1. Reassessment of the predictive value of the Forrest classification for peptic ulcer rebleeding and mortality: can classification be simplified?
- Author
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Bert C. Baak, Koen Kessels, Albert J. Bredenoord, Niels G. Venneman, Janne de Rooij, Robin Timmer, J. H. Bosman, Martijn G.H. van Oijen, Robert Verburg, Peter D. Siersema, Maarten Hemmink, Wouter L. Curvers, Reinoud R. Vermeijden, Marieke Pennings, Nicolette L. de Groot, Rachel L. A. van Eijk, Wouter L. Hazen, Koen van Hee, Bas L. Weusten, Niels van Lelyveld, Bob C. H. Scheffer, Laetitia R H de Wijkerslooth, Ruby Meiland, Oncology, Other departments, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA -Cancer Center Amsterdam, and Gastroenterology and Hepatology
- Subjects
Male ,medicine.medical_specialty ,Peptic ,Subgroup analysis ,Gastroenterology ,Risk Assessment ,Predictive Value of Tests ,Recurrence ,Internal medicine ,medicine ,Humans ,Prospective Studies ,Stomach Ulcer ,Prospective cohort study ,Aged ,Aged, 80 and over ,Receiver operating characteristic ,business.industry ,Mortality rate ,Hemostasis, Endoscopic ,Odds ratio ,Middle Aged ,digestive system diseases ,Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11] ,Peptic Ulcer Hemorrhage ,Forrest classification ,ROC Curve ,Predictive value of tests ,Area Under Curve ,Duodenal Ulcer ,Female ,business - Abstract
Item does not contain fulltext BACKGROUND AND STUDY AIMS: This study aimed to reassess whether the Forrest classification is still useful for the prediction of rebleeding and mortality in peptic ulcer bleedings and, based on this, whether the classification could be simplified. PATIENTS AND METHODS: Prospective registry data on peptic ulcer bleedings were collected and categorized according to the Forrest classification. The primary outcomes were 30-day rebleeding and all-cause mortality rates. Receiver operating characteristic curves were used to test whether simplification of the Forrest classification into high risk (Forrest Ia), increased risk (Forrest Ib-IIc), and low risk (Forrest III) classes could be an alternative to the original classification. RESULTS: In total, 397 patients were included, with 18 bleedings (4.5%) being classified as Forrest Ia, 73 (18.4%) as Forrest Ib, 86 (21.7%) as Forrest IIa, 32 (8.1%) as Forrest IIb, 59 (14.9%) as Forrest IIc, and 129 (32.5%) as Forrest III. Rebleeding occurred in 74 patients (18.6%). Rebleeding rates were highest in Forrest Ia peptic ulcers (59%). The odds ratios for rebleeding among Forrest Ib-IIc ulcers were similar. In subgroup analysis, predicting rebleeding using the Forrest classification was more reliable for gastric ulcers than for duodenal ulcers. The simplified Forrest classification had similar test characteristics to the original Forrest classification. CONCLUSION: The Forrest classification still has predictive value for rebleeding of peptic ulcers, especially for gastric ulcers; however, it does not predict mortality. Based on these results, a simplified Forrest classification is proposed. However, further studies are needed to validate these findings.
- Published
- 2013