The load following of nuclear power plants (NPPs) has been a contentious issue in the control field. In this paper, we propose a chattering-free higher order sliding mode control scheme with a high-gain observer for the load following of a pressurized water reactor (PWR) in the presence of lumped disturbances owing to model uncertainties and external disturbances. The mathematical model of the PWR system is first set up in the form of an affine nonlinear equation. Subsequently, a high-gain observer, which achieves accurate estimations of the unmeasured state and lumped disturbances, is designed. Based on the outputs of the high-gain observer, we develop a chattering-free higher order sliding mode controller to improve the load-following performance while dealing with lumped disturbances and estimation errors of the high-gain observer. In contrast to some previous sliding mode controllers for the load following of NPPs, the proposed controller is completely free from chattering effects because the control input is obtained after integration. The asymptotic stability of the overall control scheme is demonstrated by combining the Lyapunov stability theory with backstepping technology. Finally, the simulation results reveal that the maximum absolute power error is less than 1 × 10 4 W with the proposed control scheme, 5 × 10 5 W with a PID controller, and 4 × 10 5 W with a conventional sliding mode controller. In addition, in contrast to the conventional sliding mode controller, the proposed control scheme produces smooth control input without the chattering phenomenon. Thus, the proposed chattering-free higher order sliding mode control scheme with a high-gain observer provides smoother control input, higher load-following accuracy, and stronger robustness against lumped disturbances than the PID controller and the conventional sliding mode controller.