicity in HeLa cells by inducing cycle arrest and apoptosis. Furthermore, compared to free DHA, the DHA/MPEG-PCL nanoparticles showed higher therapeutic efficacy and lower toxicity in vivo, and significantly inhibited tumor growth and prolonged the survival of tumor-bearing nude mice. In addition, the tumor tissues of the DHA/MPEG-PCL-treated mice showed a marked decline in the in situ expression of proliferation and angiogenesis markers. Taken together, the self-assembled DHA/MPEG-PCL nanoparticles are a highly promising delivery system for targeted cancer treatment.
- Published
- 2020
- Full Text
- View/download PDF
4. Curcumin nanoparticles incorporated in PVA/collagen composite films promote wound healing
- Author
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QingQing Leng, Yue Li, XianLun Pang, BiQiong Wang, ZhouXue Wu, Yun Lu, Kang Xiong, Ling Zhao, Ping Zhou, and ShaoZhi Fu
- Subjects
curcumin ,nanoparticles ,collagen ,pva ,composite film ,wound healing ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Skin repair remains a common problem in plastic surgery. Wound dressing plays an important role in promoting local skin healing and has been widely studied. This study aimed to manufacture a composite film (CPCF) containing curcumin nanoparticles, collagen, and polyvinyl alcohol (PVA) to effectively promote the healing of skin wounds. Sustained drug release from the composite film provides long-term protection and treatment for skin wounds. Both antibacterial property and good histocompatibility of the CPCF were examined by analyzing antibacterial activity and cytotoxicity to validate its applicability for wound management. Moreover, in vivo studies proved that the CPCF had a rapid healing rate of 98.03%±0.79% and mature epithelialization on day 15 after surgery. Obvious hair follicles and earlier re-epithelialization was also noticed in the CPCF group using H&E staining. The result of Masson’s trichrome staining confirmed that CPCF could promote the formation of collagen fibers. In summary, CPCF may be promising as a wound dressing agent in wound management owing to its rapid wound-healing effects.
- Published
- 2020
- Full Text
- View/download PDF
5. Self-assembled dihydroartemisinin nanoparticles as a platform for cervical cancer chemotherapy
- Author
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Bo Yang, Jia Luo, BiQiong Wang, Yue Chen, Yun Lu, ShaoZhi Fu, Qian Wen, Kang Xiong, and ZhouXue Wu
- Subjects
cervical cancer ,medicine.medical_treatment ,Uterine Cervical Neoplasms ,Pharmaceutical Science ,Nanoparticle ,Apoptosis ,Biocompatible Materials ,02 engineering and technology ,Pharmacology ,030226 pharmacology & pharmacy ,Polyethylene Glycols ,Mice ,dihydroartemisinin ,chemistry.chemical_compound ,Drug Delivery Systems ,0302 clinical medicine ,media_common ,Cervical cancer ,Drug Carriers ,Cell Cycle ,General Medicine ,021001 nanoscience & nanotechnology ,Artemisinins ,Treatment Outcome ,Original Article ,Female ,0210 nano-technology ,Research Article ,Drug ,Polyesters ,media_common.quotation_subject ,Mice, Nude ,Dihydroartemisinin ,RM1-950 ,Self assembled ,Antimalarials ,03 medical and health sciences ,parasitic diseases ,medicine ,Animals ,Humans ,Chemotherapy ,medicine.disease ,Bioavailability ,chemistry ,nanoparticles ,Therapeutics. Pharmacology ,mpeg-pcl ,Ethylene glycol ,HeLa Cells - Abstract
Dihydroartemisinin (DHA) is a potent anti-cancer drug that has limited clinical applications due to poor water solubility and low bioavailability. We designed a biodegradable poly(ethylene glycol) methyl ether-poly(ε-caprolactone) (MPEG-PCL) micelle carrier for DHA using the self-assembly method. The DHA/MPEG-PCL nanoparticles were spherical with an average particle size of 30.28 ± 0.27 nm, and released the drug in a sustained manner in aqueous solution. The drug-loaded nanoparticles showed dose-dependent toxicity in HeLa cells by inducing cycle arrest and apoptosis. Furthermore, compared to free DHA, the DHA/MPEG-PCL nanoparticles showed higher therapeutic efficacy and lower toxicity in vivo, and significantly inhibited tumor growth and prolonged the survival of tumor-bearing nude mice. In addition, the tumor tissues of the DHA/MPEG-PCL-treated mice showed a marked decline in the in situ expression of proliferation and angiogenesis markers. Taken together, the self-assembled DHA/MPEG-PCL nanoparticles are a highly promising delivery system for targeted cancer treatment.
- Published
- 2020
6. Curcumin nanoparticles incorporated in PVA/collagen composite films promote wound healing
- Author
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Ping Zhou, ZhouXue Wu, Yue Li, Kang Xiong, XianLun Pang, Yun Lu, ShaoZhi Fu, Ling Zhao, BiQiong Wang, and QingQing Leng
- Subjects
Male ,collagen ,Staphylococcus aureus ,medicine.medical_specialty ,Materials science ,Composite number ,Pharmaceutical Science ,Nanoparticle ,Biocompatible Materials ,wound healing ,Composite film ,Microbial Sensitivity Tests ,RM1-950 ,02 engineering and technology ,030226 pharmacology & pharmacy ,Epithelium ,Rats, Sprague-Dawley ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Escherichia coli ,pva ,medicine ,Animals ,curcumin ,Skin ,Skin repair ,integumentary system ,General Medicine ,021001 nanoscience & nanotechnology ,Bandages ,Anti-Bacterial Agents ,Rats ,composite film ,Drug Liberation ,Plastic surgery ,chemistry ,Polyvinyl Alcohol ,Wound dressing ,Curcumin ,nanoparticles ,Therapeutics. Pharmacology ,0210 nano-technology ,Wound healing ,Hair Follicle ,Research Article ,Biomedical engineering - Abstract
Skin repair remains a common problem in plastic surgery. Wound dressing plays an important role in promoting local skin healing and has been widely studied. This study aimed to manufacture a composite film (CPCF) containing curcumin nanoparticles, collagen, and polyvinyl alcohol (PVA) to effectively promote the healing of skin wounds. Sustained drug release from the composite film provides long-term protection and treatment for skin wounds. Both antibacterial property and good histocompatibility of the CPCF were examined by analyzing antibacterial activity and cytotoxicity to validate its applicability for wound management. Moreover, in vivo studies proved that the CPCF had a rapid healing rate of 98.03%±0.79% and mature epithelialization on day 15 after surgery. Obvious hair follicles and earlier re-epithelialization was also noticed in the CPCF group using H&E staining. The result of Masson’s trichrome staining confirmed that CPCF could promote the formation of collagen fibers. In summary, CPCF may be promising as a wound dressing agent in wound management owing to its rapid wound-healing effects.
- Published
- 2020
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