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The significance of Technological and Vocational Education (TVE) lies in producing professionals with competencies that are required to support the academic community. The aim of this study was to build an Information System of Laboratory (ISLab) that would improve the performance of the technical and vocational educational laboratory. The proposed information system was built based on multimedia featuring text, graphics, 3D images, grassroots access, and top-down reviews. The study used the System Development Life Cycle (SDLC) technique, and the data was analyzed using descriptive, gain-score, and inferential factorial design. The study findings proved that ISLab operated in accordance with laboratory standards and achieved a performance of 90.3% according to user needs. Furthermore, laboratory management using ISLab was found more effective than conventional management system, and the proposed method of management enabled interaction with user groups that led to an increase in performance of laboratory staff and lecturers. The results of this research indicate that ISLab was suitable to be used in managing technical and vocational educational laboratories. [ABSTRACT FROM AUTHOR]