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The Central Asian Orogenic Belt (CAOB) was generated through multiple collisional and accretionary events in the Paleo-Asian Ocean, a major global ocean that existed from the late Neoproterozoic into the late Paleozoic. Nevertheless, the question of when the Paleo-Asian Ocean finally closed has notoriously been enigmatic, especially due to the absence of large-scale investigations. The South Tianshan-Solonker Suture, is the largest and southernmost suture within the CAOB, and records the ultimate collision between the Tarim-North China cratons with the Siberia craton, and is commonly interpreted as marking the eventual closure of the Paleo-Asian Ocean. In this paper, we synthesize and evaluate relevant Chinese papers on the area, which are not readily available to an international audience, and extend this across the full length of the suture zone. Based on this review, we can divide the suture zone into four distinct segments, which are, from west to east: the South Tianshan Belt, the Beishan Belt, the Solonker Belt and the Yanji Belt. This enables us to provide a more systematic understanding of the nature and development of the South Tianshan-Solonker suture. Geochronological data from Paleozoic cover rocks and high-pressure metamorphic rocks show that during the late Carboniferous, the western section of the Paleo-Asian Ocean closed when the Tarim Craton moved northward to collide with the Kazakhstan-Yili Block, thus marking the initial development of the South Tianshan Belt. The Beishan Belt to the east formed when the Dunhuang-Alxa blocks were transported northward to collide with the Tuva-Mongolia Block, with the youngest zircon U Pb data from ophiolites indicating that closure of the local Beishan Ocean was in the early-middle Permian, although its final closure may not have been until the early late Permian along the northern margin of the Alxa Block, thus making it slightly younger than the South Tianshan Belt. Further to the east, the available petrographic, geochronological and paleontological data from the Solonker Belt indicate that this belt was formed in the middle-late Permian, during which time bi-directional subduction occurred and the North China and Siberia cratons were amalgamated during an 'Appalachian-type' orogeny. Furthermore, we observe that a transition in polarity from northward to bi-directional subduction occurred along the boundary between the Beishan and Solonker belts, which may be related to the East Gobi Transform Fault. In contrast, under the influence of the westward subduction of the Paleo-Pacific Ocean, the Jiamusi-Khanka Block moved southwestward along the Yilan-Yitong Fault in the middle-late Triassic (230–220 Ma) to amalgamate with the North China Craton. The formation of the South Tianshan-Solonker Suture can be characterized by four distinct west-to-east accretion/collision events that lasted from the late Carboniferous to the late Permian. The South Tianshan Belt, the Beishan Belt and the Solonker Belt therefore demarcate, respectively, the amalgamation between the Tarim Craton and the Kazakhstan-Yili Block, the Dunhuang-Alxa Block and the Tuva-Mongolia Block, and the North China Craton with the Siberia Craton, representing the final closure of the Paleo-Asian Ocean. During the middle-late Triassic, the Yanji Belt in the far east was influenced by the Paleo-Pacific tectonic domain as a result of amalgamation between the Jiamusi-Khanka Block and the North China Craton. • South Tianshan-Solonker Suture marks the final collision between Tarim-North China and Siberian cratons. • The Suture includes four segments, and closed form Late Carboniferous to Middle Triassic from west to east, respectively. • The Yanji belt was influenced by the Paleo-Pacific tectonic domain during the Middle Triassic. [ABSTRACT FROM AUTHOR]