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Background: Texture features are being increasingly evaluated in F-fluorodeoxyglucose positron emission tomography (F-FDG PET) as adjunctive imaging biomarkers in a number of different cancers. Whilst studies have reported repeatability between scans, there have been no studies that have specifically investigated the effect that the time of acquisition post-injection of F-FDG has on texture features. The aim of this study was to investigate if texture features change between scans performed at different time points post-injection. Results: Fifty-four patients (30 male, 24 female, mean age 35.1 years) with neurofibromatosis-1 and suspected malignant transformation of a neurofibroma underwent F-FDG PET/computed tomography (CT) scans at 101.5 ± 15.0 and 251.7 ± 18.4 min post-injection of 350 MBq F-FDG to a standard clinical protocol. Following tumour segmentation on both early and late scans, first- ( n = 37), second- ( n = 25) and high-order ( n = 31) statistical features, as well as fractal texture features ( n = 6), were calculated and a comparison was made between the early and late scans for each feature. Of the 54 tumours, 30 were benign and 24 malignant on histological analysis or on clinical follow-up for at least 5 years. Overall, 25/37 first-order, 9/25 second-order, 13/31 high-order and 3/6 fractal features changed significantly ( p < 0.05) between early and late scans. The corresponding proportions for the 30 benign tumours alone were 22/37, 7/25, 8/31 and 2/6 and for the 24 malignant tumours, 11/37, 6/25, 8/31 and 0/6, respectively. Conclusions: Several texture features change with time post-injection of F-FDG. Thus, when comparing texture features in intra- and inter-patient studies, it is essential that scans are obtained at a consistent time post-injection of F-FDG. [ABSTRACT FROM AUTHOR]