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A study conducted at King Saud University in Riyadh, Saudi Arabia, explores the integration of Artificial Intelligence (AI) and Natural Language Processing (NLP) in healthcare data analytics and decision-making processes. The research focuses on personalized medicine, disease diagnosis, treatment recommendations, and resource optimization in the Internet of Medical Things (IoMT). By combining advanced data analytics methodologies with NLP capabilities, the study demonstrates the potential of AI-NLP fusion in enhancing patient care, operational efficiency, and healthcare outcomes. The research emphasizes the transformative impact of AI-NLP fusion on the future of healthcare, showcasing improved diagnostic accuracy, patient-specific treatment plans, and early risk stratification. [Extracted from the article]

A study conducted at King Saud University in Riyadh, Saudi Arabia, focused on developing delafloxacin-loaded PLGA nanoparticles for potential ocular use in treating eye infections caused by bacteria. The nanoparticles were characterized for size, drug loading, release, and antimicrobial efficacy, showing promise for ocular applications. The research concluded that the nanoparticles exhibited stability over time and significant potential as a nanoformulation for ocular treatments. For more information, readers can refer to the original article in ACS Omega. [Extracted from the article]

A recent study conducted at King Saud University in Riyadh, Saudi Arabia, explored the formation of metal-based complexes of the antibiotic drug succinylsulfathiazole with lanthanide metal ions La(III), Sm(III), and Tb(III). The research involved spectral characterizations, microscopic imaging, and thermal properties analysis of these complexes. The study found that the complexes exhibited different surface topography, as revealed by microscopic pictures. This research provides valuable insights into the interactions between antibiotics and metal ions, contributing to the field of drug development and therapeutics. [Extracted from the article]

Researchers from King Saud University conducted a study on the use of surface-engineered niosomes of Esculin hydrate for managing depression through intranasal administration. The study optimized the formulation using Design Expert software and found that the chitosan-coated niosomes exhibited sustained drug release and increased drug permeation compared to the pure drug suspension. The research highlighted the potential of this approach for enhancing the therapeutic efficacy of Esculin hydrate in depression management, calling for further clinical investigations. The study was published in the Journal of Drug Delivery Science and Technology and received financial support from King Saud University. [Extracted from the article]

Researchers from King Faisal University in Riyadh, Saudi Arabia, have conducted a study on hypertension, focusing on various experimental animal models used in antihypertensive drug development. The research highlights the importance of animal models in studying the pathophysiology of hypertension and evaluating potential therapies, despite their limitations compared to human models. The study emphasizes the ethical considerations that researchers must adhere to when using animal models for experimentation. This peer-reviewed research provides valuable insights into the development of antihypertensive drugs and the role of animal models in this field. [Extracted from the article]

A recent study conducted at King Saud University in Riyadh, Saudi Arabia, explored the interaction of curcumin with N-cyclodextrin and its binding with DNA using various biophysical methods and molecular docking. The research found that curcumin interacts with both N-cyclodextrin and DNA, with a higher binding affinity for DNA. The study suggests a potential route for the transfer of encapsulated therapeutic payloads to DNA targets. This peer-reviewed research provides valuable insights into biophysical studies and drug-induced toxicity. [Extracted from the article]

Research from the College of Science in Riyadh, Saudi Arabia, explores the potential of using carbon nanotubes as a novel drug delivery system for treating neurodegenerative disorders. The study highlights the unique characteristics of carbon nanotubes that make them promising for overcoming the challenges of delivering drugs across the blood-brain barrier. By functionalizing carbon nanotubes and utilizing diverse chemical modification techniques, researchers aim to enhance their biocompatibility and effectiveness as drug carriers. This innovative approach shows promise for more efficient treatments for neurodegenerative disorders. [Extracted from the article]

Researchers at Princess Nourah Bint Abdulrahman University in Riyadh, Saudi Arabia, conducted a study on the therapeutic impact of bitter gourd seed-fortified crackers on diabetic rats. The study found that incorporating bitter gourd seeds into the diet of diabetic rats led to significant improvements in various biomarkers associated with diabetes. The researchers recommend regular dietary intake of bitter gourd or bitter gourd seeds to mitigate the negative health outcomes of diabetes and its related metabolic disorders. [Extracted from the article]

Researchers from King Saud University in Riyadh, Saudi Arabia, have conducted a study on the synthesis of nitrogen and sulfur-doped carbon dots (SCDs) for potential use in antioxidants and drug delivery. The SCDs were found to have a size of 4.2 nm and demonstrated antioxidant properties with over 80% radical scavenging capability. The research highlights the potential applications of SCDs in bioimaging, drug delivery, and as potent antioxidant agents. This study was supported by financial assistance from King Saud University and was published in RSC Advances. [Extracted from the article]

Researchers at Princess Nourah Bint Abdulrahman University in Riyadh, Saudi Arabia, conducted a study on the effectiveness of novel nanocomposite shielding materials in reducing out-of-field radiation doses during radiation therapy. The study utilized Geant4 Monte Carlo simulations with an anthropomorphic female phantom and focused on two radiation modalities: 6 MV beams with and without flattening filters. The research concluded that these nanocomposite materials could significantly lower radiation exposure to non-target tissues, potentially enhancing patient safety during external radiation therapy. [Extracted from the article]

Researchers at King Saud Bin Abdulaziz University for Health Sciences in Riyadh, Saudi Arabia, have developed a system upgrade to prevent unintentional overrides of severe drug allergy alerts in electronic healthcare systems. The upgrade includes an alternative interruption in the computerized physician order entry process that requires co-signature from another prescriber before proceeding with a drug-to-drug match and a documented severe drug allergy symptom. This proactive approach aims to enhance medication safety and prevent allergy-related harm, ultimately improving patient safety. The study provides a model for institutions looking to implement similar measures to enhance patient safety in electronic healthcare systems. [Extracted from the article]

A study conducted at Princess Nourah Bint Abdulrahman University in Riyadh, Saudi Arabia, focused on the antimicrobial effect of a new active oxygen fluid (Blue(R) m) as a root canal irrigant against Enterococcus faecalis compared to sodium hypochlorite (NaOCl). The research involved using extracted human teeth contaminated with Enterococcus faecalis and concluded that the active oxygen fluid showed promise as an effective root canal irrigant. The study was published in Oral Health & Preventive Dentistry and was financially supported by Princess Nourah bint Abdulrahman University. [Extracted from the article]

A recent report from King Saud University in Riyadh, Saudi Arabia, discusses the development of a miniaturized capillary electrophoresis system for the simultaneous analysis of the antidiabetic drug linagliptin and the antibiotic cefixime in clinical settings. The study successfully established the conditions for electrophoretic separation and analysis of the drugs, and the system was found to be sensitive and cost-effective. The research aims to support the pharmacokinetics and therapeutic monitoring of the combination therapy in diabetic patients. This study provides valuable insights into the simultaneous determination of these drugs in clinical biological specimens. [Extracted from the article]

A recent report from King Saud University in Riyadh, Saudi Arabia discusses the use of emulsion liquid membrane (ELM) as a technique to eliminate ranitidine (RAN) from aqueous media. Ranitidine is a commonly recommended medication for reducing stomach acid, but it is persistent in water and nonbiodegradable. The ELM system, which includes sulfuric acid, kerosene, Span 80, and D2EHPA, was found to effectively extract RAN from water. The study also investigated the permeation of RAN from various real water matrices. The research concludes that the ELM system provides an interesting advanced separation technique for removing RAN from water. [Extracted from the article]

A new report from researchers at King Saud University in Riyadh, Saudi Arabia, examines the equity and accessibility of urgent care services in primary healthcare centers (PHCs) across Riyadh. The study found significant regional disparities in urgent care accessibility, with residents in the Western region reporting the highest access and awareness. The research highlights the need for targeted interventions to enhance PHC capabilities and utilization, ensuring alignment with personalized healthcare principles that cater to specific regional needs and conditions. The study was conducted through a cross-sectional online survey with 359 participants from diverse Riyadh neighborhoods. [Extracted from the article]

A study conducted by researchers from the College of Science in Riyadh, Saudi Arabia, focused on the synthesis and characterization of Fe(III) complexes with thiosemicarbazide ligands. The structures of the complexes were determined to be octahedral, and their antibacterial activities were evaluated. The results showed that the Fe(III) complexes exhibited greater antibacterial effects compared to the free ligands, except for one complex which demonstrated lower activity. However, the Fe(III) complexes showed lower activity compared to their corresponding ligands in tested cell lines. The study also found that the ligands demonstrated higher cytotoxicity compared to a known anticancer drug. [Extracted from the article]

A recent report from Princess Nourah Bint Abdulrahman University in Riyadh, Saudi Arabia, explores the use of nanocages as drug delivery systems. The researchers used density functional theory (DFT) and time-dependent DFT simulations to investigate the potential of different metals on Be12O12 as carriers for nitrosourea (NUA) drugs. The study found that drugs on nanocages have the potential to adsorb with less energy gap and hardness than free drugs, which could facilitate electron transfer and signal activity at the target location. The research suggests that this work can be extended to study the effect of other types of nanorings and nanocages on drug delivery carrier properties. [Extracted from the article]

A study conducted in Riyadh, Saudi Arabia, has found that benzohydrazide derivatives have good biological activity against bacteria and different cancer cell lines. The study synthesized and characterized seven metal complexes of benzohydrazide derivatives, which showed respectable activity against bacteria and demonstrated higher cytotoxic activity against human liver cancer cells. The study also investigated the inhibitory activity of the benzohydrazide derivative and its complexes on quinone oxidoreductase 2, a protein associated with liver cancer. The results highlighted the potential of organometallic compounds in cancer chemotherapy. [Extracted from the article]

A study conducted by researchers at the College of Science in Riyadh, Saudi Arabia, explores the potential of sulforaphane, a compound found in cruciferous vegetables, as an anti-virulence and anti-quorum sensing agent against Pseudomonas aeruginosa. P. aeruginosa is a significant bacterium that can cause severe illness and antibiotic resistance. The study found that sulforaphane at sub-inhibitory concentrations reduced biofilm formation, motility, oxidative stress resistance, and the synthesis of virulence factors in P. aeruginosa. It also showed promise in reducing the severity of P. aeruginosa infection in mice and enhancing the effectiveness of anti-pseudomonal antibiotics. The research suggests further investigation into sulforaphane and similar compounds as potential anti-quorum sensing candidates. [Extracted from the article]

A recent study conducted at AlFaisal University in Riyadh, Saudi Arabia, explored the characteristics and pharmacological management of primary Sjogren's Syndrome (pSS) in Saudi patients. The study found that pSS can occur before the age of 40 among Saudi citizens and that elevated erythrocyte sedimentation rate (ESR) levels are a common feature of the disease. The study also observed differences in medication usage between early-onset and late-onset pSS, suggesting potential disease progression. However, further research is needed to confirm these findings. [Extracted from the article]

A recent study conducted at King Saud University in Riyadh, Saudi Arabia, has explored the formation and characterization of a charge transfer complex (CTC) between the drug Alectinib and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). The study found that the CTC was formed in methanol and exhibited specific properties, such as a maximum absorption peak at 505 nm and a band gap energy of 1.94 eV. The research also developed a novel microwell spectrophotometric method for quantifying Alectinib, which could be useful in quality control laboratories. This study provides valuable insights into the development of multikinase inhibitors and their potential applications in cancer treatment. [Extracted from the article]

A study conducted by researchers from the College of Science in Riyadh, Saudi Arabia, focuses on the synthesis and experimental structure of a multifunctional catechol-azomethinebenzoic acid. The researchers confirmed the structure of the acid derivative through various spectroscopic techniques and a single-crystal X-ray diffraction study. The study also involved DFT/dmol3 calculations and molecular docking with Hsp90. The researchers found that the acid derivative showed promising drug-likeness properties and could potentially be a suitable inhibitor. The research has been peer-reviewed and published in ChemistrySelect. [Extracted from the article]

A study conducted at Princess Nourah Bint Abdulrahman University in Riyadh, Saudi Arabia aimed to evaluate the prevalence of urinary tract infections (UTIs) in pregnant women and determine the antimicrobial resistance patterns of bacterial pathogens isolated from pregnant and nonpregnant women. The study found that the overall prevalence of UTIs in pregnant women was 5%, with 1% being symptomatic and 4% being asymptomatic. The most common bacteria found in both pregnant and nonpregnant women were Escherichia coli and Klebsiella pneumoniae. The study concluded that nitrofurantoin and amoxicillin-clavulanic acid are recommended as empirical therapy for UTIs in both pregnant and nonpregnant women due to the low resistance of bacteria to these drugs. [Extracted from the article]

Researchers at Princess Nourah Bint Abdulrahman University in Riyadh, Saudi Arabia have conducted a study on the interaction between the drug amiloride and nanocages. Amiloride is used in the treatment of hypertension and heart failure. The study used density functional theory to analyze the adsorption of amiloride on different surfaces of nanocages. The research found that the drug's adsorption energy varied depending on the surface, and the study suggests that further research can be done to investigate the effects of different nanorings and nanocages on drug delivery. [Extracted from the article]

A new report from Princess Nourah Bint Abdulrahman University in Riyadh, Saudi Arabia, analyzes the electrical and vibrational characteristics of disulfiram (DSM) with various metal clusters using the DFT method. The study finds that the complexes formed are surprisingly stable and have distinct energy gaps compared to pure metal clusters. The research also suggests that DSM and metal clusters can exchange charges, leading to enhanced Raman modes and the potential for DSM to be used as a work function-based sensor. The study concludes that DSM with metal clusters has a longer recovery period, indicating its potential for storage or removal from a specific environment. [Extracted from the article]

A recent study conducted at the College of Pharmacy in Riyadh, Saudi Arabia, investigated the potential therapeutic effects of Cichorium intybus L. (CI) on chronic unpredictable mild stress-induced depression in mice. The researchers found that oxidative stress, which is linked to free radical generation, contributes to depression. The study showed that CI, known for its antioxidant properties, reversed behavioral changes in mice subjected to chronic stress, increased antioxidant enzyme levels, decreased lipid peroxidation, and ultimately increased serotonin levels in the brain. These findings suggest that CI holds promise as a therapeutic agent for depression by strengthening the antioxidant defense system. [Extracted from the article]

A study conducted at Prince Sultan Military Medical City in Riyadh, Saudi Arabia, aimed to establish antibiogram data for patients with spinal cord injury (SCI) and urinary tract infections (UTIs). The study found that the most common organism causing UTIs in SCI patients was Escherichia coli, which was more frequent in patients using self-intermittent catheterization as the voiding method. Proteus mirabilis was more common in patients using suprapubic catheters, and Klebsiella pneumoniae was more common in patients voiding freely. The study also found that nitrofurantoin was the most overall sensitive oral antibiotic for treating UTIs in SCI patients. [Extracted from the article]

A research report from Princess Nourah Bint Abdulrahman University in Riyadh, Saudi Arabia discusses the investigation of the adsorption and sensor properties of resorcinol (RSL) on X9N9 (X = Al, B, Ga, In) nanorings using density functional theory. The study found that RSL had a strong interaction with all the nanorings, causing a charge transfer and inducing a dipole moment. The research suggests that these nanorings could be used as electronic sensors and work function-based sensors for RSL, and could potentially be used for drug delivery. The study also mentions the possibility of investigating the effect of coinage metal doping with nanorings. [Extracted from the article]

A study conducted at Princess Nourah Bint Abdulrahman University in Riyadh, Saudi Arabia, focused on the formulation and evaluation of a multicomponent inclusion complex of Cyclosporine A (CP). The researchers prepared the inclusion complex using cyclodextrin and cyclodextrin with TPGS. The study found that the prepared inclusion complexes showed a significant enhancement in solubility and dissolution, indicating that they could be an alternative to conventional delivery systems for enhancing the solubility of highly lipophilic drugs. The research was published in the Journal of Inclusion Phenomena and Macrocyclic Chemistry and was supported by Princess Nourah Bint Abdulrahman University. [Extracted from the article]

A study conducted in Riyadh, Saudi Arabia, examined the visual response of methanol-induced optic neuropathy to treatment with erythropoietin (EPO) in addition to conventional therapy. The study included nine patients, with eight being male and one female, with a mean age of 37.7 years. The results showed that there was no significant difference in visual outcome between patients who received EPO and those who received only conventional management. The study concluded that managing visual impairments in individuals with methanol-induced optic neuropathy using EPO resulted in similar final visual outcomes compared to conventional management. [Extracted from the article]

A study conducted in Riyadh, Saudi Arabia, focuses on the synthesis and characterization of a new material called (HFlucytosine)2BiCl5. The structure of the material was analyzed using single crystal X-ray diffraction, revealing one-dimensional il [BiCl5]n2- chains surrounded by the flucytosine antifungal drug. The compound's optical properties and band gap were also studied, and theoretical calculations were performed to support the experimental findings. The research aims to determine the efficacy of these compounds in inhibiting the proliferation of harmful bacteria through an agar disc diffusion assay. [Extracted from the article]

A study conducted by the College of Pharmacy in Riyadh, Saudi Arabia, explored the anxiolytic effects of Manilkara zapota (MZ) leaf extract on caffeine-induced anxiety in mice. The study found that MZ leaf extract demonstrated a significant increase in behavioral activity and improved antioxidant status, leading to restored serotonin levels and prevention of structural damage in the brain. The researchers concluded that further research could provide a cost-effective alternative source for treating anxiety disorders. This research has been peer-reviewed and published in the Journal of Biological Regulators and Homeostatic Agents. [Extracted from the article]

Researchers from Princess Nourah Bint Abdulrahman University in Riyadh, Saudi Arabia have conducted a study on the radiation interaction properties of antibiotics and their implications for stability, efficacy, and structural integrity. Using advanced MCNPX Monte Carlo simulation, the researchers observed varied interaction patterns among different antibiotics and found significant findings on their photon interaction characteristics. The study highlights the potential molecular changes in antibiotics due to radiation exposure and emphasizes the importance of evaluating drugs in radiation-rich environments to ensure their effectiveness and safety. The research has been peer-reviewed and published in Radiation Physics and Chemistry. [Extracted from the article]

A report from the College of Medicine in Riyadh, Saudi Arabia discusses the prevalence, risk factors, antimicrobial sensitivity, and resistance mechanisms of Acinetobacter baumannii (A. baumannii) in Saudi Arabia. The research highlights that A. baumannii is a significant opportunistic pathogen that has developed resistance to various antimicrobials, including carbapenems. The high prevalence of hospital-acquired infections caused by A. baumannii in Saudi Arabia is attributed to factors such as the high number of critically ill patients, gastrointestinal colonization, and the widespread use of antimicrobial medications. The study suggests that combinations of colistin and tigecycline with carbapenems or other antibiotics are the best treatment option for multidrug-resistant A. baumannii infections. The researchers emphasize the need for further research into the molecular mechanisms of multidrug resistance and the establishment of treatment protocols to reduce the infection burden in Saudi Arabia. [Extracted from the article]

Researchers at Princess Nourah Bint Abdulrahman University in Riyadh, Saudi Arabia, have conducted a study on the adsorption of the drug toremifene on different compounds using simulations and analyses. The study found that the most stable complexes were formed with carboxylic acid-functionalized coronene doped with boron/nitrogen. The presence of these compounds increased the interaction between the drug and the molecules. The research provides insights into the chemical properties and interactions of toremifene, which could contribute to the development of more effective therapies. [Extracted from the article]

A recent study conducted at King Saud University in Riyadh, Saudi Arabia, explored the outcomes of the endoscopic endonasal approach (EEA) for the treatment of clival chordomas, a type of low-grade malignant tumor. The study included 17 patients who underwent EEA and found that the majority of patients underwent postoperative radiotherapy without severe toxicities. The 2-year overall survival rate was 82.4%, and the progression-free survival rate was 76.5%. The study suggests that EEA followed by CyberKnife radiosurgery could be a viable alternative to proton beam therapy for the treatment of clival chordomas. Further research is needed to directly compare these treatment modalities. [Extracted from the article]

A study conducted at King Saud University in Riyadh, Saudi Arabia, focused on optimizing the extraction process of sinapic acid from Fragaria ananassa using ultrasonic assisted extraction (UAE). The study found that the most favorable conditions for extraction were a temperature of 60 degrees C, an extraction time of 55 minutes, and a liquid-to-solid ratio of 30 mL/g. The UAE method proved to be highly effective, reducing extraction time and producing higher levels of sinapic acid compared to traditional techniques. The study concluded that this optimized method, combined with HPLC-UV analysis, could be valuable for efficiently extracting and estimating sinapic acid from Fragaria ananassa, benefiting industrial applications requiring high extraction yields of these organic molecules. [Extracted from the article]

A recent study conducted at King Saud University in Riyadh, Saudi Arabia, explored the protective effects of liposomal resveratrol against kidney injury induced by isoproterenol (ISO). ISO is a medication used to treat bradycardia and cardiogenic shock but can cause damage to the heart and kidneys. The researchers found that liposomal resveratrol significantly ameliorated kidney damage in rats by downregulating MAPK, cystatin c, Fas, and lipocalin-2. This study suggests that liposomal resveratrol could be a promising approach for preventing ISO-induced kidney injury. [Extracted from the article]

Researchers from King Saud University in Riyadh, Saudi Arabia have developed computational intelligence models to estimate the solubility and bioavailability of orally-taken drugs in supercritical fluid (SCF), specifically carbon dioxide (CO2). The study utilized machine learning models, including K-Nearest Neighbor (KNN), Multilayer Perceptron (MLP), and Support Vector Regression (SVR), to predict the solubility of Capecitabine in CO2SCF. The MLP model demonstrated the best performance, with a coefficient of determination of 0.996 and an error rate of 1.54. This research has implications for the development of sustainable and environmentally-friendly drug delivery technology. [Extracted from the article]

A report from the King Faisal Specialist Hospital and Research Center in Riyadh, Saudi Arabia, discusses the management of Helicobacter pylori infection in Saudi Arabia. The report highlights the increasing prevalence of antibiotic-resistant bacteria globally, including in Saudi Arabia, and the lack of consensus on the management of H. pylori in the country. The Saudi Gastroenterology Association developed practice guidelines to provide recommendations for healthcare providers. The report suggests that standard triple therapy is no longer recommended due to high rates of antibiotic resistance, and bismuth quadruple therapy is considered the best first-line and second-line therapy. The working group also recommends further studies to explore more therapeutic options for eradicating H. pylori. [Extracted from the article]

A recent study conducted at the King Faisal Specialist Hospital and Research Centre in Riyadh, Saudi Arabia, has found that germline succinate dehydrogenase subunit B (SDHB) pathogenic variants can cause aggressive and resistant pituitary adenomas (PAs) in the absence of paraganglioma or pheochromocytoma. The researchers describe the case of a 38-year-old woman with a giant pituitary macroprolactinoma that was resistant to traditional treatments but responded well to temozolomide. Genetic testing confirmed that she carried a pathogenic SDHB mutation. This study suggests that SDHB mutations should be considered as a possible cause of treatment resistance and aggressiveness in similar cases. [Extracted from the article]

A recent study conducted at King Saud University in Riyadh, Saudi Arabia, has found that the marine heterotrophic dinoflagellate Crypthecodinium AL-05 can be successfully grown using macroalgal hydrolysate as a low-cost carbon source. This strain of Crypthecodinium is known for its ability to accumulate lipids, including docosahexaenoic acid, which has pharmaceutical and nutraceutical applications. The research showed that glucose at a concentration of 40 g/l produced the best results, followed by macroalgae alone or with glucose or molasses. The study also found that Crypthecodinium AL-05 grown on macroalgae produced only saturated fatty acids, with caprylic acid representing 43.45% of the total fatty acids. This research has implications for the commercial production of caprylic acid using macroalgae as a carbon source. [Extracted from the article]

A recent study conducted by researchers at Princess Nourah Bint Abdulrahman University in Riyadh, Saudi Arabia, focused on the antimicrobial resistance (AMR) of uropathogenic bacteria, specifically Escherichia coli. The study analyzed urine samples from hemodialysis patients with urinary tract infections (UTIs) and found that Escherichia coli was the most prevalent bacteria, followed by Citrobacter freundii, Morganella morganii, Enterobacter aerogenes, and Pseudomonas aeruginosa. The genetic analysis revealed that the bla-CTXM gene was the most prevalent, followed by bla-SHV and bla-VIM. The study concluded that antibiotics such as Tigecycline, Meropenem, Fosfomycin, Nitrofurantoin, and Amikacin may be effective treatment options against multidrug-resistant uropathogenic bacteria. [Extracted from the article]

A study conducted by researchers at AlFaisal University in Riyadh, Saudi Arabia, examined the quality attributes of five different brands of atorvastatin calcium tablets available in the Saudi Arabian market. The tablets were tested for conformity with United States Pharmacopoeia (USP) specifications, including weight variation, hardness, friability, disintegration time, and dissolution rate. The study found that all of the tested tablets met USP specifications and passed local validation, with only minor variations in critical quality attributes detected for two brands. The research suggests the presence of some differences in tablet manufacturing processes. [Extracted from the article]

Researchers at Princess Nourah Bint Abdulrahman University in Riyadh, Saudi Arabia have conducted a study on carboplatin therapy. The objective of the study was to prepare carboplatin loaded cubosomes using a high shear homogenization technique. The researchers found that the selected composition of the formulation was suitable for preparing nanosized cubosomes with suitable entrapment efficiency of the drug. The study provides insights into the formulation and evaluation of pluronic F-127 assisted carboplatin cubosomes. [Extracted from the article]

A new report from the College of Applied Medical Science in Riyadh, Saudi Arabia discusses the use of Internet of Things (IoT) technology and big data frameworks in a student health monitoring system. The researchers propose an IoT-based system that utilizes a MapReduce framework and deep learning architecture to identify the health status of students. The system collects and normalizes data from IoT devices, extracts deep features using Autoencoder and 1-dimension Convolution Neural Network (1DCNN), performs optimal feature selection with Adaptive Bird Rat Swarm Optimization (ABRSO), and classifies the student's health status using Weight Optimized Recurrent Neural Network (WO-RNN) with Ridge classifier. The research concludes that the proposed system shows improved performance. [Extracted from the article]

A recent study conducted at King Saud University in Riyadh, Saudi Arabia, explored the synthesis and anticancer activity of heterocycles containing 1,2,3-triazole and pyrazole moieties. These heterocycles are important components of various compounds, including pharmaceuticals. The researchers synthesized different heterocycles and assessed their activity against human cancer cells and a healthy cell line. One particular heterocycle, thiocarbohydrazone, showed the most promising cytotoxic activity, comparable to the reference drug doxorubicin. The other heterocycles exhibited moderate cytotoxic activities. This research has been peer-reviewed and provides valuable insights into potential anticancer agents. [Extracted from the article]

A recent study conducted by researchers at the College of Pharmacy in Riyadh, Saudi Arabia, explored the potential of metformin-loaded coconut oil nanoemulsion as an anticancer medication. The researchers characterized the nanoemulsion and evaluated its effects on MCF-7, HepG2, and HCT-116 cell lines. The results showed that the metformin-loaded coconut nanoemulsion exhibited significantly improved anticancer activities compared to non-formulated metformin. The study suggests that this formula could be a promising new option for cancer therapy. [Extracted from the article]

A recent study conducted by researchers at Imam Mohammad Ibn Saud Islamic University in Riyadh, Saudi Arabia, explored the chemical profile and potential therapeutic effects of essential oils from Pulicaria arabica on lung cancer cells. The essential oils were found to have a moderate anti-proliferative effect on A549 lung cancer cells by inducing apoptosis and modulating cell cycle progression. The study suggests that Pulicaria arabica essential oils could be used as a potential therapeutic option for lung cancer treatment. Further research is needed to fully understand the mechanisms and potential benefits of these essential oils. [Extracted from the article]

Researchers from King Saud bin Abdulaziz University for Health Sciences in Riyadh, Saudi Arabia, have conducted a study on personalized medicine and its potential to address global health challenges. They highlight the importance of collaboration among countries to achieve Sustainable Development Goals and secure global health. The researchers emphasize the role of artificial intelligence (AI) in addressing these challenges, as AI has the ability to analyze health-related data and develop computational models and algorithms. However, ethical and legal concerns regarding privacy and autonomy must be addressed for effective implementation. The study concludes that personalized medicine and AI have the potential to strengthen global health and improve preparedness for future challenges. [Extracted from the article]