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Introduction: Biodiversity and biodiversity-based ecosystems services are intrinsically dependent on the climate. During the twentieth century, climate change has posed major threats to biodiversity in Africa, and impacts are expected to increase as climate change continues and perhaps even accelerates.Outcomes: Our review shows that the multiple components of climate change are projected to affect all levels of biodiversity, from genes over species to biome level. Loss of biodiversity as a result of climate change can alter the structures and functions of African ecological systems. As a result, the provision of biodiversity-based ecosystem services and the well-being of people that rely on these services are being modified. Of particular concerns are “tipping points” where the exceedance of ecosystem thresholds will possibly lead to irreversible shifts of the structure of ecosystems and their services. In recent years, climate prediction models have portended continued warming and more frequent extreme weather events across the region. Such weather-related disturbances such as El Niño will place a premium on biodiversity and biodiversity-based ecosystem services that people rely on.Conclusion: As biodiversity underlies all goods and services provided by ecosystems that are crucial for human survival and well-being, this paper synthesizes and discusses observed and anticipated impacts of climate change on biodiversity and biodiversity-based ecosystem service provision and livelihoods, and what strategies might be employed to decrease current and future risks on the well-being of human in Africa.