Nicola Veronese, Cyrus Cooper, Olivier Bruyère, Nasser M. Al-Daghri, Jaime Branco, Etienne Cavalier, Sara Cheleschi, Mario Coelho da Silva Rosa, Philip G. Conaghan, Elaine M. Dennison, Maarten de Wit, Antonella Fioravanti, Nicholas R. Fuggle, Ida K. Haugen, Gabriel Herrero-Beaumont, Germain Honvo, Andrea Laslop, Radmila Matijevic, Alberto Migliore, Ali Mobasheri, Jean-Pierre Pelletier, María Concepción Prieto Yerro, Régis Pierre Radermecker, François Rannou, René Rizzoli, Jean-Yves Reginster, Repositório da Universidade de Lisboa, Veronese, Nicola, Cooper, Cyru, Bruyère, Olivier, Al-Daghri, Nasser M, Branco, Jaime, Cavalier, Etienne, Cheleschi, Sara, da Silva Rosa, Mario Coelho, Conaghan, Philip G, Dennison, Elaine M, de Wit, Maarten, Fioravanti, Antonella, Fuggle, Nicholas R, Haugen, Ida K, Herrero-Beaumont, Gabriel, Honvo, Germain, Laslop, Andrea, Matijevic, Radmila, Migliore, Alberto, Mobasheri, Ali, Pelletier, Jean-Pierre, Prieto Yerro, María Concepción, Radermecker, Régis Pierre, Rannou, Françoi, Rizzoli, René, and Reginster, Jean-Yves
© The Author(s) 2022 Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/., Knee osteoarthritis (OA) is one of the most common and disabling medical conditions. In the case of moderate to severe pain, a single intervention may not be sufficient to allay symptoms and improve quality of life. Examples include first-line, background therapy with symptomatic slow-acting drugs for OA (SYSADOAs) or non-steroidal anti-inflammatory drugs (NSAIDs). Therefore, the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) performed a review of a multimodal/multicomponent approach for knee OA therapy. This strategy is a particularly appropriate solution for the management of patients affected by knee OA, including those with pain and dysfunction reaching various thresholds at the different joints. The multimodal/multicomponent approach should be based, firstly, on different combinations of non-pharmacological and pharmacological interventions. Potential pharmacological combinations include SYSADOAs and NSAIDs, NSAIDs and weak opioids, and intra-articular treatments with SYSADOAs/NSAIDs. Based on the available evidence, most combined treatments provide benefit beyond single agents for the improvement of pain and other symptoms typical of knee OA, although further high-quality studies are required. In this work, we have therefore provided new, patient-centered perspectives for the management of knee OA, based on the concept that a multimodal, multicomponent, multidisciplinary approach, applied not only to non-pharmacological treatments but also to a combination of the currently available pharmacological options, will better meet the needs and expectations of patients with knee OA, who may present with various phenotypes and trajectories.