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1 results on '"ZHU Jun"'

1. Molecular beacon structure mediated rolling circle amplification for ultrasensitive electrochemical detection of microRNA based on quantum dots tagging.

Author

Wang, Danchen, Hu, Lihui, Zhou, Huiming, Abdel-Halim, E.S., and Zhu, Jun-Jie

Subjects
*ELECTROCHEMICAL sensors, *MOLECULAR structure, *GENE amplification, *MICRORNA, *QUANTUM dots, *BIOMARKERS, *CHRONIC lymphocytic leukemia, *CANCER cells
Abstract

Abstract: MicroRNA-16 (miR-16) frequently deleted or downregulated in patients with B cell chronic lymphocytic leukemia and thus can be used as promising biomarkers in B-CLL diagnosis and prognosis. Herein, an ultrasensitive miR-16 detection was carried out by combining rolling circle amplification (RCA), quantum dots tagging and anodic stripping voltammetric detection (ASV). The method could specifically quantify miR-16 over a 6-decade dynamic range and reach an ultra-low detection limit of 0.32 aM. [Copyright &y& Elsevier]

Published
2013
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