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Start Over Author "Aung Si Thu" Journal emerging infectious diseases
4 results on '"Aung Si Thu"'

1. Genomic Profiling of Mycobacterium tuberculosis Strains, Myanmar

Author

Aung, Htin Lin, Nyunt, Wint Wint, Fong, Yang, Biggs, Patrick J., Winkworth, Richard C., Lockhart, Peter J., Yeo, Tsin Wen, Hill, Philip C., Cook, Gregory M., and Aung, Si Thu

Subjects
Drug resistance in microorganisms -- Genetic aspects, Tuberculosis -- Causes of -- Genetic aspects -- Drug therapy, Mycobacterium tuberculosis -- Identification and classification -- Genetic aspects, Health
Abstract

Tuberculosis (TB) is the infectious disease that causes the most deaths worldwide ([approximately equal to] 5,000/day) (1). Of major concern is the increasing prevalence of drug resistance worldwide (1). There [...]

Published
2021
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2. Genomic Profiling of Mycobacterium tuberculosis Strains, Myanmar.

Author

Htin Lin Aung, Wint Wint Nyunt, Yang Fong, Biggs, Patrick J., Winkworth, Richard C., Lockhart, Peter J., Tsin Wen Yeo, Hill, Philip C., Cook, Gregory M., Si Thu Aung, Aung, Htin Lin, Nyunt, Wint Wint, Fong, Yang, Yeo, Tsin Wen, and Aung, Si Thu

Subjects
MYCOBACTERIUM tuberculosis, MULTIDRUG-resistant tuberculosis, ORAL medication, DIAGNOSIS, NUCLEOTIDE sequencing, MULTIDRUG resistance, RESEARCH, RESEARCH methodology, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, GENOMICS, RIFAMPIN, DRUG resistance in microorganisms, MICROBIAL sensitivity tests
Abstract

Multidrug resistance is a major threat to global elimination of tuberculosis (TB). We performed phenotypic drug-susceptibility testing and whole-genome sequencing for 309 isolates from 342 consecutive patients who were given a diagnosis of TB in Yangon, Myanmar, during July 2016‒June 2018. We identified isolates by using the GeneXpert platform to evaluate drug-resistance profiles. A total of 191 (62%) of 309 isolates had rifampin resistance; 168 (88%) of these rifampin-resistant isolates were not genomically related, indicating the repeated emergence of resistance in the population, rather than extensive local transmission. We did not detect resistance mutations to new oral drugs, including bedaquiline and pretomanid. The current GeneXpert MTB/RIF system needs to be modified by using the newly launched Xpert MTB/XDR cartridge or line-probe assay. Introducing new oral drugs to replace those currently used in treatment regimens for multidrug-resistant TB will also be useful for treating TB in Myanmar. [ABSTRACT FROM AUTHOR]

Published
2021
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4. Acquired Resistance to Antituberculosis Drugs.

Author

Htin Lin Aung, Wint Wint Nyunt, Yang Fong, Russell, Bruce, Cook, Gregory M., Si Thu Aung, Aung, Htin Lin, Nyunt, Wint Wint, Fong, Yang, and Aung, Si Thu

Subjects
DRUG resistance, TUBERCULOSIS, ANTITUBERCULAR agents, COMPARATIVE studies, RESEARCH methodology, MEDICAL cooperation, RESEARCH, EVALUATION research
Published
2018
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