1. Time-constant-based CMOS readout circuit for DNA detection
- Author
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Y. Fan, T.H. Teo, W.G. Yeoh, K.-L. Oung, X.T. Chen, and Zhiqiang Gao
- Subjects
Conductive polymer ,Materials science ,business.industry ,Capacitive sensing ,Time constant ,Capacitance ,Nanoelectronics ,CMOS ,Sensor array ,Electronic engineering ,Optoelectronics ,Electrical and Electronic Engineering ,business ,Biosensor - Abstract
An RC-to-time constant interface circuit was implemented in 0.18 µm CMOS to characterise the conductive polymer labelled deoxyribonucleic acid (DNA) hybridisation activity on nano-sensor micro-arrays. Measured results show that sub-picomolar DNA (0.1–10 pM) are able to be differentiated with respect to their electrical parameters of 1–23 GΩ resistances parallel with 2.8 down to 0.1 nF capacitances.
- Published
- 2008
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