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The reduction of the runoff to lake has become a common phenomenon of the inland lakes in northwest China, and the quantitative calculation of the driving factors affecting the runoff change has always been a challenge in lake research. In this pursuit, the present study was performed on Lake Daihai as an example, based on the relevant data from 1960 to 2018. The quantitative calculations of the runoff driving factors of Lake Daihai from 1982 to 2004 and from 2004 to 2017 were based on the slope change ratio of cumulative quantity (SCRCQ). It was concluded that human activities were the main factors affecting runoff change after 1982. The SCRCQ method was improved, which could carry out the quantitative calculations on the driving factors affecting the runoff change of the Lake Daihai from 1961 to 2017 on a yearly basis. The results show that the dominant factor of runoff changes in Lake Daihai was found to be the climate change before 1975, and it changed into human activities after 1975. Finally, based on the comparative analysis of the results of SCRCQ and improved SCRCQ, the advantages of improved SCRCQ were discussed. In addition, the reasons for the variation of the runoff to lake dominated by different factors in different periods for Lake Daihai were analyzed. Key Points: This paper analyzes the influence of climate change and human activities on the change in runoff volume of Lake Daihai according to the slope change ratio of cumulative quantity (SCRCQ)The SCRCQ method was improved, which could carry out the quantitative calculations on the driving factors affecting the runoff change of the Lake Daihai from 1961 to 2017 on a yearly basisThe reasons for the variation of the runoff to lake dominated by different factors in different periods for Lake Daihai were analyzed [ABSTRACT FROM AUTHOR]