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•Neuroretinitis is unilateral optic nerve head edema followed 2-4 weeks later by development of macular star.•Typically, severe optic nerve head edema is out of keeping with relatively preserved visual function.•As the site of pathology are leaky capillaries on optic nerve head and not optic nerve axons, RAPD is mild or not present.•Most cases are either idiopathic or secondary to specific infectious etiologies.•Patients with neuroretinitis are not at risk of developing multiple sclerosis and do not require neuro-imaging in most cases., Competing Interests: The authors declare that they have no conflict of interest., (© 2020 Published by Elsevier B.V.)