1. Bioprinted three dimensional human tissues for toxicology and disease modeling
- Author
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Deborah G. Nguyen and Stephen L. Pentoney
- Subjects
0301 basic medicine ,Human toxicity ,High rate ,Bioprinting ,Disease ,Biology ,Kidney ,Toxicology ,Models, Biological ,In vitro ,03 medical and health sciences ,030104 developmental biology ,Liver ,In vivo ,Drug Discovery ,Printing, Three-Dimensional ,Molecular Medicine ,In vitro tissue culture ,Humans ,Skin - Abstract
The high rate of attrition among clinical-stage therapies, due largely to an inability to predict human toxicity and/or efficacy, underscores the need for in vitro models that better recapitulate in vivo human biology. In much the same way that additive manufacturing has revolutionized the production of solid objects, three-dimensional (3D) bioprinting is enabling the automated production of more architecturally and functionally accurate in vitro tissue culture models. Here, we provide an overview of the most commonly used bioprinting approaches and how they are being used to generate complex in vitro tissues for use in toxicology and disease modeling research.
- Published
- 2016