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• A methodology to assess energy flexibility of building clusters in a GIS framework. • Building clusters become energy prosumer by deep renovation and renewable energies. • It aims to integrate a wider spatial decision tool for environmental public policy. • Comfort thermal indexes quantify energy flexibility to measure peak load reduction. • Cluster design approach may help reduce investment costs and reach cost optimality. Natural resource depletion, global warming and pollution pose substantial threats in prioritizing environmental policy, both for private organizations and for governments. Half the EU building stock is prior to energy efficiency standards, thus making it an urgent challenge for the EU to aim at decarbonized cities by 2050. Urban energy retrofitting at cluster level represents a major opportunity, as its current rate is lower than an annual 1%, 3% being the EU desirable rate. This paper presents a bottom-up methodology to assess energy flexibility of building clusters within a Geographic Information System (GIS) framework, applied on a district scale. Energy performance certificates and GIS-based data permit diagnosis and neighborhood selection. The methodology evaluates building cluster energy flexibility via energy demand reduction and PV production. The results show the building cluster hourly load profile for heating and cooling, and thermal comfort indexes. It is expected that this GIS-based methodology will become part of a wider spatial decision support tool for environmental public policies contributing to building stock transformation, from energy consumer to prosumer through deep renovation and renewable energy use. Finally, this methodology is adaptable to other climates, particularly within Spain. [ABSTRACT FROM AUTHOR]

• Listed dwellings of southern Spain were monitored in winter to evaluate IEQ and EP. • Lengthy high rates of IRH were observed. • High levels of CO 2 concentration were recorded in bedrooms at night. • Thermal comfort is only achieved through a constant use of the heating systems. • Heat losses are entirely building-driven. Although European heritage buildings are excluded from energy efficiency targets, it would be beneficial to include the largest group, that of listed housing, in energy retrofit plans, in order to encourage its occupation and contributing to the sustainable maintenance of historic cities. This requires reliable experimental studies, which have been rare so far, in order to establish energy rehabilitation plans that do not jeopardize the conservation of their values. This paper aims to contribute to addressing this gap. It evaluates the energy performance and indoor environmental quality of dwellings within listed buildings of the conservation area of Seville, Spain, in the Mediterranean climate zone, under actual winter use and occupation conditions. An experimental campaign was conducted, generating energy models and measuring rates of indoor air temperature to validate them. The findings highlight important health and environmental issues: despite the mild winters of southern Spain, intensive use of the heating system is needed to maintain thermal comfort indoors, increasing polluting emissions; CO 2 concentration in bedrooms is usually excessive overnight and, regularly, indoor relative humidity remains too high; heat losses depend entirely on the physical condition of the constructive elements (walls, roofs, air leakage and glazing) which occupants cannot easily improve. [ABSTRACT FROM AUTHOR]