1. [Estimated glucose disposal rate in patients under 18 years of age with type 1 diabetes mellitus and overweight or obesity].
- Author
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Palomo Atance E, Ballester Herrera MJ, Giralt Muiña P, Ruiz Cano R, León Martín A, and Giralt Muiña J
- Subjects
- Adolescent, Anthropometry, Blood Pressure, Child, Child, Preschool, Cross-Sectional Studies, Diabetes Mellitus, Type 1 complications, Diabetes Mellitus, Type 1 drug therapy, Female, Glycated Hemoglobin analysis, Humans, Hypertension complications, Insulin administration & dosage, Insulin classification, Insulin therapeutic use, Insulin Resistance, Lipids blood, Lipoproteins blood, Male, Metabolic Syndrome metabolism, Obesity complications, Obesity metabolism, Overweight complications, Prospective Studies, Sampling Studies, Waist-Hip Ratio, Diabetes Mellitus, Type 1 metabolism, Glucose metabolism, Overweight metabolism
- Abstract
Objective: To assess the estimated glucose disposal rate (eGDR), insulin dose, and lipoprotein profile in children with type 1 diabetes mellitus (T1DM) and overweight or obesity as compared to children with T1DM and normal weight., Methods: A total of 115 patients (aged 5-16 years) with T1DM on intensive insulin therapy were recruited. The following parameters were measured: weight, height, body mass index, waist and hip circumference, insulin dose, eGDR, glycosylated hemoglobin, blood pressure, and lipoprotein profile. Results were stratified by sex and age., Results: No significant differences were found in eGDR between children with normal weight, overweight, and obesity. However, obese children older than 11 years had lower eGDR values (9.3±1.3 vs 10.1±0.8 mg kg(-1)min(-1); p<0.01). Insulin dose was higher in overweight and obese children, especially in IU/m2/day (37.7 vs 36.1 vs. 29.4 respectively; p<0.01). Obese children had higher low-density lipoprotein cholesterol levels than children with overweight and normal weight (106.5 vs 91.7 vs 91.5mg/dL respectively; p<0.01). No correlation was found between waist circumference and the different markers of insulin resistance., Conclusions: Values of eGDR values were lower in obese children with T1DM older than 11 years, and this may therefore be considered a marker of insulin resistance. Insulin dose was higher in diabetic patients with overweight or obesity, specially in IU/m2/day. Obese children with T1DM had a lipoprotein profile of cardiovascular risk., (Copyright © 2012 SEEN. Published by Elsevier Espana. All rights reserved.)
- Published
- 2013
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