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Abstract Three water-soluble Cu(Ⅱ)-based acylhydrazone porphyrin derivatives (named as CuP1 , CuP2 and CuP3) were prepared and isolated successfully. Diversiform physicochemical approaches demonstrated that all of the complexes possess excellent binding affinity with ct-DNA, especially CuP3 exhibited strongest binding affinity than its analogues. Moreover, the antiproliferative properties of all compounds in vitro in human cancer cell line (A549 and H-1975 lung cancer cells, HepG2 human hepatocarcinoma, T47D breast cancer cells) and noncancerous cell line (Hs 578Bst normal breast cells) have also been evaluated by MTT assay. Besides, an extracted method was carried out to determine the cellular uptake ability of three complexes to the tested cancer cell lines. The cytotoxicity and cellular uptake tests revealed that CuP3 exhibited the best antiproliferative activity as well as cellular absorption capacity towards H-1975 cell line. In order to better understand the effects of CuP3 on H-1975 cells, the fluorescence microscopy measurements were employed, the cell membrane damage, nuclear condensation, and apoptotic bodies (brighter fluorescence) were markedly observed after incubated with CuP3 for 48 h, suggesting that CuP3 can induce cell apoptosis on H-1975 cells significantly. In addition, the flow cytometric analysis results illustrated that the complex CuP3 mainly caused an accumulation of cells in the G2 phase of the cell cycle. Graphical abstract Image 1 Highlights • Three water-soluble Cu(Ⅱ)-based acylhydrazone porphyrin derivatives have been firstly synthesized. • CuP3 has strongest DNA-binding affinity due to its fluorine atoms in Schiff base moiety. • All complexes showed good cytotoxicity for cancer cells but weak for normal cells. • CuP3 revealed the best antiproliferative activity and cellular uptake towards H-1975 cell line. • CuP3 could induce H-1975 cell apoptosis significantly and arrest G2 phase cells. [ABSTRACT FROM AUTHOR]

Abstract Developing new hole transport material is still paramount to improve the whole stability of perovskite solar cells (PSCs). Here, an acylhydrazone-based porphyrin derivative was used as HTM to prepare PSC. Due to the efficient electronic passivation of under-coordinated Pb atoms in perovskite by acylhydrazone together with the pyridine-terminated groups, the best efficiency was readily improved up to 17.8%. The corresponding PSC device also revealed improved water stability, especially for the enhancement of thermal stability. These findings open the opportunities for design new HTMs based on porphyrin derivatives in efficient and stable PSCs. Graphical abstract An acylhydrazone-based porphyrin derivative was used as HTM to prepare PSC. Due to the efficient electronic passivation of under-coordinated Pb atoms in perovskite by acylhydrazone together with the pyridine-terminated groups, the best efficiency was readily improved up to 17.8%. The corresponding PSC device also revealed improved water stability, especially for the enhancement of thermal stability. Image 1 Highlights • An acylhydrazone-based porphyrin derivative was used as HTM to prepare PSC. • The ZnPy can efficient passivate the under-coordinated Pb atoms in perovskite. • The corresponding PSC device revealed improved water and thermal stability. [ABSTRACT FROM AUTHOR]

Tetrad novel Cu-complex containing multifarious meso-10,15,20-Tris (N-methyl-2′-pyridyl)-5-(4′- X- acylhydrazone) porphyrin ligands, where X respectively referred to salicylaldehyde ( Cu-P1 ), o-Vanillin ( Cu-P2 ), pyridine-2-carboxaldehyde ( Cu-P3 ) and acetone ( Cu-P4 ), have been successfully isolated and well characterized. Multiple physicochemical approaches reveal the complex Cu-P4 with preferable binding affinity than its analogues due to smaller molecular dimension. Moreover, the mechanism of the anti-neoplasm action of these conjugates have been appraised via MTT assay, manifesting all of them possess superior cytotoxicity towards A549 (non-small cell lung cancer) and HepG2 (liver hepatocellular carcinoma cells) but weak cell toxicity for Hs 578Bst (human normal breast cells) which might be boiled down to porphyrin derivatives could enrich around malignant neoplasms. The flow cytometric analysis illustrates that delegate compound Cu-P4 induced cell death predominantly through late apoptosis and arrested S phase cells. [ABSTRACT FROM AUTHOR]