1. Epidemiology and clinical features of emergency department patients with suspected <scp>COVID</scp> ‐19: Insights from Australia's ‘second wave’ ( <scp>COVED</scp> ‐4)
- Author
-
Biswadev Mitra, Nicole Lowry, Muhuntha Sri-Ganeshan, Carolyne Sevior, Rob Mitchell, Jeremy Furyk, Max Raos, Samuel Baker, De Villiers Smit, Sherman Siu, Anselm Wong, Sophie Parker, Jonathan C Knott, Nicole Chapman, Michael P Noonan, Vinay Gangathimmaiah, Erica Chatterton, Ashley Loughman, Viet Tran, Gerard O'Reilly, Paul Buntine, Dylan Freeman, Hamed Akhlaghi, and Peter Cameron
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Pneumonia, Viral ,Odds ,Patient Isolation ,03 medical and health sciences ,COVID-19 Testing ,0302 clinical medicine ,Internal medicine ,Epidemiology ,Sore throat ,medicine ,Humans ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,Pandemics ,Mechanical ventilation ,SARS-CoV-2 ,business.industry ,Australia ,COVID-19 ,030208 emergency & critical care medicine ,Odds ratio ,Emergency department ,Middle Aged ,16. Peace & justice ,Respiration, Artificial ,Confidence interval ,3. Good health ,Emergency Medicine ,Female ,medicine.symptom ,Emergency Service, Hospital ,business - Abstract
Objective: The aim of the present study was to describe the epidemiology and clinical features of patients presenting to the ED with suspected and confirmed COVID-19 during Australia's 'second wave'. Methods: The COVID-19 ED (COVED) Project is an ongoing prospective cohort study in Australian EDs. This analysis presents data from 12 sites across four Australian states for the period from 1 July to 31 August 2020. All adult patients who met the criteria for 'suspected COVID-19' and underwent testing for SARS-CoV-2 in the ED were eligible for inclusion. Study outcomes included a positive SARS-CoV-2 test result, mechanical ventilation and in-hospital mortality. Results: There were 106 136 presentations to the participating EDs and 12 055 (11.4%; 95% confidence interval [CI] 11.2-11.6) underwent testing for SARS-CoV-2. Of these, 255 (2%) patients returned a positive result. Among positive cases, 13 (5%) received mechanical ventilation during their hospital admission compared to 122 (2%) of the SARS-CoV-2 negative patients (odds ratio 2.7; 95% CI 1.5-4.9, P = 0.001). Nineteen (7%) SARS-CoV-2 positive patients died in hospital compared to 212 (3%) of the SARS-CoV-2 negative patients (odds ratio 2.3; 95% CI 1.4-3.7, P = 0.001). Strong clinical predictors of the SARS-CoV-2 test result included self-reported fever, sore throat, bilateral infiltrates on chest X-ray, and absence of a leucocytosis on first ED blood tests (P Conclusions: In this prospective multi-site study during Australia's 'second wave', a substantial proportion of ED presentations required SARS-CoV-2 testing and isolation. Presence of SARS-CoV-2 on nasopharyngeal swab was associated with an increase in the odds of death and mechanical ventilation in hospital.
- Published
- 2021