20 results on '"Gabon epidemiology"'
Search Results
2. Exposure to Ebola Virus and Risk for Infection with Malaria Parasites, Rural Gabon.
- Author
-
Abbate JL, Becquart P, Leroy E, Ezenwa VO, and Roche B
- Subjects
- Adolescent, Adult, Ebolavirus immunology, Female, Gabon epidemiology, Hemorrhagic Fever, Ebola blood, Host-Parasite Interactions, Humans, Malaria, Falciparum blood, Malaria, Falciparum complications, Malaria, Falciparum mortality, Male, Middle Aged, Plasmodium falciparum immunology, Risk Factors, Rural Population, Surveys and Questionnaires, Young Adult, Ebolavirus isolation & purification, Hemorrhagic Fever, Ebola complications, Malaria, Falciparum epidemiology, Plasmodium falciparum isolation & purification
- Abstract
An association between malaria and risk for death among patients with Ebola virus disease has suggested within-host interactions between Plasmodium falciparum parasites and Ebola virus. To determine whether such an interaction might also influence the probability of acquiring either infection, we used a large snapshot surveillance study from rural Gabon to test if past exposure to Ebola virus is associated with current infection with Plasmodium spp. during nonepidemic conditions. We found a strong positive association, on population and individual levels, between seropositivity for antibodies against Ebola virus and the presence of Plasmodium parasites in the blood. According to a multiple regression model accounting for other key variables, antibodies against Ebola virus emerged as the strongest individual-level risk factor for acquiring malaria. Our results suggest that within-host interactions between malaria parasites and Ebola virus may underlie epidemiologic associations.
- Published
- 2020
- Full Text
- View/download PDF
3. VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy.
- Author
-
Fonseca AM, González R, Bardají A, Jairoce C, Rupérez M, Jiménez A, Quintó L, Cisteró P, Vala A, Sacoor C, Gupta H, Hegewisch-Taylor J, Brew J, Ndam NT, Kariuki S, López M, Dobaño C, Chitnis CE, Ouma P, Ramharter M, Abdulla S, Aponte JJ, Massougbodji A, Briand V, Mombo-Ngoma G, Desai M, Cot M, Nhacolo A, Sevene E, Macete E, Menéndez C, and Mayor A
- Subjects
- Adult, Antibodies, Protozoan immunology, Antigens, Protozoan immunology, Benin epidemiology, Female, Gabon epidemiology, Humans, Immunoglobulin G immunology, Kenya epidemiology, Malaria, Falciparum diagnosis, Malaria, Falciparum epidemiology, Malaria, Falciparum transmission, Mozambique epidemiology, Plasmodium falciparum immunology, Pregnancy, Pregnancy Complications, Parasitic blood, Pregnancy Complications, Parasitic diagnosis, Serologic Tests methods, Spain epidemiology, Tanzania epidemiology, Young Adult, Antigens, Protozoan blood, Malaria, Falciparum complications, Pregnancy Complications, Parasitic epidemiology
- Abstract
Pregnant women constitute a promising sentinel group for continuous monitoring of malaria transmission. To identify antibody signatures of recent Plasmodium falciparum exposure during pregnancy, we dissected IgG responses against VAR2CSA, the parasite antigen that mediates placental sequestration. We used a multiplex peptide-based suspension array in 2,354 samples from pregnant women from Mozambique, Benin, Kenya, Gabon, Tanzania, and Spain. Two VAR2CSA peptides of limited polymorphism were immunogenic and targeted by IgG responses readily boosted during infection and with estimated half-lives of <2 years. Seroprevalence against these peptides reflected declines and rebounds of transmission in southern Mozambique during 2004-2012, reduced exposure associated with use of preventive measures during pregnancy, and local clusters of transmission that were missed by detection of P. falciparum infections. These data suggest that VAR2CSA serology can provide a useful adjunct for the fine-scale estimation of the malaria burden among pregnant women over time and space.
- Published
- 2019
- Full Text
- View/download PDF
4. Human African Trypanosomiasis in Emigrant Returning to China from Gabon, 2017.
- Author
-
Wang X, Ruan Q, Xu B, Gu J, Qian Y, Chen M, Liu Q, Lu Q, and Zhang W
- Subjects
- China epidemiology, Drug Therapy, Combination, Eflornithine administration & dosage, Eflornithine therapeutic use, Gabon epidemiology, Humans, Nifurtimox administration & dosage, Nifurtimox therapeutic use, Trypanocidal Agents administration & dosage, Trypanocidal Agents therapeutic use, Trypanosoma brucei gambiense, Emigrants and Immigrants, Trypanosomiasis, African epidemiology, Trypanosomiasis, African parasitology
- Abstract
Human African trypanosomiasis is endemic to parts of sub-Saharan Africa and should be considered in the differential diagnosis of patients who have visited or lived in Africa. We report a 2017 case of stage 2 Trypanosoma brucei gambiense disease in an emigrant who returned to China from Gabon.
- Published
- 2018
- Full Text
- View/download PDF
5. Emergence of bla NDM-7 -Producing Enterobacteriaceae in Gabon, 2016.
- Author
-
Moussounda M, Diene SM, Dos Santos S, Goudeau A, François P, and van der Mee-Marquet N
- Subjects
- Anti-Bacterial Agents, Communicable Diseases, Emerging history, Enterobacteriaceae classification, Enterobacteriaceae Infections history, Gabon epidemiology, History, 21st Century, Humans, Microbial Sensitivity Tests, Multilocus Sequence Typing, Phylogeny, Prevalence, beta-Lactamases biosynthesis, Communicable Diseases, Emerging epidemiology, Communicable Diseases, Emerging microbiology, Enterobacteriaceae genetics, Enterobacteriaceae Infections epidemiology, Enterobacteriaceae Infections microbiology, beta-Lactamases genetics
- Abstract
Reports of carbapenemase-producing Enterobacteriaceae in Africa remain rare and assess mostly bla
OXA-48 -producing isolates from Mediterranean countries and South Africa. We identified blaNDM-7 -producing Enterobacteriaceae in Gabon in 2016. The isolates contained blaNDM-7 IncX3 plasmids that were unusual and similar to the one described in a colistin-resistant Klebsiella pneumoniae SZ04 isolate from China.- Published
- 2017
- Full Text
- View/download PDF
6. Chlamydia-Related Bacteria in Free-Living and Captive Great Apes, Gabon.
- Author
-
Klöckner A, Nagel M, Greub G, Aeby S, Hoffmann K, Liégeois F, Rouet F, De Benedetti S, Borel N, and Henrichfreise B
- Subjects
- Animals, Chlamydia genetics, Chlamydia isolation & purification, Gabon epidemiology, Molecular Typing, RNA, Ribosomal, 16S genetics, Ape Diseases epidemiology, Ape Diseases microbiology, Chlamydia classification, Chlamydia Infections veterinary, Hominidae microbiology
- Published
- 2016
- Full Text
- View/download PDF
7. Possible Role of Rickettsia felis in Acute Febrile Illness among Children in Gabon.
- Author
-
Mourembou G, Lekana-Douki JB, Mediannikov O, Nzondo SM, Kouna LC, Essone JC, Fenollar F, and Raoult D
- Subjects
- Adolescent, Child, Child, Preschool, Female, Fever epidemiology, Gabon epidemiology, Humans, Infant, Male, Rickettsia felis genetics, Fever etiology, Rickettsia felis pathogenicity
- Abstract
Rickettsia felis has been reported to be a cause of fever in sub-Saharan Africa, but this association has been poorly evaluated in Gabon. We assessed the prevalence of this bacterium among children <15 years of age in 4 areas of Gabon; the locations were in urban, semiurban, and rural areas. DNA samples from 410 febrile children and 60 afebrile children were analyzed by quantitative PCR. Overall, the prevalence of R. felis among febrile and afebrile children was 10.2% (42/410 children) and 3.3% (2/60 children), respectively. Prevalence differed among febrile children living in areas that are urban (Franceville, 1.3% [1/77]), semiurban (Koulamoutou, 2.1% [3/141]), and rural (Lastourville, 11.2% [15/134]; Fougamou, 39.7% [23/58]). Furthermore, in a rural area (Fougamou), R. felis was significantly more prevalent in febrile (39.7% [23/58]) than afebrile children (5.0% [1/20]). Additional studies are needed to better understand the pathogenic role of R. felis in this part of the world.
- Published
- 2015
- Full Text
- View/download PDF
8. Loa loa Infection in Pregnant Women, Gabon.
- Author
-
Mombo-Ngoma G, Mackanga JR, Basra A, Capan M, Manego RZ, Adegnika AA, Lötsch F, Yazdanbakhsh M, González R, Menendez C, Mabika B, Matsiegui PB, Kremsner PG, and Ramharter M
- Subjects
- Animals, Female, Gabon epidemiology, Pregnancy, Loa isolation & purification, Loiasis epidemiology, Loiasis parasitology, Pregnancy Complications, Parasitic epidemiology, Pregnancy Complications, Parasitic parasitology
- Published
- 2015
- Full Text
- View/download PDF
9. Clinical, environmental, and serologic surveillance studies of melioidosis in Gabon, 2012-2013.
- Author
-
Wiersinga WJ, Birnie E, Weehuizen TA, Alabi AS, Huson MA, Huis in 't Veld RA, Mabala HK, Adzoda GK, Raczynski-Henk Y, Esen M, Lell B, Kremsner PG, Visser CE, Wuthiekanun V, Peacock SJ, van der Ende A, Limmathurotsakul D, and Grobusch MP
- Subjects
- Adolescent, Antibodies, Bacterial blood, Burkholderia pseudomallei genetics, Burkholderia pseudomallei immunology, Child, Community-Acquired Infections blood, Community-Acquired Infections diagnosis, Community-Acquired Infections epidemiology, Environmental Monitoring, Epidemiological Monitoring, Fatal Outcome, Female, Gabon epidemiology, Humans, Male, Mass Screening, Melioidosis diagnosis, Melioidosis microbiology, Middle Aged, Phylogeny, Prevalence, Prospective Studies, Young Adult, Burkholderia pseudomallei isolation & purification, Melioidosis epidemiology, Soil Microbiology
- Abstract
Burkholderia pseudomallei, an environmental gram-negative bacillus, is the causative agent of melioidosis and a bio-threat agent. Reports of B. pseudomallei isolation from soil and animals in East and West Africa suggest that melioidosis might be more widely distributed than previously thought. Because it has been found in equatorial areas with tropical climates, we hypothesized that B. pseudomallei could exist in Gabon. During 2012-2013, we conducted a seroprevalance study in which we set up microbiology facilities at a large clinical referral center and prospectively screened all febrile patients by conducting blood cultures and testing for B. pseudomallei and related species; we also determined whether B. pseudomallei could be isolated from soil. We discovered a novel B. pseudomallei sequence type that caused lethal septic shock and identified B. pseudomallei and B. thailandensis in the environment. Our data suggest that melioidosis is emerging in Central Africa but is unrecognized because of the lack of diagnostic microbiology facilities.
- Published
- 2015
- Full Text
- View/download PDF
10. Early introduction and delayed dissemination of pandemic influenza, Gabon.
- Author
-
Lekana-Douki SE, Mouinga-Ondémé A, Nkoghe D, Drosten C, Drexler JF, Kazanji M, and Leroy EM
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Epidemiological Monitoring, Female, Gabon epidemiology, Humans, Infant, Influenza, Human virology, Male, Middle Aged, Retrospective Studies, Urban Population, Influenza A Virus, H1N1 Subtype isolation & purification, Influenza, Human epidemiology, Pandemics
- Abstract
Active surveillance in health care centers in Gabon during 2009-2011 detected 72 clinical cases of pandemic (H1N1) 2009 (pH1N1). We found that pH1N1 virus was introduced in mid-2009 but spread throughout the country in 2010. Thus, Gabon was also affected by pH1N1.
- Published
- 2013
- Full Text
- View/download PDF
11. Buruli ulcer in Gabon, 2001-2010.
- Author
-
Ngoa UA, Adzoda GK, Louis BM, Adegnika AA, and Lell B
- Subjects
- Adolescent, Adult, Aged, Buruli Ulcer economics, Buruli Ulcer microbiology, Buruli Ulcer pathology, Child, Child, Preschool, Female, Gabon epidemiology, Hospitalization statistics & numerical data, Humans, Male, Middle Aged, Mycobacterium ulcerans, Prevalence, Young Adult, Buruli Ulcer epidemiology
- Published
- 2012
- Full Text
- View/download PDF
12. Urban transmission of human African trypanosomiasis, Gabon.
- Author
-
Simon F, Mura M, Pagès F, Morand G, Truc P, Louis F, and Gautret P
- Subjects
- Gabon epidemiology, Humans, Male, Middle Aged, Pentamidine therapeutic use, Trypanocidal Agents therapeutic use, Trypanosomiasis, African drug therapy, Trypanosomiasis, African epidemiology, Urban Population, Trypanosomiasis, African transmission
- Published
- 2012
- Full Text
- View/download PDF
13. Risk for human African trypanosomiasis, Central Africa, 2000-2009.
- Author
-
Simarro PP, Cecchi G, Franco JR, Paone M, Fèvre EM, Diarra A, Postigo JA, Mattioli RC, and Jannin JG
- Subjects
- Africa, Central epidemiology, Cameroon epidemiology, Central African Republic epidemiology, Chad epidemiology, Communicable Diseases, Emerging epidemiology, Congo epidemiology, Equatorial Guinea epidemiology, Gabon epidemiology, Humans, Population Surveillance, Risk Factors, World Health Organization, Trypanosomiasis, African epidemiology
- Abstract
Comprehensive georeference records for human African trypanosomiasis in Cameroon, Central African Republic, Chad, Congo, Equatorial Guinea, and Gabon were combined with human population layers to estimate a kernel-smoothed relative risk function. Five risk categories were mapped, and ≈3.5 million persons were estimated to be at risk for this disease.
- Published
- 2011
- Full Text
- View/download PDF
14. No evidence of dengue virus circulation in rural Gabon.
- Author
-
Pourrut X, Nkoghé D, Gonzalez JP, and Leroy E
- Subjects
- Animals, Animals, Wild virology, Dengue diagnosis, Dengue veterinary, Dengue virology, Enzyme-Linked Immunosorbent Assay, Gabon epidemiology, Haplorhini virology, Humans, Immunoglobulin G blood, Immunoglobulin M blood, Monkey Diseases diagnosis, Monkey Diseases virology, Pets virology, Prevalence, Antibodies, Viral blood, Dengue epidemiology, Dengue Virus immunology, Monkey Diseases epidemiology, Rural Population statistics & numerical data
- Published
- 2011
- Full Text
- View/download PDF
15. Immunoglobulin G in Ebola outbreak survivors, Gabon.
- Author
-
Wauquier N, Becquart P, Gasquet C, and Leroy EM
- Subjects
- Animals, Child, Gabon epidemiology, Hemorrhagic Fever, Ebola immunology, Hemorrhagic Fever, Ebola mortality, Hemorrhagic Fever, Ebola transmission, Humans, Pan troglodytes virology, Seroepidemiologic Studies, Survivors, Disease Outbreaks statistics & numerical data, Hemorrhagic Fever, Ebola epidemiology, Immunoglobulin G blood
- Published
- 2009
- Full Text
- View/download PDF
16. Concurrent chikungunya and dengue virus infections during simultaneous outbreaks, Gabon, 2007.
- Author
-
Leroy EM, Nkoghe D, Ollomo B, Nze-Nkogue C, Becquart P, Grard G, Pourrut X, Charrel R, Moureau G, Ndjoyi-Mbiguino A, and De-Lamballerie X
- Subjects
- Aedes virology, Alphavirus Infections transmission, Animals, Communicable Diseases, Emerging transmission, Communicable Diseases, Emerging virology, Dengue transmission, Dengue virology, Dengue Virus classification, Dengue Virus genetics, Dengue Virus isolation & purification, Gabon epidemiology, Genome, Viral, Humans, Insect Vectors virology, Phylogeny, Alphavirus Infections complications, Alphavirus Infections epidemiology, Chikungunya virus, Communicable Diseases, Emerging complications, Communicable Diseases, Emerging epidemiology, Dengue complications, Dengue epidemiology, Disease Outbreaks
- Abstract
An outbreak of febrile illness occurred in Gabon in 2007, with 20,000 suspected cases. Chikungunya or dengue-2 virus infections were identified in 321 patients; 8 patients had documented co-infections. Aedes albopictus was identified as the principal vector for the transmission of both viruses.
- Published
- 2009
- Full Text
- View/download PDF
17. Ebola virus antibody prevalence in dogs and human risk.
- Author
-
Allela L, Boury O, Pouillot R, Délicat A, Yaba P, Kumulungui B, Rouquet P, Gonzalez JP, and Leroy EM
- Subjects
- Animals, Disease Outbreaks, Gabon epidemiology, Hemorrhagic Fever, Ebola epidemiology, Humans, Prevalence, Antibodies, Viral blood, Disease Reservoirs, Dogs virology, Ebolavirus immunology
- Abstract
During the 2001-2002 outbreak in Gabon, we observed that several dogs were highly exposed to Ebola virus by eating infected dead animals. To examine whether these animals became infected with Ebola virus, we sampled 439 dogs and screened them by Ebola virus-specific immunoglobulin (Ig) G assay, antigen detection, and viral polymerase chain reaction amplification. Seven (8.9%) of 79 samples from the 2 main towns, 15 (15.2%) of 99 samples from Mekambo, and 40 (25.2%) of 159 samples from villages in the Ebola virus-epidemic area had detectable Ebola virus-IgG, compared to only 2 (2%) of 102 samples from France. Among dogs from villages with both infected animal carcasses and human cases, seroprevalence was 31.8%. A significant positive direct association existed between seroprevalence and the distances to the Ebola virus-epidemic area. This study suggests that dogs can be infected by Ebola virus and that the putative infection is asymptomatic.
- Published
- 2005
- Full Text
- View/download PDF
18. Wild animal mortality monitoring and human Ebola outbreaks, Gabon and Republic of Congo, 2001-2003.
- Author
-
Rouquet P, Froment JM, Bermejo M, Kilbourn A, Karesh W, Reed P, Kumulungui B, Yaba P, Délicat A, Rollin PE, and Leroy EM
- Subjects
- Animals, Antigens, Viral analysis, Ape Diseases mortality, DNA, Viral chemistry, DNA, Viral genetics, Democratic Republic of the Congo epidemiology, Ebolavirus genetics, Gabon epidemiology, Hemorrhagic Fever, Ebola epidemiology, Hemorrhagic Fever, Ebola genetics, Hemorrhagic Fever, Ebola mortality, Humans, Immunohistochemistry veterinary, Polymerase Chain Reaction veterinary, Zoonoses epidemiology, Ape Diseases virology, Disease Outbreaks veterinary, Ebolavirus isolation & purification, Gorilla gorilla, Hemorrhagic Fever, Ebola transmission, Hemorrhagic Fever, Ebola veterinary, Pan troglodytes, Zoonoses virology
- Abstract
All human Ebola virus outbreaks during 2001-2003 in the forest zone between Gabon and Republic of Congo resulted from handling infected wild animal carcasses. After the first outbreak, we created an Animal Mortality Monitoring Network in collaboration with the Gabonese and Congolese Ministries of Forestry and Environment and wildlife organizations (Wildlife Conservation Society and Programme de Conservation et Utilisation Rationnelle des Ecosystemes Forestiers en Afrique Centrale) to predict and possibly prevent human Ebola outbreaks. Since August 2001, 98 wild animal carcasses have been recovered by the network, including 65 great apes. Analysis of 21 carcasses found that 10 gorillas, 3 chimpanzees, and 1 duiker tested positive for Ebola virus. Wild animal outbreaks began before each of the 5 human Ebola outbreaks. Twice we alerted the health authorities to an imminent risk for human outbreaks, weeks before they occurred.
- Published
- 2005
- Full Text
- View/download PDF
19. Bartonella clarridgeiae and B. henselae in dogs, Gabon.
- Author
-
Gundi VA, Bourry O, Davous B, Raoult D, and La Scola B
- Subjects
- Animals, Bartonella classification, Bartonella isolation & purification, Bartonella Infections epidemiology, Bartonella henselae isolation & purification, Dog Diseases microbiology, Dogs, Female, Gabon epidemiology, Male, Bartonella Infections veterinary, Dog Diseases epidemiology
- Published
- 2004
- Full Text
- View/download PDF
20. Isolation and phylogenetic characterization of Ebola viruses causing different outbreaks in Gabon.
- Author
-
Georges-Courbot MC, Sanchez A, Lu CY, Baize S, Leroy E, Lansout-Soukate J, Tévi-Bénissan C, Georges AJ, Trappier SG, Zaki SR, Swanepoel R, Leman PA, Rollin PE, Peters CJ, Nichol ST, and Ksiazek TG
- Subjects
- Animals, Ape Diseases pathology, Ape Diseases virology, Ebolavirus pathogenicity, Gabon epidemiology, Genes, Viral, Genetic Variation, Glycoproteins genetics, Hemorrhagic Fever, Ebola veterinary, Humans, Pan troglodytes, RNA, Viral genetics, RNA, Viral isolation & purification, Viral Proteins genetics, Viral Structural Proteins genetics, Disease Outbreaks, Ebolavirus genetics, Ebolavirus isolation & purification, Hemorrhagic Fever, Ebola epidemiology, Hemorrhagic Fever, Ebola virology, Phylogeny
- Abstract
Three outbreaks of Ebola hemorrhagic fever have recently occurred in Gabon. Virus has been isolated from clinical materials from all three outbreaks, and nucleotide sequence analysis of the glycoprotein gene of the isolates and virus present in clinical samples has been carried out. These data indicate that each of the three outbreaks should be considered an independent emergence of a different Ebola virus of the Zaire subtype. As in earlier Ebola virus outbreaks, no genetic variability was detected between virus samples taken during an individual outbreak.
- Published
- 1997
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.