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Objectives: A new, accelerated dobutamine-atropine stress echocardiography (DASE) protocol (baseline 20 mcg/kg/min; 40 mcg/kg/min) was compared with a standard protocol in patients with suspected coronary artery disease (CAD) to evaluate tolerability, length of infusion, and overall test times, as well as safety., Methods: Patients received the DASE or the standard protocol on an alternating basis (n = 164)., Results: Total test time, including patient recovery (HR < 100 bpm), dropped from an average of 19:23-12:12 min (p < 0.0001). Average symptom duration decreased from 5:50 to 3:17 min (p < 0.01). Women had shorter total test times in both accelerated and standard protocols compared to that of men., Conclusions: The accelerated DASE protocol is a well tolerated alternative to standard dobutamine stress testing allowing practitioners to reduce test times without increasing the incidence of arrhythmias. Patients in the accelerated arm also had shorter duration of symptoms.

Study Objectives: Transesophageal echocardiography (TEE) has a high sensitivity for the diagnosis of infective endocarditis (IE), but the prospective role of TEE when added to a careful clinical examination has not been well-studied., Design: We compared the results of TEE to a clinical evaluation by an infectious disease specialist in 43 consecutive patients in whom TEE was ordered to rule out IE. Prior to TEE, the patients were classified on clinical grounds as to their likelihood of IE using a modification of the von Reyn criteria. Changes in management occurring as a result of TEE also were evaluated., Measurements and Results: TEE was positive in 11 patients, negative in 29, and indeterminate in 3. TEE was positive in 6 (46%) of 13 high probability patients, 2 (67%) of medium probability patients, and 3 (11%) of 27 low probability patients. A change in management based on TEE occurred in 4 (31%) patients with high probability, in no patients with medium probability, and in 1 (4%) patient with low probability., Conclusions: TEE confirms IE in patients with high probability of IE and often leads to a management change. However, TEE is unlikely to establish the diagnosis or change management in patients with low probability.

The diagnosis of nonbacterial thrombotic endocarditis is rarely made during life. We describe a patient with non-Hodgkin's lymphoma with evidence of systemic embolism in which transesophageal echocardiography was useful in establishing the diagnosis. The clinical and echocardiographic features of nonbacterial thrombotic endocarditis should be remembered when a valvular mass is seen on echocardiography.

Transesophageal echocardiography (TEE) is an invaluable diagnostic tool, particularly in patients with inadequate transthoracic echocardiographic examinations. In addition, continuous TEE has been used to monitor ventricular and valvular performance in the intensive care unit and the operating room. However, current generation transesophageal probes have limitations in the critical care setting due to their size. Recently, a prototype miniaturized transesophageal probe was developed to overcome these limitations. This probe was used by five medical centers for 194 examinations. A large proportion of these patients were in the intensive care unit (43%), as well as mechanically ventilated (39%). Seventy percent (70%) of the subjects in this study were intubated nasally with the prototype probe, with a success rate of 88.5%. Oral intubation was successful in every case. Subject tolerance was good, and 25% of the patients were intubated for > 1 h. Nasal intubation with the probe was more likely in intensive care patients, ventilated subjects, and patients who were intubated for > 1 hour. TEE with this miniaturized probe is feasible and safe even in multi-instrumented critical care patients. This probe provides adequate diagnostic imaging capabilities and may allow imaging over prolonged periods of time, making it suitable for the serial monitoring of ventricular performance.

Since its advent, the use of transesophageal echocardiography (TEE) has grown rapidly. In patients undergoing TEE in the intensive care unit over two time periods (4 years apart), we evaluated whether TEE led to new/unsuspected findings or changes in patient management. Results showed that the indications for which patients underwent TEE changed considerably between the two time periods. Hemodynamic instability was an indication for TEE in 41% of the patients in the first interval and 56% of the patients in the second interval. TEE frequently established a new diagnosis (41%) and led to significant management changes (28%) in both time periods. These changes occurred despite the use of a pulmonary artery catheter in nearly 2/3 of the patients studied. Therefore, despite increasing and changing use, TEE frequently establishes unsuspected diagnosis and directly influences patient management when used in intensive care patients.

Acute massive pulmonary embolus (PE) when undiagnosed may lead to hemodynamic compromise and death. Echocardiography offers several clues to the diagnosis of PE. We describe how transesophageal echo was used in the diagnosis and management of two patients with this disorder.