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Your search keyword '"Khaled Shalaby"' showing total 4 results
Start Over Author "Khaled Shalaby" Journal drug development and industrial pharmacy
4 results on '"Khaled Shalaby"'

1. EthoLeciplex: a new tool for effective cutaneous delivery of minoxidil

Author

Mohammed Elmowafy, Khaled Shalaby, Nabil K. Alruwaili, Mohammed H. Elkomy, Ameeduzzafar Zafar, Ghareb M. Soliman, Ayman Salama, and Elsaied H. Barakat

Subjects
Pharmacology, Ethanol, Cetrimonium, Organic Chemistry, Drug Discovery, Liposomes, Minoxidil, Pharmaceutical Science, Particle Size, Administration, Cutaneous, Phospholipids, Skin
Abstract

This work designates EthoLeciplex, a vesicular system consisting of phospholipid, CTAB, ethanol and water, as an innovative vesicular system for cutaneous/transfollicular minoxidil (MX) delivery. MX-loaded EthoLeciplex was fabricated by one-step fabrication process. Formulations were designed to study the effects of drug/phospholipid ratio, CTAB/phospholipid ratio, and ethanol concentration on vesicular size, PDI, surface charge and EE%. The optimized formulation was characterized by

Published
2022

2. Development and machine-learning optimization of mucoadhesive nanostructured lipid carriers loaded with fluconazole for treatment of oral candidiasis

Author

Mohammed H. Elkomy, Ameeduzzafar Zafar, Khaled Shalaby, Hussein M. Eid, Naveed Ahmad, Mohammed Elmowafy, and Ahmed F. Azmy

Subjects
Pharmaceutical Science, 02 engineering and technology, 030226 pharmacology & pharmacy, Machine Learning, Chitosan, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Candidiasis, Oral, Drug Discovery, medicine, Animals, Particle Size, Candida albicans, Fluconazole, Pharmacology, Drug Carriers, biology, business.industry, Organic Chemistry, 021001 nanoscience & nanotechnology, biology.organism_classification, Lipids, Nanostructures, chemistry, Nanoparticles, Rabbits, 0210 nano-technology, business, Biomedical engineering, medicine.drug
Abstract

The aim of this work was to prepare and optimize mucoadhesive nanostructured lipid carrier (NLC) impregnated with fluconazole for better management of oral candidiasis. The NLCs were fabricated using an emulsification/sonication technique. The nanoparticles consisted of stearic acid, oleic acid, Pluronic F127, and lecithin. Box-Behnken design, artificial neural networking, and variable weight desirability were employed to optimize the joint effect of drug concentration in the drug/lipid mixture, solid lipid concentration in the solid/liquid lipid mixture, and surfactant concentration in the total mixture on size and entrapment. The optimized NLCs were coated with chitosan. The nanoparticles were characterized by surface charge, spectroscopic, thermal, morphological, mucoadhesion, release, histopathological, and antifungal properties. The nanoparticles are characterized by a particle size of 335 ± 13.5 nm, entrapment efficiency of 73.1 ± 4.9%, sustained release, minor histopathological effects on rabbit oral mucosa, and higher fungal inhibition efficiency for an extended period of time compared with fluconazole solution. Coating the nanoparticles with chitosan increased its adhesion to rabbit oral buccal mucosa and improved its anti-candidiasis activity. It is concluded that mucoadhesive lipid-based nanoparticles amplify the effect of fluconazole on

Published
2021
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3. Enhanced full-thickness wound healing via Sophora gibbosa extract delivery based on a chitosan/gelatin dressing incorporating microemulsion

Author

Abd El Ghany A. Moustafa, Ameeduzzafar Zafar, Arafa Musa, Mohamed F. Ibrahim, Ehab M Mostafa, Mohammed Elmowafy, Khaled Shalaby, and Nabil K. Alruwaili

Subjects
Pharmacology, Sophora, food.ingredient, biology, fungi, Organic Chemistry, food and beverages, Pharmaceutical Science, biology.organism_classification, Gelatin, Synthetic drugs, Chitosan, chemistry.chemical_compound, food, chemistry, Drug Discovery, Full thickness, Microemulsion, Wound healing, Biomedical engineering
Abstract

There are many synthetic drugs in literature have been utilized in healing of the wounds although the natural product specially antioxidants can offer similar if not better biological activity in t...

Published
2021
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4. Enhanced full-thickness wound healing via

Author

Khaled, Shalaby, Ehab M, Mostafa, Arafa, Musa, Abd El Ghany A, Moustafa, Mohamed F, Ibrahim, Nabil K, Alruwaili, Ameeduzzafar, Zafar, and Mohammed, Elmowafy

Subjects
Chitosan, Wound Healing, Plant Extracts, Gelatin, Bandages, Sophora
Abstract

There are many synthetic drugs in literature have been utilized in healing of the wounds although the natural product specially antioxidants can offer similar if not better biological activity in that regard. Genus Sophora is well known to contain flavonoids and phenolic compounds which have antioxidant and inflammatory effects. So, the aim of the current study was to develop and evaluate chitosan/gelatin based

Published
2020

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