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Your search keyword '"Dulski, K."' showing total 5 results
Start Over Author "Dulski, K." Journal ejnmmi physics
5 results on '"Dulski, K."'

1. Comparative studies of the sensitivities of sparse and full geometries of Total-Body PET scanners built from crystals and plastic scintillators

Author

Dadgar, M., Parzych, S., Baran, J., Chug, N., Curceanu, C., Czerwiński, E., Dulski, K., Elyan, K., Gajos, A., Hiesmayr, B. C., Kapłon, Ł., Klimaszewski, K., Konieczka, P., Korcyl, G., Kozik, T., Krzemien, W., Kumar, D., Niedzwiecki, S., Panek, D., Perez del Rio, E., Raczyński, L., Sharma, S., Shivani, S., Shopa, R. Y., Skurzok, M., Stepień, E. Ł., Tayefi Ardebili, F., Tayefi Ardebili, K., Vandenberghe, S., Wiślicki, W., and Moskal, P.

Published
2023
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2. Efficiency determination of J-PET: first plastic scintillators-based PET scanner

Author

Sharma, S., Baran, J., Chug, N., Curceanu, C., Czerwiński, E., Dadgar, M., Dulski, K., Eliyan, K., Gajos, A., Gupta-Sharma, N., Hiesmayr, B. C., Kacprzak, K., Kapłon, Ł., Klimaszewski, K., Konieczka, P., Korcyl, G., Kozik, T., Krzemień, W., Kumar, D., Niedźwiecki, Sz., Panek, D., Parzych, S., del Rio, E. Perez, Raczyński, L., Choudhary, Shivani, Shopa, R. Y., Skurzok, M., Stępień, E. Ł., Tayefi, F., Tayefi, K., Wiślicki, W., and Moskal, P.

Published
2023
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3. Estimating relationship between the time over threshold and energy loss by photons in plastic scintillators used in the J-PET scanner

Author

Sharma, S., Chhokar, J., Curceanu, C., Czerwiński, E., Dadgar, M., Dulski, K., Gajewski, J., Gajos, A., Gorgol, M., Gupta-Sharma, N., Del Grande, R., Hiesmayr, B.C., Jasińska, B., Kacprzak, K., Kapłon, Ł., Karimi, H., Kisielewska, D., Klimaszewski, K., Korcyl, G., Kowalski, P., Kozik, T., Krawczyk, N., Krzemień, W., Kubicz, E., Mohammed, M., Niedzwiecki, Sz., Pałka, M., Pawlik-Niedźwiecka, M., Raczyński, L., Raj, J., Ruciński, A., Shivani, S., Shopa, R.Y., Silarski, M., Skurzok, M., Stępień, E.Ł., Wiślicki, W., Zgardzińska, B., and Moskal, P.

Published
2020
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4. Performance assessment of the 2 γpositronium imaging with the total-body PET scanners

Author

Moskal, P., Kisielewska, D., Y. Shopa, R., Bura, Z., Chhokar, J., Curceanu, C., Czerwiński, E., Dadgar, M., Dulski, K., Gajewski, J., Gajos, A., Gorgol, M., Del Grande, R., C. Hiesmayr, B., Jasińska, B., Kacprzak, K., Kamińska, A., Kapłon, Ł, Karimi, H., Korcyl, G., Kowalski, P., Krawczyk, N., Krzemień, W., Kozik, T., Kubicz, E., Małczak, P., Mohammed, M., Niedźwiecki, Sz., Pałka, M., Pawlik-Niedźwiecka, M., Pędziwiatr, M., Raczyński, L., Raj, J., Ruciński, A., Sharma, S., Shivani, S., Silarski, M., Skurzok, M., Stępień, E. Ł., Vandenberghe, S., Wiślicki, W., and Zgardzińska, B.

Subjects
lcsh:Medical physics. Medical radiology. Nuclear medicine, PET, Total-body PET, lcsh:R895-920, Medical imaging, Positronium imaging, Original Research
Abstract

Purpose In living organisms, the positron-electron annihilation (occurring during the PET imaging) proceeds in about 30% via creation of a metastable ortho-positronium atom. In the tissue, due to the pick-off and conversion processes, over 98% of ortho-positronia annihilate into two 511 keV photons. In this article, we assess the feasibility for reconstruction of the mean ortho-positronium lifetime image based on annihilations into two photons. The main objectives of this work include the (i) estimation of the sensitivity of the total-body PET scanners for the ortho-positronium mean lifetime imaging using 2γ annihilations and (ii) estimation of the spatial and time resolution of the ortho-positronium image as a function of the coincidence resolving time (CRT) of the scanner. Methods Simulations are conducted assuming that radiopharmaceutical is labeled with 44 S c isotope emitting one positron and one prompt gamma. The image is reconstructed on the basis of triple coincidence events. The ortho-positronium lifetime spectrum is determined for each voxel of the image. Calculations were performed for cases of total-body detectors build of (i) LYSO scintillators as used in the EXPLORER PET and (ii) plastic scintillators as anticipated for the cost-effective total-body J-PET scanner. To assess the spatial and time resolution, the four cases were considered assuming that CRT is equal to 500 ps, 140 ps, 50 ps, and 10 ps. Results The estimated total-body PET sensitivity for the registration and selection of image forming triple coincidences (2γ+γ prompt) is larger by a factor of 13.5 (for LYSO PET) and by factor of 5.2 (for plastic PET) with respect to the sensitivity for the standard 2γ imaging by LYSO PET scanners with AFOV = 20 cm. The spatial resolution of the ortho-positronium image is comparable with the resolution achievable when using TOF-FBP algorithms already for CRT = 50 ps. For the 20-min scan, the resolution better than 20 ps is expected for the mean ortho-positronium lifetime image determination. Conclusions Ortho-positronium mean lifetime imaging based on the annihilations into two photons and prompt gamma is shown to be feasible with the advent of the high sensitivity total-body PET systems and time resolution of the order of tens of picoseconds.

Published
2020

5. Developing a novel positronium biomarker for cardiac myxoma imaging.

Author

Moskal P, Kubicz E, Grudzień G, Czerwiński E, Dulski K, Leszczyński B, Niedźwiecki S, and Stępień EŁ

Abstract

Purpose: Cardiac myxoma (CM), the most common cardiac tumor in adults, accounts for 50-75% of benign cardiac tumors. The diagnosis of CM is often elusive, especially in young stroke survivors and transthoracic echocardiography (TTE) is the initial technique for the differential diagnostics of CM. Less invasive cardiac computed tomography (CT) and magnetic resonance imaging (MRI) are not available for the majority of cardiac patients. Here, a robust imaging approach, ortho-Positronium (o-Ps) imaging, is presented to determine cardiac myxoma extracted from patients undergoing urgent cardiac surgery due to unexpected atrial masses. We aimed to assess if the o-Ps atom, produced copiously in intramolecular voids during the PET imaging, serves as a biomarker for CM diagnosing., Methods: Six perioperative CM and normal (adipose) tissue samples from patients, with primary diagnosis confirmed by the histopathology examination, were examined using positron annihilation lifetime spectroscopy (PALS) and micro-CT. Additionally, cell cultures and confocal microscopy techniques were used to picture cell morphology and origin., Results: We observed significant shortening in the mean o-Ps lifetime in tumor with compare to normal tissues: an average value of 1.92(02) ns and 2.72(05) ns for CM and the adipose tissue, respectively. Microscopic differences between tumor samples, confirmed in histopathology examination and micro-CT, did not influenced the major positronium imaging results., Conclusions: Our findings, combined with o-Ps lifetime analysis, revealed the novel emerging positronium imaging marker (o-PS) for cardiovascular imaging. This method opens the new perspective to facilitate the quantitative in vivo assessment of intracardiac masses on a molecular (nanoscale) level., (© 2023. The Author(s).)

Published
2023
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