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1. pH and its applications in targeted drug delivery

Author

Abdella, Sadikalmahdi, primary, Abid, Fatima, additional, Youssef, Souha H., additional, Kim, Sangseo, additional, Afinjuomo, Franklin, additional, Malinga, Constance, additional, Song, Yunmei, additional, and Garg, Sanjay, additional

Published
2023
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2. pH and its applications in targeted drug delivery

Author

Sadikalmahdi Abdella, Fatima Abid, Souha H. Youssef, Sangseo Kim, Franklin Afinjuomo, Constance Malinga, Yunmei Song, Sanjay Garg, Abdella, Sadikalmahdi, Abid, Fatima, Youssef, Souha H, Kim, Sangseo, Afinjuomo, Franklin, Malinga, Constance, Song, Yunmei, and Garg, Sanjay

Subjects
Pharmacology, acidic, formulations, Drug Discovery, pH-sensitive, alkaline, targeted drug delivery, diseases
Abstract

Refereed/Peer-reviewed Physiologic pH is vital for the normal functioning of tissues and varies in different parts of the body. The varying pH of the body has been exploited to design pH-sensitive smart oral, transdermal and vaginal drug delivery systems (DDS). The DDS demonstrated promising results in hard-to-treat diseases such as cancer and Helicobacter pylori infection. In some cases, a change in pH of tissues or body fluids has also been employed as a useful diagnostic biomarker. This paper aims to comprehensively review the development and applications of pH-sensitive DDS as well as recent advances in the field.

Published
2023

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