1. Acinetobacter baumannii among Patients Receiving Glucocorticoid Aerosol Therapy during Invasive Mechanical Ventilation, China.
- Author
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Wenchao Zhang, Mei Yin, Wei Li, Nana Xu, Haining Lu, Weidong Qin, Hui Han, Chen Li, Dawei Wu, Hao Wang, Zhang, Wenchao, Yin, Mei, Li, Wei, Xu, Nana, Lu, Haining, Qin, Weidong, Han, Hui, Li, Chen, Wu, Dawei, and Wang, Hao
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ACINETOBACTER infections , *GRAM-negative aerobic bacteria , *RETROSPECTIVE studies , *LONGITUDINAL method , *ARTIFICIAL respiration , *INTENSIVE care units , *GLUCOCORTICOIDS - Abstract
Acinetobacter baumannii is a nosocomial pathogen associated with severe illness and death. Glucocorticoid aerosol is a common inhalation therapy in patients receiving invasive mechanical ventilation. We conducted a prospective cohort study to analyze the association between glucocorticoid aerosol therapy and A. baumannii isolation from ventilator patients in China. Of 497 enrolled patients, 262 (52.7%) received glucocorticoid aerosol, and A. baumannii was isolated from 159 (32.0%). Glucocorticoid aerosol therapy was an independent risk factor for A. baumannii isolation (hazard ratio 1.5, 95% CI 1.02-2.28; p = 0.038). Patients receiving glucocorticoid aerosol had a higher cumulative hazard for A. baumannii isolation and analysis showed that glucocorticoid aerosol therapy increased A. baumannii isolation in most subpopulations. Glucocorticoid aerosol was not a direct risk factor for 30-day mortality, but A. baumannii isolation was independently associated with 30-day mortality in ventilator patients. Physicians should consider potential A. baumannii infection when prescribing glucocorticoid aerosol therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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