1. Endosome maturation.
- Author
-
Huotari J and Helenius A
- Subjects
- ADP-Ribosylation Factor 1 metabolism, Autophagy physiology, Coat Protein Complex I metabolism, Endosomes ultrastructure, Exosomes metabolism, GTP Phosphohydrolases metabolism, Humans, Lysosomes metabolism, Lysosomes ultrastructure, rab GTP-Binding Proteins metabolism, Endocytosis physiology, Endosomes metabolism
- Abstract
Being deeply connected to signalling, cell dynamics, growth, regulation, and defence, endocytic processes are linked to almost all aspects of cell life and disease. In this review, we focus on endosomes in the classical endocytic pathway, and on the programme of changes that lead to the formation and maturation of late endosomes/multivesicular bodies. The maturation programme entails a dramatic transformation of these dynamic organelles disconnecting them functionally and spatially from early endosomes and preparing them for their unidirectional role as a feeder pathway to lysosomes.
- Published
- 2011
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