1. [Antianemic effect of reamberin in rats with acute alloxan-induced diabetes].
- Author
-
Volchegorskiĭ IA, Tishevskaia NV, and Dement'eva EV
- Subjects
- Alloxan, Anemia blood, Animals, Blood Cell Count, Bone Marrow drug effects, Diabetes Mellitus, Experimental complications, Diabetes Mellitus, Experimental drug therapy, Female, Male, Meglumine administration & dosage, Rats, Anemia drug therapy, Diabetes Mellitus, Experimental blood, Erythropoiesis drug effects, Meglumine therapeutic use
- Abstract
The influence of reamberin on hematological indices in the acute period of alloxan-induced diabetes has been studied. It is established that anemia develops within 72 hours after alloxan injection at a diabetogenic dose in rats, which is related to bone marrow erythropoiesis suppression and is accompanied by inflammatory leukocytosis. Single administration of reamberin in a dose equivalent to the human therapeutic dose produces correction of the leukocyte content in the blood, normalizes the bone marrow erythropoiesis, and prevents anemia development in rats with alloxan-induced diabetes. The antianemic action of reamberin is not related to its influence on carbohydrate metabolism in experimental diabetes mellitus.
- Published
- 2008