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Purpose. Outbreaks caused by infectious diseases are now serious public health events. At present, most hospitals have a high number of fever clinic attendances. In order to improve the efficiency of fever clinic screening, timely detection and control of infection sources, early detection, early isolation, and early treatment, our hospital explored the construction and effect of our fever clinic management model during the response period by constructing a fever clinic regular management model based on the principles of infection control. Methods. 1300 cases (September 2021 to February 2022) with or without epidemiological history were divided into the control group (without epidemiological history) and the observation group (with epidemiological history) and patients were given differentiated management. A model of permanent management of a fever clinic during the epidemic was set up and evaluated by implementing the person responsible for epidemic positions, optimizing tertiary care, and strengthening nosocomial infection protection for health care workers. Results. The results showed that patients in the observation group had a lower age of onset, a longer consultation time, and a higher proportion of patients with fever, which was different from the control group (P < 0.05). Compared with the control group, the proportion of routine blood tests, the proportion of four respiratory virus tests, and the per capita cost were higher in the observation group, and the differences were statistically significant (P < 0.05). There were no missed diagnoses, underreporting, cross-infections, or nosocomial infections in either group, and there were no significant differences between the two groups in terms of patients' evaluation of management quality and satisfaction with management (P > 0.05). The skill level, management attitude, and standardized operation of outpatient clinic managers improved after the construction of a fever clinic standing management model based on infection control, and the recognition of patients was higher in the observation group (P < 0.05). Conclusion. The construction of a fever outpatient routine management model based on the principle of infection control is conducive to the standardized implementation of the management and treatment of health care workers, early detection of the source of transmission to cut off the transmission route, avoiding cross-infection and nosocomial infection, and ensuring the safety of patients and health care workers. [ABSTRACT FROM AUTHOR]