1. Haptoglobin phenotype in women with preeclampsia
- Author
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Hoda Awad, Rami N. Sammour, Rachel Miller-Lotan, Andrew P. Levy, Farid Nakhoul, Ron Gonen, Gonen Ohel, and Nakhoul Nakhoul
- Subjects
Adult ,Endocrinology, Diabetes and Metabolism ,Disease ,medicine.disease_cause ,Preeclampsia ,Young Adult ,Endocrinology ,Pre-Eclampsia ,Pregnancy ,Risk Factors ,Diabetes mellitus ,Placenta ,polycyclic compounds ,medicine ,Prevalence ,Humans ,skin and connective tissue diseases ,biology ,Haptoglobins ,business.industry ,Haptoglobin ,food and beverages ,Placentation ,medicine.disease ,Phenotype ,Oxidative Stress ,medicine.anatomical_structure ,Case-Control Studies ,Immunology ,biology.protein ,Electrophoresis, Polyacrylamide Gel ,Female ,business ,Oxidative stress - Abstract
In pre-eclampsia, poor placentation causes both oxidative and endoplasmic reticulum stress of the placenta. The anti-oxidative protein Haptoglobin has three phenotypes: 1-1, 1-2, and 2-2. Haptoglobin 1-1 is a more potent antioxidant. Our objective was to determine whether haptoglobin 1-1 was less common in women with preeclampsia which is a disease with an oxidatives-stress component, compared to the healthy population. Haptoglobin phenotype was compared in 240 healthy and 120 preeclamptic gravida in a case–control study. Statistical analysis was performed using Chi square test. The prevalence of haptoglobin 1-1 was 13% among healthy women and 6% among preeclamptic women (P = 0.049). Secondary analysis was also performed. The prevalence of haptoglobin 1-1 is higher in healthy compared to preeclamptic subjects, a finding compatible with a protective role. Haptoglobin 1-1 might have a protective role in preeclampsia. Further work is needed with more Hp 1-1 subjects before we can conclude on the possible use of Haptoglobin phenotype to assess the risk of preeclampsia.
- Published
- 2010