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Highlights • Development of a heat exchanger semi-empirical model accounting for frost formation. • Experimental validation of the HX model in partially frost regime. • Frost control strategies numerically implemented and compared. • Strategies lead to trade-offs between ventilation quality and energy consumption. Abstract This paper tackles the issue of frost formation in air-to-air heat recovery devices dedicated to single room ventilation by means of both numerical simulations and experimental approaches. In such heat exchangers, it is commonly known that the formation of a frost layer on the surface generates an additional thermal resistance and a flow section reduction, which leads to an overall degradation of the overall unit performance. This paper proposes a three-zone model, considering a dry, a wet and a frost zone, by determining the location of moving boundaries. Each zone is handled independently and the relative proportion of each zone is determined by means of the exchanger wall temperature. Besides this frost model, a defrost model is also envisaged. Once validated with experimental data collected on a U-flow-type heat exchanger, the developed model is used to implement different strategies to reduce or prevent frost formation in the exchanger. Based on three different criteria, these strategies are compared with each other to evaluate their benefits and drawbacks. The criteria give information on the energy efficiency of the ventilation, on the air renewal quality and on the pressure balance between the inside and the outside of the building. [ABSTRACT FROM AUTHOR]