1. Lipid ratios representing SCD1, FADS1, and FADS2 activities as candidate biomarkers of early growth and adiposity
- Author
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L. Olga, J.A. van Diepen, I. Bobeldijk-Pastorova, G. Gross, P.M. Prentice, S.G. Snowden, S. Furse, T. Kooistra, I.A. Hughes, M.H. Schoemaker, E.A.F. van Tol, W. van Duyvenvoorde, P.Y. Wielinga, K.K. Ong, D.B. Dunger, R. Kleemann, and A. Koulman
- Subjects
Lipid ratio ,SCD1 ,FADS ,Infant growth ,Adiposity ,Desaturase ,Medicine ,Medicine (General) ,R5-920 - Abstract
Background: Altered lipid metabolism in early life has been associated with subsequent weight gain and predicting this could aid in obesity prevention and risk management. Here, a lipidomic approach was used to identify circulating markers for future obesity risk in translational murine models and validate in a human infant cohort. Methods: Lipidomics was performed on the plasma of APOE*3 Leiden, Ldlr-/-.Leiden, and the wild-type C57BL/6J mice to capture candidate biomarkers predicting subsequent obesity parameters after exposure to high-fat diet. The identified candidate biomarkers were mapped onto corresponding lipid metabolism pathways and were investigated in the Cambridge Baby Growth Study. Infants’ growth and adiposity were measured at 0-24 months. Capillary dried blood spots were sampled at 3 months for lipid profiling analysis. Findings: From the mouse models, cholesteryl esters were correlated with subsequent weight gain and other obesity parameters after HFD period (Spearman's r≥0.5, FDR p values
- Published
- 2021
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