Search

Your search keyword '"WANSHUI SHAN"' showing total 2 results
Start Over Author "WANSHUI SHAN" Journal drug delivery
2 results on '"WANSHUI SHAN"'

1. Immunotherapeutic effect of BCG-polysaccharide nucleic acid powder on Mycobacterium tuberculosis-infected mice using microneedle patches

Author

Qinying Yan, Houming Liu, Zhigang Cheng, Yun Xue, Zhide Cheng, Xuyong Dai, Wanshui Shan, and Fan Chen

Subjects
immunotherapy, bcg-psn, tuberculosis, powder, microneedle patch, Therapeutics. Pharmacology, RM1-950
Abstract

Polysaccharide nucleic acid fractions of bacillus Calmette–Guérin, termed BCG-PSN, have traditionally been used as immunomodulators in the treatment of dermatitis and allergic diseases. While the sales of injectable BCG-PSN have shown steady growth in recent years, no reports of using BCG-PSN powder or its immunotherapeutic effects exist. Here, BCG-PSN powder was applied directly to the skin to evaluate the immunotherapeutic effects on mice infected with Mycobacterium tuberculosis (MTB). In total, 34 μg of BCG-PSN powder could be loaded into a microneedle patch (MNP). Mice receiving BCG-PSN powder delivered via MNP exhibited significantly increased IFN-γ and TNF-α production in peripheral blood CD4 + T cells and improved pathological changes in their lungs and spleens compared to control group mice. The immunotherapeutic effect of BCG-PSN powder delivered via MNP was better than that delivered via intramuscular injection to some extent. Furthermore, MNPs eliminate the side effects of syringes, and this study demonstrated that BCG-PSN can be clinically administrated in powder form.

Published
2017
Full Text
View/download PDF

2. Immunotherapeutic effect of BCG-polysaccharide nucleic acid powder on Mycobacterium tuberculosis-infected mice using microneedle patches

Author

Zhigang Cheng, Wanshui Shan, Yun Xue, Zhide Cheng, Qinying Yan, Houming Liu, Fan Chen, and Xuyong Dai

Subjects
CD4-Positive T-Lymphocytes, microneedle patch, Tuberculosis, medicine.medical_treatment, Pharmaceutical Science, RM1-950, 02 engineering and technology, powder, Polysaccharide, complex mixtures, Injections, Intramuscular, Mycobacterium tuberculosis, Interferon-gamma, Mice, 03 medical and health sciences, 0302 clinical medicine, Adjuvants, Immunologic, Polysaccharides, Nucleic Acids, medicine, Animals, 030212 general & internal medicine, BCG-PSN, Lung, chemistry.chemical_classification, Bacillus (shape), Mice, Inbred BALB C, biology, Tumor Necrosis Factor-alpha, Chemistry, General Medicine, Immunotherapy, 021001 nanoscience & nanotechnology, medicine.disease, biology.organism_classification, Mycobacterium bovis, Virology, tuberculosis, Needles, Nucleic acid, Cattle, Female, Therapeutics. Pharmacology, Powders, 0210 nano-technology, Tuberculosis, Bovine, Research Article
Abstract

Polysaccharide nucleic acid fractions of bacillus Calmette–Guérin, termed BCG-PSN, have traditionally been used as immunomodulators in the treatment of dermatitis and allergic diseases. While the sales of injectable BCG-PSN have shown steady growth in recent years, no reports of using BCG-PSN powder or its immunotherapeutic effects exist. Here, BCG-PSN powder was applied directly to the skin to evaluate the immunotherapeutic effects on mice infected with Mycobacterium tuberculosis (MTB). In total, 34 μg of BCG-PSN powder could be loaded into a microneedle patch (MNP). Mice receiving BCG-PSN powder delivered via MNP exhibited significantly increased IFN-γ and TNF-α production in peripheral blood CD4 + T cells and improved pathological changes in their lungs and spleens compared to control group mice. The immunotherapeutic effect of BCG-PSN powder delivered via MNP was better than that delivered via intramuscular injection to some extent. Furthermore, MNPs eliminate the side effects of syringes, and this study demonstrated that BCG-PSN can be clinically administrated in powder form.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results