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• Ventilation rate and arrangement are crucial to prevent airborne disease in healthcare facilities. • Local ventilation is practical for supply fresh air and diluting contaminants in high-risk areas. • Microplastics emerged as potential virus carriers in indoor environments, warrant further investigations. The prevalence and transmission of airborne infections pose significant challenges to public health, leading to consequential negative impacts. Ventilation strategies are crucial in mitigating airborne infections in healthcare settings, preventing the spread of infectious diseases, thus protecting patients and healthcare workers. While individual studies have explored various aspects of ventilation in healthcare settings, a synthesized overview of the current state of knowledge is lacking. Therefore, this study attempts to bridge the gap by conducting a review and bibliometric analysis based on 198 papers published within the recent decades (1993–2022). The findings will provide a holistic understanding on the innovative interventions and identify areas for future research, thereby contributing to the development of effective guidelines for controlling airborne infections. The co-authorship analysis revealed that China emerged as the main contributor in the current research field due to the keen interest of researchers and the substantial financial support provided by funding agencies. The keyword co-occurrence analysis identified three primary research hotspots within the field, (i) the optimized ventilation strategies for combating airborne infection, (ii) the transition towards the application of computational fluid dynamics (CFD) in analyzing airflow patterns, and, (iii) the characteristics of airborne particles and their impact on infection transmission. The present review highlights the significance of local ventilation as an additional measure to the main ventilation system for enhanced dilution of contaminants in high-risk areas. The transition towards dynamic airflow analysis considered human movement's effect, allowing for more precise assessments and tailored ventilation strategies optimization. The review also underscores the emerging concern of microplastic as an indoor contaminant with potential implications as a virus carrier, emphasizing further research on its behavior and impact on airborne infection transmission. [ABSTRACT FROM AUTHOR]