1. Autophagy in major human diseases.
- Author
-
Klionsky, Daniel J, Petroni, Giulia, Amaravadi, Ravi K, Baehrecke, Eric H, Ballabio, Andrea, Boya, Patricia, Bravo‐San Pedro, José Manuel, Cadwell, Ken, Cecconi, Francesco, Choi, Augustine M K, Choi, Mary E, Chu, Charleen T, Codogno, Patrice, Colombo, Maria Isabel, Cuervo, Ana Maria, Deretic, Vojo, Dikic, Ivan, Elazar, Zvulun, Eskelinen, Eeva‐Liisa, and Fimia, Gian Maria
- Subjects
GENETIC engineering ,DRUG therapy ,PATHOGENESIS ,HUMAN beings - Abstract
Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy‐related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF