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Occupants account for a significant impact on building performance through their interactions with zone level building components. Empirically-derived occupant models, despite their potential to represent occupants’ impact in building performance simulation (BPS), have minimal penetration in design and code compliance processes. Instead, occupants are represented with static schedules or simple deterministic triggers. The objective of this paper is to better understand the influence of assumptions made in representing occupant interactions with building components over a BPS model's energy use and comfort predictions, as well as their ability to promote better design decisions. To this end, the energy and daylight performance of a generic perimeter office space in Ottawa, Canada were evaluated using a set of comprehensive performance metrics. Results indicate that representing dynamic occupant–building interactions lead to different energy predictions from the static schedules. The maximum difference in the total electricity use was for window-to-wall area ratios (WWR) of 20%, which was about 30% higher with the stochastic cases than the blind-open static cases. WWR 60% and 40% generally yielded the lowest lighting electricity use with the static and stochastic cases, respectively. This paper emphasizes the importance of incorporating empirically-derived dynamic occupant models for simulation-aided design and code compliance. [ABSTRACT FROM AUTHOR]