1. Elaborated DNA-binding specialities, in vitro medicated apoptosis and restrained malignancy of neotype water-soluble cationic porphyrin acylhydrazone Cu-complex.
- Author
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Feng, Xiaoxia, Wu, Yu, Zhang, Qian, and Liu, Jiacheng
- Subjects
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DNA-binding proteins , *APOPTOSIS , *PORPHYRINS , *COPPER compounds , *HYDROPHILIC compounds , *METAL complexes , *IN vitro studies - Abstract
Tetrad novel Cu-complex containing multifarious meso-10,15,20-Tris (N-methyl-2′-pyridyl)-5-(4′- X- acylhydrazone) porphyrin ligands, where X respectively referred to salicylaldehyde ( Cu-P1 ), o-Vanillin ( Cu-P2 ), pyridine-2-carboxaldehyde ( Cu-P3 ) and acetone ( Cu-P4 ), have been successfully isolated and well characterized. Multiple physicochemical approaches reveal the complex Cu-P4 with preferable binding affinity than its analogues due to smaller molecular dimension. Moreover, the mechanism of the anti-neoplasm action of these conjugates have been appraised via MTT assay, manifesting all of them possess superior cytotoxicity towards A549 (non-small cell lung cancer) and HepG2 (liver hepatocellular carcinoma cells) but weak cell toxicity for Hs 578Bst (human normal breast cells) which might be boiled down to porphyrin derivatives could enrich around malignant neoplasms. The flow cytometric analysis illustrates that delegate compound Cu-P4 induced cell death predominantly through late apoptosis and arrested S phase cells. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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