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This paper investigates the underlying driving force in strategic decision-making. From a conceptual standpoint, few studies empirically studied the decision-maker's intrinsic state composed of entropy and uncertainty. This study examines a mutual information theory approach integrated into a state of qualia complexity that minimizes exclusion and maximizes the interactions of the information system and its dynamic environment via logical metonymy, illusion, and epigenetics. The article questions whether decision-makers at all levels of the organization are responding from the consciousness of an objective quale from a more subjective qualia awareness in the narrow-sense perspective of individual instances of their conscious experience. To quantify this research question, we explore several hypotheses revolving around strategic information system decisions. In this research, we posit that the eigenvalues of factor analysis along with the reduction in the uncertainty coefficients of the qualia entropy will be balanced by the quale enthalpy of our information theory structural equation model of trust, flexibility, expertise, top management support, and competitive advantage performance. We operationalize the integration of the aforementioned top management support, information systems competencies, and competitive advantage performance concepts into the qualia consciousness awareness and information theory quale framework. [ABSTRACT FROM AUTHOR]