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Last year we reported observations on the treatment of undescended testes with an anterior pituitary-like principle.2 We were able to produce descent in only 19 per cent of the cases, in contrast to an average of 70 per cent of successful results of other workers. However, we did observe that this material, by stimulating genital growth, seemed to make operative procedures less difficult, and therefore appeared to be valuable preceding surgery, whether it produced descent or not. These observations have now been extended and confirmed. Our incidence of successful results has remained about the same, being now 22 per cent instead of 19 per cent. However, an important development has taken place. Premature puberty has been produced in young boys by the prolonged administration of this material. This marked stimulation of genital growth has led to the application of the APL principle to the treatment of hypogenitalism in the male with very satisfactory results.

In recent years numerous reports concerning the treatment of cryptorchidism and hypogenitalism with the use of various gonadotropic hormones have appeared in the literature. Most reports have dealt with the use of gonadotropic hormones either from pregnancy urine, placenta, or beef pituitary and have been used chiefly for the treatment of the afore-mentioned conditions in young males. Recently, Thompson (1) and his associates have reported on the production of precocious puberty and hypertrophy of the genitalia in males receiving gonadotropic hormone for the treatment of cryptorchidism. In their cases, however, these conditions were produced only after large doses of hormone had been administered over long periods. In our own experience (2) covering a period of over 6 years, during which time we have treated a considerable number of males with hypogenitalism, some with and some without cryptorchidism, we have not observed the development of premature or precocious puberty or abnormal hypertrophy of the ge...