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Mining-induced hydromechanical behavior of sandstone is critical to mining safety and disaster prevention. To investigate the evolution behavior of the mechanical and permeability properties of sandstone, mining-induced stress was imitated by increasing axial stress and decreasing confining stress, and a set of hydromechanical experiments were further performed, incorporating the effect of in situ stress, pore pressure, and mining stress. The results show the similar variation tendencies of the deformation and permeability of sandstone under different loading paths of in situ stress and pore pressure. Most sandstone samples maintain a compression state for the peak stress condition. The failure mode evolved from shear failure to shear–tension failure with the increase in in situ stress. The stress-relief effect significantly effects the permeability, since the permeability of sandstone increases exponentially with decreasing effective confining stress. The growth rate of permeability in Stage II is significantly greater than that in Stage I. One order of magnitude of permeability was presented at the peak stress situation. A fitting exponential model based on the alteration of effective confining stress was proposed to describe the permeability evolution dominated by the stress-relief effect, and the discovered permeability model can accurately describe the experimental results. The research results provide significant guidance for understanding the hydromechanical behavior and water hazard prevention for underground coal mines. [ABSTRACT FROM AUTHOR]