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• POE was carried out to compare the design target and operational effect after use. • A Large Irregular Green Commercial Building was chosen for in-depth analysis. • We recommend the building energy saving and carbon emission reduction strategy. Commercial buildings, especially large irregular commercial buildings with complex space and dense occupation, have high energy consumption and carbon emissions. Moreover, the actual operating performance differs significantly from its design, in terms of energy conservation and carbon emissions. This study selected an irregular large-scale green commercial building in Dalian, a coastal city in the cold zone of China. The running energy consumption and indoor physical environment were investigated and analyzed, and a satisfaction survey was conducted using the Post-occupancy evaluation (POE) methods. The promotion strategies of holistic design were proposed by comparing the operational building performance with the design target. The research shows that the energy consumption of the building was 68.02 kWh/m2, which failed to meet the standard requirements. The carbon emission was 74.76 kgCO 2 /m2. Less than 10 % of humidity in summer fell in the expected range, and the lowest value of PM 2.5 concentration in winter was 28.3 %. The score of indoor environmental quality and service satisfaction was low. This paper identifies the problems and analyzes the differences between the operation stage and design phase. It provides recommendations and guidelines for optimizing the carbon emission and indoor environment based on the performance improvement of building operational conditions. [ABSTRACT FROM AUTHOR]