1. Extensive myelitis with eosinophilic meningitis after Chimeric antigen receptor T cells therapy
- Author
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Baptiste Le Calvez, Marion Eveillard, Paul Decamps, Jesus Aguilar, Amélie Seguin, Emmanuel Canet, Audrey Grain, Cyrille Touzeau, Benoît Tessoulin, and Thomas Gastinne
- Subjects
Chimeric antigen receptor T cells ,eosinophilic meningitis ,eosinophilic pleocytosis ,mantle cell lymphoma ,myelitis ,Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Abstract Immune effector cell‐associated neurotoxicity syndrome (ICANS) is a frequent adverse event after Chimeric antigen receptor T cells (CAR‐T cells). A patient treated with anti‐CD19 CAR‐T cells for a refractory mantle cell lymphoma presented at Day 8 post‐infusion with extensive myelitis. Unusual eosinophilia was disclosed in the patient's cerebrospinal fluid. After treatment with methylprednisolone and siltuximab, a decrease in clinical symptoms and magnetic resonance imaging lesions were obtained. This unprecedented presentation of eosinophilic meningitis after CAR‐T cells therapy highlights the need for a better understanding of the physiopathology of ICANS, especially to identify potentially targetable pathways.
- Published
- 2022
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