1. Case Definition of Chronic Pulmonary Aspergillosis in Resource-Constrained Settings - Volume 24, Number 8—August 2018 - Emerging Infectious Diseases journal - CDC
- Author
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Denning, David W, Page, Iain D, Chakaya, Jeremiah, Jabeen, Kauser, Jude, Cecilia M, Cornet, Muriel, Alastruey-Izquierdo, Ana, Bongomin, Felix, Bowyer, Paul, Chakrabarti, Arunaloke, Gago, Sara, Guto, John, Hochhegger, Bruno, Hoenigl, Martin, Irfan, Muhammad, Irurhe, Nicholas, Izumikawa, Koichi, Kirenga, Bruce, Manduku, Veronica, Moazam, Samihah, Oladele, Rita O, Richardson, Malcolm D, Tudela, Juan Luis Rodriguez, Rozaliyani, Anna, Salzer, Helmut JF, Sawyer, Richard, Simukulwa, Nasilele F, Skrahina, Alena, Sriruttan, Charlotte, Setianingrum, Findra, Wilopo, Bayu AP, Cole, Donald C, and Getahun, Haileyesus
- Subjects
Tuberculosis ,Biodefense ,Lung ,Emerging Infectious Diseases ,Infectious Diseases ,Vaccine Related ,Prevention ,Rare Diseases ,Infection ,Good Health and Well Being ,Chronic Disease ,Developing Countries ,Humans ,Practice Guidelines as Topic ,Pulmonary Aspergillosis ,Socioeconomic Factors ,Aspergillus ,antibody ,aspergilloma ,developing countries ,fungi ,imaging ,resource-constrained settings ,tuberculosis and other mycobacteria ,Clinical Sciences ,Medical Microbiology ,Public Health and Health Services ,Microbiology - Abstract
Chronic pulmonary aspergillosis (CPA) is a recognized complication of pulmonary tuberculosis (TB). In 2015, the World Health Organization reported 2.2 million new cases of nonbacteriologically confirmed pulmonary TB; some of these patients probably had undiagnosed CPA. In October 2016, the Global Action Fund for Fungal Infections convened an international expert panel to develop a case definition of CPA for resource-constrained settings. This panel defined CPA as illness for >3 months and all of the following: 1) weight loss, persistent cough, and/or hemoptysis; 2) chest images showing progressive cavitary infiltrates and/or a fungal ball and/or pericavitary fibrosis or infiltrates or pleural thickening; and 3) a positive Aspergillus IgG assay result or other evidence of Aspergillus infection. The proposed definition will facilitate advancements in research, practice, and policy in lower- and middle-income countries as well as in resource-constrained settings.
- Published
- 2018