1. Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season.
- Author
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Hageman JC, Uyeki TM, Francis JS, Jernigan DB, Wheeler JG, Bridges CB, Barenkamp SJ, Sievert DM, Srinivasan A, Doherty MC, McDougal LK, Killgore GE, Lopatin UA, Coffman R, MacDonald JK, McAllister SK, Fosheim GE, Patel JB, and McDonald LC
- Subjects
- Adolescent, Adult, Child, Child, Preschool, Community-Acquired Infections virology, DNA, Bacterial chemistry, DNA, Bacterial genetics, Electrophoresis, Gel, Pulsed-Field, Female, Genotype, Humans, Infant, Influenza, Human immunology, Influenza, Human virology, Male, Methicillin Resistance, Microbial Sensitivity Tests, Middle Aged, Pneumonia, Bacterial virology, Staphylococcus aureus drug effects, Community-Acquired Infections microbiology, Influenza, Human microbiology, Orthomyxoviridae, Pneumonia, Bacterial microbiology, Staphylococcal Infections microbiology, Staphylococcal Infections virology, Staphylococcus aureus isolation & purification
- Abstract
During the 2003-04 influenza season, 17 cases of Staphylococcus aureus community-acquired pneumonia (CAP) were reported from 9 states; 15 (88%) were associated with methicillin-resistant S. aureus (MRSA). The median age of patients was 21 years; 5 (29%) had underlying diseases, and 4 (24%) had risk factors for MRSA. Twelve (71%) had laboratory evidence of influenza virus infection. All but 1 patient, who died on arrival, were hospitalized. Death occurred in 5 (4 with MRSA). S. aureus isolates were available from 13 (76%) patients (11 MRSA). Toxin genes were detected in all isolates; 11 (85%) had only genes for Panton-Valentine leukocidin. All isolates had community-associated pulsed-field gel electrophoresis patterns; all MRSA isolates had the staphylococcal cassette chromosome mec type IVa. In communities with a high prevalence of MRSA, empiric therapy of severe CAP during periods of high influenza activity should include consideration for MRSA.
- Published
- 2006
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