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The article discusses new findings on Adenoid Cystic Carcinoma (ACC) of the larynx, a rare malignant tumor that accounts for less than 1% of laryngeal malignancies. The research highlights two cases, one involving a 42-year-old woman and the other a 32-year-old man, both of whom underwent total laryngectomy with neck dissection and adjuvant radiotherapy. The study emphasizes the importance of long-term follow-up to assess the benefit and survival outcomes for patients with ACC. [Extracted from the article]

A recent study conducted at the King Hussein Cancer Center in Amman, Jordan, focused on personalized treatment strategies for breast adenoid cystic carcinoma (BACC), a rare subtype of breast cancer. The study analyzed data from 1212 patients using Machine Learning algorithms to predict 5-year survival rates and identified key prognostic indicators such as age, lymph node metastasis, and estrogen receptor status. The research concluded that while postoperative radiotherapy improved survival rates, the benefits of adjuvant chemotherapy were uncertain, emphasizing the importance of personalized treatment decisions. The study also introduced a web-based tool to aid in treatment optimization and prognostication. [Extracted from the article]

Researchers at Oslo University Hospital conducted a study on adenoid cystic carcinoma, comparing outcomes of patients treated with carbon-ion radiotherapy and photon radiotherapy. The study found that patients treated with carbon-ion radiotherapy had a higher incidence of osteoradionecrosis and worse prognosis compared to those treated with photon radiotherapy. The research highlights the importance of close follow-up and collaboration between treating centers to manage toxicity and improve quality of life for patients with adenoid cystic carcinoma. [Extracted from the article]

Researchers from Peking University in Beijing, China, have conducted a study on Adenoid Cystic Carcinoma (SACC), a malignant tumor that often metastasizes to the lungs. They found that inhibiting Cdh11 activates the cGAS-STING pathway by stimulating branched chain amino acid catabolism, which can help mitigate lung metastasis of SACC. The study suggests that targeting hybrid EMT cells, specifically through the use of celecoxib and its derivatives as CDH11 inhibitors, could be a promising treatment strategy for patients with SACC. This research was supported by the National Natural Science Foundation of China and the Natural Science Foundation of Beijing Municipality. [Extracted from the article]

A study conducted at the University of Brescia focused on developing a model to predict Relapse-Free Survival (RFS) in patients with Adenoid Cystic Carcinoma (AdCC) of the head and neck. The study utilized a combination of clinical and radiomic features from preoperative MRI scans to create a predictive model. The results showed that the combined clinical-radiomic model had the highest predictive accuracy and outperformed models based solely on clinical or radiomic features. This model could potentially assist clinicians in patient management and personalized treatment planning for AdCC patients. [Extracted from the article]

A recent study from Saveetha University in Tamil Nadu, India, focused on adenoid cystic carcinoma (ACC), a challenging cancer due to its slow growth and resistance to traditional treatments. The research highlighted the potential of targeting the AXL receptor to inhibit tumor growth and improve patient outcomes. The study concluded that further research into AXL biology and therapeutic strategies could reshape the treatment landscape for metastatic ACC. This information may be valuable for individuals interested in precision-based treatments for this type of cancer. [Extracted from the article]

A recent study conducted at Dr. D.Y. Patil Vidyapeeth in Maharashtra, India, focused on adenoid cystic carcinoma (ACC), a rare tumor that accounts for less than 1% of head and neck malignancies. The research highlighted the characteristics of sinonasal adenoid cystic carcinoma (SNACC), emphasizing its slow growth and potential for intracranial extension, necessitating surgical and radiotherapy treatment. The study underscored the importance of histological subtype and treatment options in determining the prognosis of SNACC, presenting rare histopathological findings in a case report. For more information, readers can access the full article in the Medical Journal of Dr. D.Y. Patil Vidyapeeth. [Extracted from the article]

A study conducted at Peking University in Beijing, China, focused on understanding bone metastasis in Adenoid Cystic Carcinoma (AdCC) through the dysregulation of the Notch signaling pathway and the potential therapeutic target SPARC. The research, which included 144 AdCC patients, found that SPARC may serve as a prognostic biomarker and therapeutic target for AdCC. The study highlighted the role of Notch activation in promoting bone metastasis by inhibiting SPARC expression in AdCC. [Extracted from the article]

The University of Saint Joseph conducted research on adenoid cystic carcinoma of the lacrimal gland, focusing on its clinical features, genetic factors, and treatment options. Adenoid cystic carcinoma is the most common malignant epithelial tumor of the lacrimal gland, presenting symptoms such as pain, eye swelling, double vision, and eye bulging. Early detection and appropriate treatment are crucial due to the tumor's aggressive nature, with surgical procedures and neoadjuvant intra-arterial chemotherapy being primary treatment options. The research emphasizes the importance of identifying prognostic factors to enhance treatment outcomes for patients with adenoid cystic carcinoma. [Extracted from the article]

A recent study conducted by Weill Cornell Medicine researchers analyzed data from the Surveillance, Epidemiology, and End Results (SEER) database to investigate the long-term survival outcomes of patients with adenoid cystic carcinoma (ACC) in different geographic regions of the United States. The study included 5150 patients and found that the West region exhibited the worst survival compared to the Northeast region. Factors such as age, sex, cancer type, disease stage, treatment modalities, social support, and geographic location were identified as independent predictors of late mortality in ACC patients. Further research is needed to explore the causal relationships between these factors. [Extracted from the article]

A study conducted by researchers at Van Yuzuncu Yil University Faculty of Medicine in Turkey explored the relationship between adenoid hypertrophy and childhood afebrile seizures. The researchers measured adenoid tissue volume and nasopharyngeal distance in children aged 2-8 years who presented with afebrile seizures. They found that increased adenoid tissue volume was significantly associated with a higher number of afebrile seizure episodes. This research suggests that volumetric adenoid tissue size may be a contributing factor to recurrent episodes of childhood afebrile seizure. [Extracted from the article]

A recent study conducted by researchers at the University of North Carolina Chapel Hill has examined the molecular characteristics of adenoid cystic carcinoma (AdCC), a slow-growing salivary gland malignancy. The study found that AdCCs of different anatomic subsites, such as the parotid, submandibular, sublingual, and minor salivary glands, exhibit differences in gene expression and tumor immune microenvironment composition. The study also identified variations in key tumorigenic pathways and immune cell populations between different subsites, suggesting that these differences may influence the overall survival of patients. The findings provide valuable insights into the understanding and treatment of AdCC. [Extracted from the article]

A recent study conducted by researchers at Seth GSMC and KEM Hospital focused on adenoid cystic carcinoma, a rare type of lung cancer. The study found that salivary gland-type lung carcinomas, including adenoid cystic carcinoma, are uncommon and represent less than 1% of all lung tumors. The researchers reported a case of a 38-year-old non-smoking man of North Indian origin who presented with symptoms of shortness of breath, cough, and weight loss. Despite palliative treatment, the patient passed away within two months of diagnosis. The study highlights the importance of imaging in determining the management plan for this type of cancer. [Extracted from the article]

A recent study conducted by Sungkyunkwan University School of Medicine in Seoul, South Korea, aimed to evaluate the effectiveness of dose-escalated radiotherapy (RT) for primary tracheobronchial adenoid cystic carcinoma (ACC), a rare form of cancer. The study retrospectively reviewed 48 patients who had undergone definitive or postoperative RT and found that dose-escalated RT with conventional fractionation may be effective, especially for a definitive aim. The study also identified regional lymph node metastasis at diagnosis and receipt of definitive RT as factors associated with poorer overall survival. The research provides valuable insights into the optimal RT dose for primary tracheobronchial ACC. [Extracted from the article]

A recent study conducted by researchers at NITTE (Deemed to be University) in Karnataka, India, has revealed new findings on adenoid cystic carcinoma, a rare and slow-growing tumor that develops from the mucous glands' epithelium. The study focused on a case of a 40-year-old male who presented with right-sided nasal obstruction, which was initially diagnosed as a mucocele. However, further examination and histopathology confirmed the presence of adenoid cystic carcinoma. The patient underwent endoscopic excision of the mass, followed by right orbital floor-sparing total maxillectomy and adjuvant radiotherapy. This research provides valuable insights into the diagnosis and treatment of this rare form of cancer. [Extracted from the article]

A recent report from Wayne State University provides new data on adenoid cystic carcinoma (ACC), an uncommon salivary gland cancer. The study found that ACC can be divided into two subtypes, ACC-I and ACC-II, with ACC-I being more aggressive and ACC-II having a more indolent phenotype. The research also explored the tumor immune microenvironment and found differences in immunologic profiles between the subtypes. Overall, the study concluded that ACC-I patients have worse outcomes regardless of treatment type. [Extracted from the article]

A recent study conducted by researchers at the University of Tennessee analyzed the behavior and treatment of adenoid cystic carcinoma (AdCC) in children and young adults. The study examined salivary gland malignancies in patients aged 0-21 with AdCC histology using the National Cancer Database from 2004 to 2018. The findings revealed that AdCC in children and young adults has an overall good prognosis, despite frequent high grade. The study suggests that cervical lymph node dissection may be important, but the value of systematic adjuvant therapy is not confirmed. These findings highlight the importance of population-based studies in shaping clinical practice and informing future investigations. [Extracted from the article]

A recent study conducted by Sungkyunkwan University School of Medicine in Seoul, South Korea, aimed to analyze the treatment patterns and outcomes for adenoid cystic carcinoma (ACC) in the nasal cavity and paranasal sinus. The study found that patients with extensive disease who underwent definitive radiation therapy (D(C)RT) generally had inferior clinical outcomes compared to those with less extensive disease who underwent surgery followed by postoperative radiation therapy (S+PORT). However, the significance of certain factors, such as T4b disease and neurologic symptoms, disappeared in the multivariate analysis. Overall, the study provides valuable insights into the treatment modalities and clinical outcomes of ACC. [Extracted from the article]

A recent study conducted by investigators at the University of Miami examined the expression of apoptotic markers in resected lacrimal gland adenoid cystic carcinoma (LGACC) tumor margins after neoadjuvant intra-arterial chemotherapy (IACC) and globe-sparing excision. The study found positive staining for multiple apoptotic markers at the tumor center and margin, suggesting the cytoreductive effects of IACC on LGACC. This research provides valuable insights into the cellular and molecular determinants of the cytoreductive effect of IACC on LGACC, which is a rare and lethal orbital malignancy. The study was supported by the Dr. Nasser Ibrahim Al-Rashid Orbital Vision Research Fund. [Extracted from the article]

A study conducted at Yale University examined the use of neoadjuvant intra-arterial cytoreductive chemotherapy (IACC) in the treatment of lacrimal gland adenoid cystic carcinoma (LGACC). The study found that patients treated with IACC had higher disease-specific survival rates compared to a population-based cohort treated with excision. However, further research is needed to validate these findings and to understand the impact of IACC on survival, late recurrence rates, and potential toxicities. The study provides insights into the long-term outcomes of patients treated with IACC and highlights the efficacy of this treatment strategy. [Extracted from the article]

A recent report from the Mayo Clinic in Rochester, Minnesota discusses the treatment outcomes of single-fraction stereotactic radiosurgery (SRS) for patients with adenoid cystic carcinoma. The study analyzed 55 patients with 66 lesions and categorized the SRS intentions as definitive, adjuvant, salvage, or palliative. The results showed that SRS provided a high rate of local tumor control, but marginal failure was frequent. Integrating SRS with added external beam radiation therapy (EBRT) showed potential for enhancing local and local/marginal tumor control, particularly in recurrent cases. [Extracted from the article]

A recent study conducted by researchers at Tianjin Medical University in China has explored new treatment options for salivary adenoid cystic carcinoma (SACC), a common type of salivary gland cancer. The current clinical therapies for SACC have limitations in preventing its development and metastasis. The researchers developed a nanomedicine called RCDT, which combines antivascular photodynamic therapy and neuroinhibitory chemotherapy to target and disrupt the tumor vasculature and inhibit neural spread. The study found that RCDT effectively suppressed the growth and metastasis of SACC. This research provides valuable insights into potential treatment options for SACC. [Extracted from the article]

A recent study conducted at the University of Texas MD Anderson Cancer Center in Houston, Texas, explored the expression of B7-H4 in different types of salivary gland carcinomas (SGC) and its potential as a prognostic marker and therapeutic target. The researchers found that B7-H4 expression was particularly high in adenoid cystic carcinoma (ACC) and was an independent prognostic marker for this disease. However, B7-H4 expression did not have prognostic relevance in other types of SGC. These findings have important implications for the development of targeted therapies for ACC. [Extracted from the article]

A recent study conducted by researchers at the University of California San Francisco (UCSF) has provided new insights into adenoid cystic carcinoma (AdCC), a rare form of triple-negative breast cancer. The study focused on the more aggressive solid-basaloid variant of AdCC (SB-AdCC) and found that it is characterized by solid growth, myxohyaline stroma, and immune-poor features. The researchers also identified genetic abnormalities in the Notch pathway and chromatin modifier genes in SB-AdCC. The study highlights the need for additional treatment approaches due to the aggressive behavior and poor treatment responses of SB-AdCC. [Extracted from the article]

A new report from researchers in Kanagawa, Japan discusses the use of carbon ion radiotherapy (CIRT) in the treatment of adenoid cystic carcinoma. The study focuses on a case of a 67-year-old woman who underwent salvage endoscopic laryngopharyngeal surgery after previous treatment with CIRT. The patient experienced delayed postoperative bleeding and necrosis of the tongue base, but ultimately preserved laryngeal function. The researchers emphasize the need for careful evaluation and observation when performing salvage transoral surgery in patients who have undergone CIRT. [Extracted from the article]

A recent report from Tokyo Medical University discusses the case of a 51-year-old man who was diagnosed with adenoid cystic carcinoma, a type of cancer, after experiencing discomfort in his pharynx. The man underwent tracheal segmental resection and radiation therapy, but developed anastomotic tracheal stenosis as a result. To address this, a silicon stent was placed to open the airway, and after one year, the stent was removed. The patient remains under follow-up and has been recurrence-free for 1.5 years. This case report provides valuable information on the temporary stenting technique for managing tracheal stenosis after tracheal resection of adenoid cystic carcinoma. [Extracted from the article]

Keywords: Adenoid Cystic Cancer; Adenoid Cystic Carcinoma; Adenoids; Cancer; Carcinomas; Diagnostics and Screening; Health and Medicine; Hemic and Immune Systems; Immunology; Lymphoid Tissue; Oncology EN Adenoid Cystic Cancer Adenoid Cystic Carcinoma Adenoids Cancer Carcinomas Diagnostics and Screening Health and Medicine Hemic and Immune Systems Immunology Lymphoid Tissue Oncology 1526 1526 1 10/09/23 20231013 NES 231013 2023 OCT 9 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- New study results on adenoid cystic carcinoma have been published. Adenoid Cystic Cancer, Adenoids, Adenoid Cystic Carcinoma, Cancer, Carcinomas, Diagnostics and Screening, Health and Medicine, Hemic and Immune Systems, Immunology, Lymphoid Tissue, Oncology. [Extracted from the article]

Keywords: Adenoid Cystic Cancer; Adenoid Cystic Carcinoma; Adenoids; Cancer; Carcinomas; Health and Medicine; Hemic and Immune Systems; Immunology; Lymphoid Tissue; Oncology; Peptides and Proteins; Proteins; Proteome EN Adenoid Cystic Cancer Adenoid Cystic Carcinoma Adenoids Cancer Carcinomas Health and Medicine Hemic and Immune Systems Immunology Lymphoid Tissue Oncology Peptides and Proteins Proteins Proteome 540 540 1 10/09/23 20231013 NES 231013 2023 OCT 9 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on adenoid cystic carcinoma. For more information on this research see: Analysis of proteome and post-translational modifications of 2-hydroxyisobutyrylation reveals the glycolysis pathway in oral adenoid cystic carcinoma. [Extracted from the article]

Adenoid Cystic Cancer, Adenoid Cystic Carcinoma, Adenoids, Cancer, Carcinomas, Health and Medicine, Hemic and Immune Systems, Immunology, Lymphoid Tissue, Oncology, Pediatrics Keywords: Adenoid Cystic Cancer; Adenoid Cystic Carcinoma; Adenoids; Cancer; Carcinomas; Health and Medicine; Hemic and Immune Systems; Immunology; Lymphoid Tissue; Oncology; Pediatrics EN Adenoid Cystic Cancer Adenoid Cystic Carcinoma Adenoids Cancer Carcinomas Health and Medicine Hemic and Immune Systems Immunology Lymphoid Tissue Oncology Pediatrics 1279 1279 1 07/10/23 20230714 NES 230714 2023 JUL 10 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on adenoid cystic carcinoma. [Extracted from the article]

Adenoid Cystic Cancer, Adenoids, Cancer, Carcinomas, Drugs and Therapies, Genetics, Health and Medicine, Hemic and Immune Systems, Immunology, Lymphoid Tissue, Oncology, Pharmaceuticals, Adenoid Cystic Carcinoma Keywords: Adenoid Cystic Cancer; Adenoid Cystic Carcinoma; Adenoids; Cancer; Carcinomas; Drugs and Therapies; Genetics; Health and Medicine; Hemic and Immune Systems; Immunology; Lymphoid Tissue; Oncology; Pharmaceuticals EN Adenoid Cystic Cancer Adenoid Cystic Carcinoma Adenoids Cancer Carcinomas Drugs and Therapies Genetics Health and Medicine Hemic and Immune Systems Immunology Lymphoid Tissue Oncology Pharmaceuticals 1423 1423 1 07/03/23 20230707 NES 230707 2023 JUL 3 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Data detailed on adenoid cystic carcinoma have been presented. According to the news reporters, the research concluded: "The results of the pathway analysis identified the upregulation of PI3K-Akt signaling, IL-17 signaling, and multiple other cancer pathways. [Extracted from the article]

Keywords: New York City; State:New York; United States; North and Central America; Adenoid Cystic Cancer; Adenoid Cystic Carcinoma; Adenoids; Cancer; Carcinomas; Cytoplasmic and Nuclear Receptors; DNA-Binding Proteins; Drugs and Therapies; Health and Medicine; Hemic and Immune Systems; Immunology; Lymphoid Tissue; Oncology; Proteins; Retinoic Acid; Retinoic Acid Receptors; Retinoid X Receptors; Therapy; Transcription Factors EN New York City State:New York United States North and Central America Adenoid Cystic Cancer Adenoid Cystic Carcinoma Adenoids Cancer Carcinomas Cytoplasmic and Nuclear Receptors DNA-Binding Proteins Drugs and Therapies Health and Medicine Hemic and Immune Systems Immunology Lymphoid Tissue Oncology Proteins Retinoic Acid Retinoic Acid Receptors Retinoid X Receptors Therapy Transcription Factors 1060 1060 1 06/26/23 20230627 NES 230627 2023 JUN 27 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- New research on Oncology - Adenoid Cystic Carcinoma is the subject of a report. Agonists of retinoic acid receptor (RAR) or retinoid X receptor (RXR) signaling (all-trans retinoic acid, bexarotene) promoted myoepithelial-to-ductal differentiation, whereas suppression of RAR/RXR signaling with a dominant-negative RAR construct abrogated it. Keywords for this news article include: New York City, New York, United States, North and Central America, Adenoid Cystic Cancer, Adenoid Cystic Carcinoma, Adenoids, Cancer, Carcinomas, Cytoplasmic and Nuclear Receptors, DNA-Binding Proteins, Drugs and Therapies, Health and Medicine, Hemic and Immune Systems, Immunology, Lymphoid Tissue, Oncology, Proteins, Retinoic Acid, Retinoic Acid Receptors, Retinoid X Receptors, Therapy, Transcription Factors, Columbia University Medical Center. [Extracted from the article]

Adenoid Cystic Carcinoma, Adenoids, Bone Research, Cancer, Carcinomas, Health and Medicine, Hemic and Immune Systems, Immunology, Lymphoid Tissue, Oncology, Adenoid Cystic Cancer Keywords: Adenoid Cystic Cancer; Adenoid Cystic Carcinoma; Adenoids; Bone Research; Cancer; Carcinomas; Health and Medicine; Hemic and Immune Systems; Immunology; Lymphoid Tissue; Oncology EN Adenoid Cystic Cancer Adenoid Cystic Carcinoma Adenoids Bone Research Cancer Carcinomas Health and Medicine Hemic and Immune Systems Immunology Lymphoid Tissue Oncology 1710 1710 1 06/12/23 20230616 NES 230616 2023 JUN 12 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Data detailed on adenoid cystic carcinoma have been presented. [Extracted from the article]

Keywords: Adenoid Cystic Cancer; Adenoid Cystic Carcinoma; Adenoids; Cancer; Cancer Therapy; Carcinomas; Drugs and Therapies; Health and Medicine; Hemic and Immune Systems; Immunology; Lymphoid Tissue; Oncology EN Adenoid Cystic Cancer Adenoid Cystic Carcinoma Adenoids Cancer Cancer Therapy Carcinomas Drugs and Therapies Health and Medicine Hemic and Immune Systems Immunology Lymphoid Tissue Oncology 1047 1047 1 05/02/23 20230505 NES 230505 2023 MAY 2 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- New study results on adenoid cystic carcinoma have been published. Adenoid Cystic Cancer, Adenoids, Cancer, Cancer Therapy, Carcinomas, Drugs and Therapies, Health and Medicine, Hemic and Immune Systems, Immunology, Lymphoid Tissue, Oncology, Adenoid Cystic Carcinoma. [Extracted from the article]

Keywords: Adenoid Cystic Cancer; Adenoid Cystic Carcinoma; Adenoids; Cancer; Carcinomas; Drugs and Therapies; Health and Medicine; Hemic and Immune Systems; Immunology; Lymphoid Tissue; Oncology; Radiotherapy EN Adenoid Cystic Cancer Adenoid Cystic Carcinoma Adenoids Cancer Carcinomas Drugs and Therapies Health and Medicine Hemic and Immune Systems Immunology Lymphoid Tissue Oncology Radiotherapy 1068 1068 1 03/27/23 20230331 NES 230331 2023 MAR 27 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators discuss new findings in adenoid cystic carcinoma. For more information on this research see: Radiotherapy for primary thyroid adenoid cystic carcinoma. [Extracted from the article]

Keywords: Adenoid Cystic Cancer; Adenoid Cystic Carcinoma; Adenoids; Cancer; Carcinomas; Health and Medicine; Hemic and Immune Systems; Immunology; Lymphoid Tissue; Oncology; Risk and Prevention; Therapy EN Adenoid Cystic Cancer Adenoid Cystic Carcinoma Adenoids Cancer Carcinomas Health and Medicine Hemic and Immune Systems Immunology Lymphoid Tissue Oncology Risk and Prevention Therapy 1471 1471 1 03/24/23 20230228 NES 230228 2023 FEB 27 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on adenoid cystic carcinoma. Adenoid Cystic Cancer, Adenoid Cystic Carcinoma, Adenoids, Cancer, Carcinomas, Health and Medicine, Hemic and Immune Systems, Immunology, Lymphoid Tissue, Oncology, Risk and Prevention, Therapy. [Extracted from the article]