Search

[Display omitted] • 28 out of 57 target PFAS were detected in paper products from China. • 9 groups of PFAS with 1–3 confidence levels were identified by non-target analysis. • Ethanol in food simulants can increase the migration of PFAS. • Long-chain PFAS in popcorn bags can be degraded by microwave heating. • PFAS in some paper products exceeded the recommended daily intake values. The contamination characteristics, migration patterns and health risks of per- and polyfluoroalkyl substances (PFAS) were investigated in 66 Chinese paper products by using target and non-target screening methods. Among 57 target PFASs, 5 and 6 PFASs were found in the hygiene paper products (

• AOs and PIs were detected in food packaging materials and magazines. • Food packaging materials had much higher concentrations than magazines. • Magazine front covers had much higher concentrations than magazine inside pages. • Exposure to AOs and PIs via contact with paper products is a minor exposure pathway. • This is the first simultaneous detection of a wide range of AOs/PIs in paper products. Although synthetic antioxidants (AOs) and photoinitiators (PIs) are known to be used in printing inks, there are little data on residual concentrations in printing paper products. In the present study, twenty-five PIs, ten AOs, and six transformation products were analyzed in two types of printing paper products, magazines and paperboard food packaging materials, both of which are unavoidable everyday products in our life. Nine AOs and six transformation products can be detected in food packaging materials with total concentrations (geometric mean, GM) of 1.16 × 104 ng/dm2. Twenty-two PIs were detected in food packaging materials with total concentrations (GM) of 1.76 × 104 ng/dm2. These chemicals were also detected in magazines, albeit at low concentrations (GM of AOs: 466 ng/dm2, GM of PIs: 1.17 × 103 ng/dm2). Magazine front covers were found to have much higher concentrations of the target compounds than magazine inside pages. Tris(2,4-di- tert -butylphenyl) phosphate (AO168O), 2,6-di- tert -butyl-4-methylphenol (BHT), bisphenol A (BPA), and benzophenone (BP) were among the predominant chemicals in those printing paper products. Preliminary calculations suggest that dermal exposure to AOs (GM: 6.25 ng/day) and PIs (GM: 17.0 ng/day) via contact with printing paper products is a minor exposure pathway compared to food intake/dust ingestion and is exceedingly unlikely to cause adverse health effects. [ABSTRACT FROM AUTHOR]

• New technical developments should facilitate that data are FAIR. • Implementation of common ontologies and data harmonization should enable data re-use. • Environment and Health (E&H) data should be part of the European Open Science Cloud. • Interconnect and synergize different research domains for optimal use of data. • An EU level E&H data research infrastructure is needed to support E&H research. Management of datasets that include health information and other sensitive personal information of European study participants has to be compliant with the General Data Protection Regulation (GDPR, Regulation (EU) 2016/679). Within scientific research, the widely subscribed'FAIR' data principles should apply, meaning that research data should be findable, accessible, interoperable and re-usable. Balancing the aim of open science driven FAIR data management with GDPR compliant personal data protection safeguards is now a common challenge for many research projects dealing with (sensitive) personal data. In December 2020 a workshop was held with representatives of several large EU research consortia and of the European Commission to reflect on how to apply the FAIR data principles for environment and health research (E&H). Several recent data intensive EU funded E&H research projects face this challenge and work intensively towards developing solutions to access, exchange, store, handle, share, process and use such sensitive personal data, with the aim to support European and transnational collaborations. As a result, several recommendations, opportunities and current limitations were formulated. New technical developments such as federated data management and analysis systems, machine learning together with advanced search software, harmonized ontologies and data quality standards should in principle facilitate the FAIRification of data. To address ethical, legal, political and financial obstacles to the wider re-use of data for research purposes, both specific expertise and underpinning infrastructure are needed. There is a need for the E&H research data to find their place in the European Open Science Cloud. Communities using health and population data, environmental data and other publicly available data have to interconnect and synergize. To maximize the use and re-use of environment and health data, a dedicated supporting European infrastructure effort, such as the EIRENE research infrastructure within the ESFRI roadmap 2021, is needed that would interact with existing infrastructures. [ABSTRACT FROM AUTHOR]

• Small relative effect sizes in observational studies often have policy importance. • Potential residual confounding in these studies lowers the certainty of the evidence. • Use of E-value and reference confounder improves assessment of residual confounding. • Unlikely residual confounding can be reason to upgrade the certainty of the evidence. • Case studies of reviews with small effects support the feasibility of the approach. Small relative effect sizes are common in observational studies of exposure in environmental and public health. However, such effects can still have considerable policy importance when the baseline rate of the health outcome is high, and many persons are exposed. Assessing the certainty of the evidence based on these effect sizes is challenging because they can be prone to residual confounding due to the non-randomized nature of the evidence. When applying GRADE, a precise relative risk >2.0 increases the certainty in an existing effect because residual confounding is unlikely to explain the association. GRADE also suggests rating up when opposing plausible residual confounding exists for other effect sizes. In this concept paper, we propose using the E-value, defined as the smallest effect size of a confounder that still can reduce an observed RR to the null value, and a reference confounder to assess the likelihood of residual confounding. We propose a 4-step approach. 1. Assess the association of interest for relevant exposure levels. 2. Calculate the E-value for this observed association. 3. Choose a reference confounder with sufficient strength and information and assess its effect on the observed association using the E-value. 4. Assess how likely it is that residual confounding will still bias the observed RR. We present three case studies and discuss the feasibility of the approach. [ABSTRACT FROM AUTHOR]

[Display omitted] "Biological plausibility" is a concept frequently referred to in environmental and public health when researchers are evaluating how confident they are in the results and inferences of a study or evidence review. Biological plausibility is not, however, a domain of one of the most widely-used approaches for assessing the certainty of evidence (CoE) which underpins the findings of a systematic review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) CoE Framework. Whether the omission of biological plausibility is a potential limitation of the GRADE CoE Framework is a topic that is regularly discussed, especially in the context of environmental health systematic reviews. We analyse how the concept of "biological plausibility", as applied in the context of assessing certainty of the evidence that supports the findings of a systematic review, is accommodated under the processes of systematic review and the existing GRADE domains. We argue that "biological plausibility" is a concept which primarily comes into play when direct evidence about the effects of an exposure on a population of concern (usually humans) is absent, at high risk of bias, is inconsistent, or limited in other ways. In such circumstances, researchers look toward evidence from other study designs in order to draw conclusions. In this respect, we can consider experimental animal and in vitro evidence as "surrogates" for the target populations, exposures, comparators and outcomes of actual interest. Through discussion of 10 examples of experimental surrogates, we propose that the concept of biological plausibility consists of two principal aspects: a "generalisability aspect" and a "mechanistic aspect". The "generalisability aspect" concerns the validity of inferences from experimental models to human scenarios, and asks the same question as does the assessment of external validity or indirectness in systematic reviews. The "mechanistic aspect" concerns certainty in knowledge of biological mechanisms and would inform judgements of indirectness under GRADE, and thus the overall CoE. While both aspects are accommodated under the indirectness domain of the GRADE CoE Framework, further research is needed to determine how to use knowledge of biological mechanisms in the assessment of indirectness of the evidence in systematic reviews. [ABSTRACT FROM AUTHOR]

Abstract: Taiwan''s EPA has implemented a new guideline called the “Plastic Products Restriction Policy”, prohibiting some industries to use plastics as packaging materials for the sake of sustainable use of resources. The significant effect resulting from this policy is the substitution of plastic products with paper products. Is this policy beneficial to achieve future sustainability? I attempt to analyze the resource choice between renewable resources and exhaustible resources for production of final products and services in case of exhaustion of natural resources. In this paper, I develop a framework to examine the dynamic responsiveness of a socio-economical system in facing a continual depletion of natural resources provided by an environmental system. In this framework, the status of an environmental system in terms of carrying capacity is affected by the cumulative impacts caused from human activities, including environmental pollution and resource exploitation. Conversely, it also affects the growth of renewable resources. This framework can serve as a guideline to construct indicators to measure the status of the environmental system and the socio-economical system in order to support a policy planner that formulates an appropriate environmental policy. Based on this framework, I also develop a mathematical model to determine the optimal ratio of resources choice between renewable resources and exhaustible resources. [Copyright &y& Elsevier]

In the past few decades, there has been a dramatic increase in scientific publications dealing with contaminants of emerging concern (CECs) and the escalating publication rate makes it close to impossible for individual researchers to get an overview of the field. Assuring the relevance and quality of the research conducted in any research field is a crucially important task. The rapidly increasing publication rates imply that review papers will play a progressively more central role to that end. The aim of the present paper is to critically assess whether reviews dealing with contaminants of emerging concern (CECs) are effective vehicles for a healthy dialogue about methodological weaknesses, uncertainties, research gaps and the future direction of the field. We carried out a tiered content-analysis of CEC review papers. Relevant papers were identified through searches in Web of Science (Clarivate), leading to the identification of 6391 original research papers of which 193 are review papers. We find that the majority of CEC reviews are written as if they are comprehensive, even though this clearly is not the case. A minority (~20%) take a critical-analytical approach to the reviewing task and identify weaknesses and research gaps. The following widespread tendencies in CEC research papers are commonly noted as concerning: to equate removal of CECs to 'decreased concentrations in the effluent'; to focus on parent substances and not concern oneself with degradation products; to focus on most commonly studied substances rather than those of most concern; to not deal with the corollary of our inability to detect or assess the risk for all substances, and to give insufficient attention to uncertainties and the unknown. Several critical-analytical reviews are among the highest cited, which suggests that they have the potential to function as effective vehicles for a healthy dialogue on these topics. On the other hand, it would appear that the concerns expressed in these reviews have a limited impact, as the same concerns are repeated over time. This might be due to a tendency among review authors to express their concerns implicitly, instead of clearly spelling them out. Our study suggests that CEC reviews presently fail to provide adequate and reliable guidance regarding the relevance and quality of research in the field. We argue that the overwhelming number of publications in combination with a lack of quality criteria for review papers are reasons to this failure: it is well documented that choices made during the reviewing process have a major impact on the outcome of a review. These choices include: search engine; the criteria used to include or exclude papers; the criteria used to assess the quality of the data generated in the research papers included; the criteria used for the choice of substances/ organisms/ technologies reported on. The lack of transparent procedures makes it very difficult, if not impossible, to assess the quality of the findings presented or to put those findings in context. In this light, it is noteworthy that criteria for a good review paper are rarely spelled out by peer-reviewed journals or included in instructions on scientific writing. The dramatic increase in publications is a challenge for the entire research community, particularly for research fields that are expected to provide policy-relevant data. We argue that only when peer-reviewed journals start specifying quality criteria for review papers, can such papers be relied upon to provide adequate and strategic guidance on the development of CEC research. We anticipate that our findings and conclusions are valid for many other research fields. • A minority of reviews of compounds of emerging concern (CECs) take a critical-analytical approach and identify weaknesses, research gaps or ways forward. • Serious concerns in CEC reviews: authors do not pay attention to substances of most concern, degradation products, or uncertainties. Equate removal with decreased concentration. • Critical analytical reviews have limited impact and the same concerns are repeatedly expressed over time. • The low quality of the majority of CEC reviews is worrisome and prevents reviews from effectively guiding future research. • Recommendation: Journals to spell out and act on quality criteria, else there is a risk that review papers perpetuate weaknesses in research rather than counteract them. [ABSTRACT FROM AUTHOR]

[Display omitted] • The exposure strength of MPs released from kitchens is raising. • The variety of kitchenware and cooking methods increases the release of MPs. • There may be links between some diseases with prolonged exposure to MPs. • Key challenges and directions for further research on MPs pollution are provided. The intensification of microplastics (MPs) pollution has emerged as a formidable environmental challenge, with profound global implications. The pervasive presence of MPs across a multitude of environmental mediums, such as the atmosphere, soil, and oceans, extends to commonplace items, culminating in widespread human ingestion and accumulation via channels like food, water, and air. In the domestic realm, kitchens have become significant epicenters for MPs pollution. A plethora of kitchen utensils, encompassing coated non-stick pans, plastic cutting boards, and disposable utensils, are known to release substantial quantities of MPs particles in everyday use, which can then be ingested alongside food. This paper conducts a thorough examination of contemporary research addressing the release of MPs from kitchen utensils during usage and focuses on the health risks associated with MPs ingestion, as well as the myriad factors influencing the release of MPs in kitchen utensils. Leveraging the insights derived from this analysis, this paper proposes a series of strategic recommendations and measures targeted at mitigating the production of MPs in kitchen settings. These initiatives are designed not solely to diminish the release of MPs but also to enhance public awareness regarding this pressing environmental concern. By adopting more informed practices in kitchens, we can significantly contribute to the reduction of the environmental burden of MPs pollution, thus safeguarding both human health and the ecological system. [ABSTRACT FROM AUTHOR]

[Display omitted] • Systematic review of experimental studies on RF-EMF effects on male fertility. • Risk of bias, inconsistency, publication bias weakened the certainty of results. • RF-EMF is unlike to decrease the fecundity of exposed male rodents. • RF-EMF may affect testicular tissue and sperm quality but the evidence is uncertain. • Impact on surrogate markers of fertility may not translate into functional effects. The World Health Organization is coordinating an international project aimed at systematically reviewing the evidence regarding the association between radiofrequency electromagnetic field (RF-EMF) exposure and adverse health effects. Reproductive health outcomes have been identified among the priority topics to be addressed. To evaluate the effect of RF-EMF exposure on male fertility of experimental mammals and on human sperm exposed in vitro. Three electronic databases (PubMed, Scopus and EMF Portal) were last searched on September 17, 2022. Two independent reviewers screened the studies, which were considered eligible if met the following criteria: 1) Peer-reviewed publications of sham controlled experimental studies, 2) Non-human male mammals exposed at any stage of development or human sperm exposed in vitro , 3) RF-EMF exposure within the frequency range of 100 kHz-300 GHz, including electromagnetic pulses (EMP), 4) one of the following indicators of reproductive system impairment: • decrease of fertility: rate of infertile males, rate of nonpregnant females, litter size and in vitro fertilization rate; • effects on semen quality : in animal studies sperm count, in both animal and in vitro studies sperm vitality, morphology and DNA/chromatin alterations; • reproductive organ toxicity: testis-epididymis weight, testis or epididymis histology, testis histomorphometry, testicular cell death, estimated testicular cell production; • hormonal effects : testosterone level. Two reviewers extracted study characteristics and outcome data. We assessed risk of bias (RoB) using the Office of Health Assessment and Translation (OHAT) guidelines. We categorized studies into 3 levels of overall RoB: low, some or high concern. We pooled study results in a random effects meta -analysis comparing average exposure to no-exposure and in a dose–response meta -analysis using all exposure doses. For experimental animal studies, we conducted subgroup analyses for species, Specific Absorption Rate (SAR) and temperature increase. We grouped studies on human sperm exposed in vitro by the fertility status of sample donors and SAR. We assessed the certainty of the evidence using the GRADE approach after excluding studies that were rated as "high concern" for RoB. One-hundred and seventeen papers on animal studies and 10 papers on human sperm exposed in vitro were included in this review. Only few studies were rated as "low concern" because most studies were at RoB for exposure and/or outcome assessment. Subgrouping the experimental animal studies by species, SAR, and temperature increase partly accounted for the heterogeneity of individual studies in about one third of the meta -analyses. In no case was it possible to conduct a subgroup analysis of the few human sperm in vitro studies because there were always 1 or more groups including less than 3 studies. Among all the considered endpoints, the meta -analyses of animal studies provided evidence of adverse effects of RF-EMF exposure in all cases but the rate of infertile males and the size of the sired litters. The assessment of certainty according to the GRADE methodology assigned a moderate certainty to the reduction of pregnancy rate and to the evidence of no-effect on litter size, a low certainty to the reduction of sperm count, and a very low certainty to all the other meta -analysis results. Studies on human sperm exposed in vitro indicated a small detrimental effect of RF-EMF exposure on vitality and no-effect on DNA/chromatin alterations. According to GRADE, a very low certainty was attributed to these results. The few studies that used EMP exposure did not show effects on the outcomes. A low to very low certainty was attributed to these results. Many of the studies examined suffered of severe limitations that led to the attribution of uncertainty to the results of the meta -analyses and did not allow to draw firm conclusions on most of the endpoints. Nevertheless, the associations between RF-EMF exposure and decrease of pregnancy rate and sperm count, to which moderate and low certainty were attributed, are not negligible, also in view of the indications that in Western countries human male fertility potential seems to be progressively declining. It was beyond the scope of our systematic review to determine the shape of the dose–response relationship or to identify a minimum effective exposure level. The subgroup and the dose–response fitting analyses did not show a consistent relationship between the exposure levels and the observed effects. Notably, most studies evaluated RF-EMF exposure levels that were higher than the levels to which human populations are typically exposed, and the limits set in international guidelines. For these reasons we cannot provide suggestions to confirm or reconsider current human exposure limits. Considering the outcomes of this systematic review and taking into account the limitations found in several of the studies, we suggest that further investigations with better characterization of exposure and dosimetry including several exposure levels and blinded outcome assessment were conducted. Protocol registration: Protocols for the systematic reviews of animal studies and of human sperm in vitro studies were published in Pacchierotti et al., 2021. The former was also registered in PROSPERO (CRD42021227729 https://www.crd.york.ac.uk/prospero/display%5frecord.php?RecordID = 227729) and the latter in Open Science Framework (OSF Registration DOI https://doi.org/10.17605/OSF.IO/7MUS3). [ABSTRACT FROM AUTHOR]

Exposure to ambient air pollution is associated with a significant number of deaths. Much of the evidence associating air pollution with adverse effects is from North American and Europe, partially due to incomplete data in other regions limiting location specific examinations. The aim of the current paper is to leverage satellite derived air quality data to examine the relationship between ambient particulate matter and all-cause and cause-specific mortality in Asia. Six cohorts from the Asia Cohort Consortium provided residential information for participants, recruited between 1991 and 2008, across six countries (Bangladesh, India, Iran, Japan, South Korea, and Taiwan). Ambient particulate material (PM 2·5) levels for the year of enrolment (or 1998 if enrolled earlier) were assigned utilizing satellite and sensor-based maps. Cox proportional models were used to examine the association between ambient air pollution and all-cause and cause-specific mortality (all cancer, lung cancer, cardiovascular and lung disease). Models were additionally adjusted for urbanicity (representing urban and built characteristics) and stratified by smoking status in secondary analyses. Country-specific findings were pooled via random-effects meta -analysis. More than 300,000 participants across six cohorts were included, representing more than 4-million-person years. A positive relationship was observed between a 5 µg/m (Dockery et al., 1993) increase in PM 2·5 and cardiovascular mortality (HR: 1·06, 95 % CI: 0.99, 1·13). The additional adjustment for urbanicity resulted in increased associations between PM 2.5 and mortality outcomes, including all-cause mortality (1·04, 95 % CI: 0·97, 1·11). Results were generally similar regardless of whether one was a current, never, or ex-smoker. Using satellite and remote sensing technology we showed that associations between PM 2.5 and all-cause and cause-specific Hazard Ratios estimated are similar to those reported for U.S. and European cohorts. This project was supported by the Health Effects Institute. Grant number #4963-RFA/18–5. Specific funding support for individual cohorts is described in the Acknowledgements. [ABSTRACT FROM AUTHOR]

• First review on radiation safety issue of activated tungsten dust for fusion reactor. • Source terms of activated tungsten dust were detailed. • Tungsten environmental migration and transformation behaviors were illustrated. • Distribution and health effects of tungsten in human body were reviewed. • R&D suggestions for radiation safety assessment of activated tungsten dust were proposed. Fusion energy investigation has stepped to a new stage adopting deuterium and tritium as fuels from the previous stage concentrating hydrogen plasma physics. Special radiation safety issues would be introduced during this stage. In addition to industrial and military uses, tungsten is also regarded as the most promising plasma facing material for fusion reactors. During the operation of fusion reactors, tungsten-based plasma facing materials can be activated via neutron nuclear reaction. Meanwhile, activated tungsten dust can be produced when high-energy plasma interacts with the tungsten-based plasma facing materials, namely plasma wall interaction. Activated tungsten dust would be an emerging environmental pollutant with radiation toxicity containing various radionuclides in addition to the chemical toxicity of tungsten itself. Nonetheless, the historical underestimation of its environmental availability has led to limited research on tungsten compared to other environmental contaminants. This paper presents the first systematic review on the safety issue of emerging activated tungsten dust, encompassing source terms, environmental behaviors, and health effects. The key contents are as follows: 1) to detail the source terms of activated tungsten dust from aspects of tungsten basic properties, generation mechanism, physical morphology and chemical component, radioactivity, as well as potential release pathways, 2) to illustrate the environmental behaviors from aspects of atmospheric dispersion and deposition, transformation and migration in soil, as well as plant absorption and distribution, 3) to identify the toxicity and health effects from aspects of toxicity to plants, distribution in human body, as well as health effects by radiation and chemical toxicity, 4) based on the research progress, research and development issues needed are also pointed out to better knowledge of safety issue of activated tungsten dust, which would be beneficial to the area of fusion energy and ecological impact caused by the routine tungsten related industrial and military applications. [ABSTRACT FROM AUTHOR]

[Display omitted] • In-train air quality in UK diesel trains tested for 13 different train classes. • Means were PM 10 : 8–52; PM 2.5 : 4–36; BC: 1–11; NO 2 : 28–201 (µg/m3); UFP: 225–9131 #/cm3. • Large in-train variability was observed and associated with multiple factors. • Trains under 10 years old had the lowest in-train PM concentrations. • UK diesel trains measured lower PM 2.5 and PNC than other transport modes. Concentrations of particulate matter (PM 10 , PM 2.5), ultrafine (UFP), particle number (PNC), black carbon (BC), nitrogen dioxide (NO 2) and nitrogen oxides (NO X) were measured in train carriages on diesel and bi-mode trains on inter-city and long-distance journeys in the United Kingdom (UK) using a high-quality mobile measurement system. Air quality on 15 different routes was measured using highly-time resolved data on a total of 119 journeys during three campaigns in winter 2020 and summer 2021; this included 13 different train classes. Each journey was sampled 4–10 times with approximatively 11,000 min of in-train concentrations in total. Mean-journey concentrations were 7.552 µg m−3 (PM 10); 3.936 µg m−3 (PM 2.5); 333–11,300 # cm−3 (PNC); 225–9,131 # cm−3 (UFP); 0.6–11 µg m−3 (BC); 28–201 µg m−3 (NO 2); and 130–3,456 µg m−3 (NO X). The impact of different factors on in-train concentrations was evaluated. The presence of tunnels was the factor with the largest impact on the in-train particle concentrations with enhancements by a factor of 40 greater than baseline for BC, and a factor 6 to 7 for PM and PNC. The engine fuel mode was the factor with the largest impact on NO 2 with enhancements of up to 14-times larger when the train run on diesel compared to the times running on electric on hybrid trains. Train classes with an age < 10 years observed the lowest in-train PM, BC and NO X concentrations reflecting improvements in aspects of rail technology in recent years. Air quality on UK diesel trains is higher than ambient concentrations but has lower PM 2.5 and PNC than most other transport modes, including subway systems, diesel and petrol cars. This paper adds significantly to the evidence on exposure to poor air quality in transport micro-environments and provides the industry and regulatory bodies with reference-grade measurements on which to establish in-train air quality guidelines. [ABSTRACT FROM AUTHOR]

[Display omitted] Applications emitting radiofrequency electromagnetic fields (RF-EMF; 100 kHz to 300 GHz) are widely used for communication (e.g. mobile phones), in medicine (diathermy) and in industry (RF heaters). The objective is to systematically review the effects of longer-term or repeated local and whole human body radiofrequency electromagnetic field (RF-EMF) exposure on the occurrence of symptoms. Primary hypotheses were tinnitus, migraine and headaches in relation to RF-EMF exposure of the brain, sleep disturbances and composite symptom scores in relation to whole-body RF-EMF exposure. Eligibility criteria: We included case-control and prospective cohort studies in the general population or workers estimating local or whole-body RF-EMF exposure for at least one week. Information sources: We conducted a systematic literature search in various databases including Web of Science and Medline. Risk of bias: We used the Risk of Bias (RoB) tool developed by OHAT adapted to the topic of this review. Synthesis of results: We synthesized studies using random effects meta -analysis. Included studies: We included 13 papers from eight distinct cohort and one case-control studies with a total of 486,558 participants conducted exclusively in Europe. Tinnitus is addressed in three papers, migraine in one, headaches in six, sleep disturbances in five, and composite symptom scores in five papers. Only one study addressed occupational exposure. Synthesis of results: For all five priority hypotheses, available research suggests that RF-EMF exposure below guideline values does not cause symptoms, but the evidence is very uncertain. The very low certainty evidence is due the low number of studies, possible risk of bias in some studies, inconsistencies, indirectness, and imprecision. In terms of non-priority hypotheses numerous exposure-outcome combinations were addressed in the 13 eligible papers without indication for an association related to a specific symptom or exposure source. Limitations of evidence: This review topic includes various challenges related to confounding control and exposure assessment. Many of these aspects are inherently present and not easy to be solved in future research. Since near-field exposure from wireless communication devices is related to lifestyle, a particular challenge is to differentiate between potential biophysical effects and other potential effects from extensive use of wireless communication devices that may compete with healthy behaviour such as sleeping or physical activity. Future research needs novel and innovative methods to differentiate between these two hypothetical mechanisms. Interpretation: This is currently the best available evidence to underpin safety of RF-EMF. There is no indication that RF-EMF below guideline values causes symptoms. However, inherent limitations of the research results in substantial uncertainty. Funding: This review was partially funded by the WHO radioprotection programme. Registration: The protocol for this review has been registered in Prospero (reg no CRD42021239432) and published in Environment International (Röösli et al., 2021) [ABSTRACT FROM AUTHOR]

• Proposed a multi-factor spatial disaggregation model based on principal component synthesis adjustment coefficients (PCAM). • Proposed a temporal disaggregation model based on the congestion delay index; • Increased the accuracy of NO 2 estimation by 34.5% with the proposed spatial disaggregation model; • First considering road slope factors, the disaggregation results in areas with large road slopes are more realistic; • The monitored pollutants data had some degree of time lag compared to the disaggregated. A high-accuracy gridding vehicle emission inventory is not only the foundation for developing refined emission control strategies but a necessary input to air quality model as well. An accurate approach to the spatiotemporal disaggregation is the key step to improving the accuracy of gridding emission inventories. The existing spatial disaggregation method considers relatively fewer impact factors, lacking adequate correlation analysis among impact factors. Additionally, the existing temporal disaggregation method does not correspond with the actual travel behavior of residents. This paper proposes a multi-factor spatial disaggregation model by principal component analysis (PCAM), based on a correlation analysis of the main impact factors. Further, a new temporal disaggregation model is proposed based on the congestion delay index combined with the traffic flow fundamental model (CDITF). The results from a case study in Jinan show that the square of correlation coefficients (RSQ) between the model- disaggregated NO 2 emissions based on PCAM and the monitored NO 2 concentration increased by 34.4% compared to the traditional disaggregation model based on the standard road length, and the RSQ for CO increased by 13%; the NMD and NME of the simulation results based on CMAQ model compared to standard road length model decrease by approximately 33.7% and 35.5%, respectively. The trend of the monthly, daily, and hourly variations of NO 2 and CO emissions disaggregated by the proposed temporal disaggregation model is quite consistent with that of the monitored concentration data. The PCAM method and the CDITF proposed in this paper are more in line with the actual situation using the cumulative emissions on road sections. The vehicle emissions in Jinan are found to be concentrated in the center of each district and county and near high-grade roads. The disaggregation results in areas with large road slopes are more realistic for considering road slope factors. The trend of the monthly, daily, and hourly variations of NO 2 and CO emissions disaggregated by the proposed temporal disaggregation model is quite consistent with that of the monitored concentration data, however, the monitored concentration data presents a certain degree of time lag. The proposed spatiotemporal disaggregation model in this paper improves the accuracy of gridding vehicle emission inventory, which is of a great significance for developing precise control strategies of vehicle emissions and improving the urban air quality in general. [ABSTRACT FROM AUTHOR]

This study assesses the antioxidant enzymes activities viz., catalase, glutathione peroxidase, glutathione S-transferase and nonenzymatic antioxidant molecule such as glutathione in Anguilla anguilla L. gill, kidney and liver in response to 8- and 48-h exposure to bleached kraft pulp mill effluent (BKPME). A. anguilla were caged and plunged at three different sites—50 (Site 1), 100 (Site 2) and 2000 m (Site 3) away from the closed BKPME outlet. A significant gill (8 and 48 h) and kidney (48 h) catalase activity decrease was observed at site 2 exposure whereas liver showed a significant increase in catalase activity after 8 and 48 h to site 1 exposure. Glutathione peroxidase (GPX) activity was significantly decreased in gill after 8-h exposure to site 1 and 48-h exposures to sites 1 and 2, respectively. Concerning gill, kidney and liver glutathione S-transferase (GST) activity, a significant gill GST activity decrease after 8 h at site 2 and 48 h at sites 1 and 2 was observed; in kidney, a significant decrease in its activity was observed after 48 h at sites 1 and 2, respectively, whereas in liver, the decrease was significant only at site 2 after 48-h exposure. The in situ BKPME exposure caused a significant total gill and kidney reduced glutathione (GSH) decrease after 8 h at site 2 exposure and after 48 h at site 1 and 2 exposures, respectively. However, a biphasic response was observed in liver, i.e. initial significant increase after 8 h at site 2 followed by a significant decrease after 48 h to the same site exposure. The enzymatic and nonenzymatic antioxidants pattern in gill and kidney, as observed in this study, was different than liver, demonstrating that the liver was more resistant to oxidative damage than gill and kidney. In addition, A. anguilla gill, kidney and liver antioxidants adaptation potentials may serve as a surrogate biomarker to BKPME exposure. [Copyright &y& Elsevier]

[Display omitted] • Cell metabolomics is a reliable and efficient tool to study PFAS toxicity. • Diverse cell types show non-specific and specific responses to PFAS. • Cell metabolomics approach revealed pathways associated with PFAS effects. • Cell metabolomics studies identified potential biomarkers linked to PFAS effects. Per- and polyfluoroalkyl substances (PFAS), ubiquitous environmental contaminants, pose significant challenges to ecosystems and human health. While cell cultures have emerged as new approach methodologies (NAMs) in ecotoxicity research, metabolomics is an emerging technique used to characterize the small-molecule metabolites present in cells and to understand their role in various biological processes. Integration of metabolomics with cell cultures, known as cell culture metabolomics, provides a novel and robust tool to unravel the complex molecular responses induced by PFAS exposure. In vitro testing also reduces reliance on animal testing, aligning with ethical and regulatory imperatives. The current review summarizes key findings from recent studies utilizing cell culture metabolomics to investigate PFAS toxicity, highlighting alterations in metabolic pathways, biomarker identification, and the potential linkages between metabolic perturbations. Additionally, the paper discusses different types of cell cultures and metabolomics methods used for studies of environmental contaminants and particularly PFAS. Future perspectives on the combination of metabolomics with other advanced technologies, such as single-cell metabolomics (SCM), imaging mass spectrometry (IMS), extracellular flux analysis (EFA), and multi-omics are also explored, which offers a holistic understanding of environmental contaminants. The synthesis of current knowledge and identification of research gaps provide a foundation for future investigations that aim to elucidate the complexities of PFAS-induced cellular responses and contribute to the development of effective strategies for mitigating their adverse effects on human health. [ABSTRACT FROM AUTHOR]

[Display omitted] • Estimating API emissions to wastewater on city-scale is feasible. • Choice of excretion fraction impacts model performance substantially. • Model-based emission estimation can offer an informative alternative for monitoring. • Availability + accessibility of use data limit application to other contaminants. With increasing numbers of chemicals used in modern society, assessing human and environmental exposure to them is becoming increasingly difficult. Recent advances in wastewater-based epidemiology enable valuable insights into public exposure to data-poor compounds. However, measuring all >26,000 chemicals registered under REACH is not just technically unfeasible but would also be incredibly expensive. In this paper, we argue that estimating emissions of chemicals based on usage data could offer a more comprehensive, systematic and efficient approach than repeated monitoring. Emissions of 29 active pharmaceutical ingredients (APIs) to wastewater were estimated for a medium-sized city in the Netherlands. Usage data was collected both on national and local scale and included prescription data, usage in health-care institutions and over-the-counter sales. Different routes of administration were considered as well as the excretion and subsequent in-sewer back-transformation of conjugates into respective parent compounds. Results suggest model-based emission estimation on a city-level is feasible and in good agreement with wastewater measurements obtained via passive sampling. Results highlight the need to include excretion fractions in the conceptual framework of emission estimation but suggest that the choice of an appropriate excretion fraction has a substantial impact on the resulting model performance. [ABSTRACT FROM AUTHOR]

[Display omitted] • According to SUHI difference, global cities were mainly divided into five grades. • Factor analysis was conducted based on TabNet for various indicators and grades. • The weight of △EVI for daytime SUHII gradually increased according to the grades. • Population and NTL affected nighttime SUHII of medium-value and high-value grades. Significant urbanization resulted in increasing surface urban heat island (SUHI) that caused negative impacts on urban ecological environment, and residential comfort. Accurately monitoring the spatiotemporal variations and understanding controls of SUHI were essential to propose effective mitigation measurements. However, SUHI grades across global cities remained unknown, which cloud greatly support for global mitigations. Additionally, quantitative evaluating factor weights for different SUHI indicators and grades worldwide remained further investigations. Therefore, this paper proposed SUHI grading based on agglomerative hierarchical clustering, and further quantified factor weights for different indicators and grades based on an interoperable machine learning named TabNet. There were three major findings. (1) Global cities were grouped into five grades, including SUCI (surface urban cool island), insignificant, low-value, medium-value, and high-value SUHI grades, indicating significant differences among different grades. SUHI grades showed significant climate-based variations, wherein the arid climate was dominated by the SUCI grade at daytime but the high-value grade at nighttime. (2) Vegetation difference was an important factor for daytime SUHII accounting for 27%. Daytime frequency of SUHI was controlled by vegetation difference, temperature, evaporation and nighttime light, accounting for 78%. The major factors for nighttime frequency were albedo differences and nighttime light, accounting for 45%. (3) Related factors contributed differently to various SUHI grades. The weight of △EVI for daytime SUHII gradually increased with grades, while it for daytime frequency and maximum duration of SUHI decreased with grades. The nighttime SUHII of the low-value grade was greatly affected by the background climate, while that of the medium-value and high-value grades were strongly impacted by anthropogenic heat flux. The diurnal contrast of grades and coupling effects with heat wave were further discussed. This paper aimed to provide information on grades and controls of SUHI for further mitigation proposal. [ABSTRACT FROM AUTHOR]

Abstract: The nonionic biodegradation-resistant (“hard”) alkylphenol ethoxylate (APEO) surfactants and their degradation products are known endocrine disrupting chemicals (EDCs). We report here the findings concerning the APEOs concentrations and homologic distribution profiles in Israel''s estuarine and coastal zone seawater to serve as a case study. The concentrations in sewage-containing rivers, estuaries and 50–60-m offshore sea (Mediterranean) water were found to be 12.5–75.1, 4.2–25.0 and 0.9–2.6 μg/L, respectively. The corresponding homologic distribution profiles were found to be within the range of 1–10% each, somewhat skewing, as expected, towards the more toxic shorter-chain ethoxylates. Egg production by zebrafish, exposed to 75, 25 and 10 μg/L of a typical industrial APEOs was reduced up to 89.6%, 84.7% and 76.9%, respectively, between the 8th and 28th days of exposure. Apparently, there is a potential APEOs-related ecotoxicological health risk problem. [Copyright &y& Elsevier]

Abstract: Chlorinated paraffins (also called polychlorinated n-alkanes — PCAs) are a class of industrial chemicals comprising chlorinated straight chain hydrocarbons. They have a wide range of applications and are now found in a range of environmental compartments. We analysed a total of 25 human milk-fat samples, donated by 18 individuals from the urban London and more rural Lancaster areas in the UK, for short chain PCAs (C10–C13 sPCAs) and medium chain PCAs (C14–C17 mPCAs), using gas chromatography–ECNI high-resolution mass spectrometry. Our study confirms that trace quantities of PCAs can reach human milk-fat. sPCAs were detected in all but four samples, while mPCAs were detected in all samples. The median sPCA concentration was 180 ng/g fat (range of 49 to 820 ng/g fat — detected values only) and the median mPCA concentration was 21 ng/g fat (range of 6.2 to 320 ng/g fat). No differences were noted in ranges of observed values for either sPCAs or mPCAs between samples from London and Lancaster. Most samples also exhibited similar patterns of sPCAs and mPCAs. One sample exhibited a different pattern for sPCAs and mPCAs, an observation that may be related to differences in exposure or biological factors for this individual. [Copyright &y& Elsevier]

This article attempts to analyze the main impacts of climate change on public health starting with global and going through local by analyzing coastal communities in the area of influence of Sundarbans, located in southwestern coastal region of Bangladesh. In dealing with paramount health problems caused by climate change, we discuss what are the major challenges faced by different actors. From the opinion of globalization and world system theory it will be argued that developing countries are facing major defiance in terms of mitigation and adaptation, including human health problems. Those living in developing world, as the case of Bangladesh, responsible for the lowest contributions to climate change, are already suffering the most. This paper is based on bibliographical and statistical review, and uses primary data collected from field and secondary from publications, books, scientific journals, international reports. In this paper we also focused that poor countries shall not be liable for the damages caused by carbon emissions already trapped into atmosphere, a historic problem caused by developed world, so we expect that multi-governance platforms should make mutual efforts to promote health in partnership with local institutions in order to solve the climatic crisis. • Unfortunately, developing countries which have contributed fewer amounts of GHG from beginning to right now, are the most affected and vulnerable countries due to climate change in conjunction with already suffering the consequences on human health. • A range of health risks such as vector-borne diseases problems capable of infecting human beings are linked with changeable weather patterns, as verified in the study region through primary data collection. Within the range of vector-borne diseases, dengue is more linked with global climatic pattern variation. • Scientific observation brings strong evidence with 98% of the inhabitants interviewed living in Southwestern coastal region of Bangladesh since childhood confirming that the sea level is rising, with more frequent tidal inundation. [ABSTRACT FROM AUTHOR]

Abstract Background Endometriosis is a gynaecological disease characterized by the presence of ectopic endometrial tissue that affects women during their reproductive years, having a strong impact on their lives, fertility and healthcare costs. The aetiology remains largely unknown, but current evidence suggests that it is multi-causal and oestrogen-dependent. Many epidemiologic studies have explored associations between organochlorine chemicals (OCCs) and endometriosis, but the findings are inconsistent. Objectives A systematic review (SR) and meta-analysis were conducted to gather and synthesize all the available evidence from human epidemiological studies about the associations between OCCs and endometriosis. Data sources The searches were conducted in PubMed and Web of Science in June 2016 with a final follow-up in August 2018. Study eligibility criteria Only human epidemiological studies were considered, independent of participant age, body mass index or life-stage. Studies reporting individual measures of exposure to OCCs were included, considering but not limited to polychlorinated dibenzodioxins and dibenzofurans (PCDD/Fs), polychlorinated biphenyls (PCBs), or organochlorine pesticides (OCPs). The primary health outcome was presence of endometriosis, including all sub-types. Eligibility criteria excluded articles not written in English, conference papers, reviews and studies with overlapping information. Study appraisal and synthesis methods A SR protocol pre-registered at PROSPERO was applied in duplicate to gather and extract all eligible original papers from PUBMED and Web of Science databases. Odds ratios were pooled using the inverse variance method for random effects meta-analysis for each group of OCCs. Risk of bias was assessed using the National Toxicology Program/Office of Health Assessment and Translation (NTP/OHAT) Risk of Bias Rating Tool for Human and Animal Studies adapted to the review question. The confidence in the body of evidence and related level of evidence was measured by using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) based NTP/OHAT framework. The results were structured and presented in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results Of the 51 studies retained for the full-text screening, 17 provided effect sizes and metrics sufficient for pooling estimates through meta-analysis. The overall odds ratios and 95% confidence intervals were 1.65 (1.14; 2.39) for dioxins (n = 10), 1.70 (1.20; 2.39) for PCBs (n = 9), and 1.23 (1.13; 1.36) for OCPs (n = 5). Despite being statistically significant, these estimates should be considered with caution given the notable heterogeneity and small estimated effect size. Misclassification of exposure, due to varying laboratory detection rate capabilities, and disease status, due to varying definitions of endometriosis, were identified as major sources of uncertainty. Limitations, conclusions, and implications of key findings The level of evidence was considered to be "moderate" with "serious" risk of bias according the NTP/OHAT criteria, supporting the need for further well-designed epidemiological research to fill lingering data gaps. Given the complexity of endometriosis and lack of known biomarkers suitable for population-based research, carefully designed observational studies play an important role in better understanding the aetiology of endometriosis, as will evolving mixture modeling approaches capable of handling various environmental chemical exposures. Attention to critical windows of exposure will shed further light on the possible developmental origin of endometriosis. Considering the high economic and societal cost associated with endometriosis, further research on this field is urged. Systematic review registration number CRD42018080956 Highlights • A first systematic review was conducted on the link between POPs and endometriosis. • Meta-analysis revealed positive associations for dioxins, PCBs and pesticides. • The level of evidence was rated "moderate" with "serious" risk of bias. [ABSTRACT FROM AUTHOR]

Micro-plastic and nano-particle have been the focal pollutants in environmental science. The printer toner is omitted micro-plastic and nano pollutant. It is comprised of micro polyacrylate styrene and nano-Fe 3 O 4 particles. Polyacrylate styrene and nano-metal were proved to be irreversibly toxic to biological cells. Therefore, toners have the potential environmental risk and healthy harm due to include micro plastics and nano-metal. To our knowledge, few studies provided the specific collection and treatment of micro-plastic pollutant. This paper has chosen a kind of micro-plastic and nano pollutant toxic toner and provided technical guidance and inspiration for controlling the micro-plastic and nano pollutants. The method of vacuum-gasification-condensation was adopted for controlling the micro-plastic and nano pollutant toner. We believe this review will open up a potential avenue for controlling micro-plastic and nano pollutants for environmental protection. [ABSTRACT FROM AUTHOR]

The present study aims to investigate how resource strategies, which intend to reduce waste and increase recycling, influence on human exposure to hazardous chemicals from material recycling. In order to examine the flows of hazardous chemicals in recycled material, a mass flow analysis of plastics and paper at European level, including the flow of phthalates, i.e. di(2-ethylhexyl) phthalate (DEHP), di-n-butyl phthalate (DBP), and benzyl-butyl phthalate (BBP), has been performed. The result for the year 2012 shows that 26% of plastic wastes and 60% of paper consumed in Europe were recycled. This corresponds to the finding that approximately 4% of DEHP and BBP and 18% of DBP annual demands in Europe as raw material re-enter the product cycle with recycled plastics and paper. To examine the potential contribution of the phthalate exposure through recycled plastics and paper, a case study assessing the childhood exposures to phthalates from foods packed in recycled paper and plastics has been performed for 2-year-old children in Denmark. The result verifies that an increase in recycled paperboard and PET bottles in food packaging material causes a significant increase in childhood exposure to DBP corresponding to an additional exposure of 0.116–0.355 μg/kg bw/day; up to 18% of the total DBP exposure in Danish 2-year-olds. While most of the DEHP exposure can be explained, more than 50% of DBP and 70% of BBP exposure sources still remain to be identified. Finally, a conceptual framework for a circular economy based on sustainable and clean resource flows is proposed in order to increase material recycling without increasing adverse health effects. [ABSTRACT FROM AUTHOR]

• The development of LUR approaches over the last decade was reviewed. • LCMs, mobile, and satellite data increase the spatiotemporal resolution of inputs. • Advanced statistics can better fit data with complex relationships and interactions. • LURs in the spatial form have been complemented by spatiotemporal models. • New developments to break through LUR methodologies were discussed. Land use regression (LUR) models are widely used in epidemiological and environmental studies to estimate humans' exposure to air pollution within urban areas. However, the early models, developed using linear regressions and data from fixed monitoring stations and passive sampling, were primarily designed to model traditional and criteria air pollutants and had limitations in capturing high-resolution spatiotemporal variations of air pollution. Over the past decade, there has been a notable development of multi-source observations from low-cost monitors, mobile monitoring, and satellites, in conjunction with the integration of advanced statistical methods and spatially and temporally dynamic predictors, which have facilitated significant expansion and advancement of LUR approaches. This paper reviews and synthesizes the recent advances in LUR approaches from the perspectives of the changes in air quality data acquisition, novel predictor variables, advances in model-developing approaches, improvements in validation methods, model transferability, and modeling software as reported in 155 LUR studies published between 2011 and 2023. We demonstrate that these developments have enabled LUR models to be developed for larger study areas and encompass a wider range of criteria and unregulated air pollutants. LUR models in the conventional spatial structure have been complemented by more complex spatiotemporal structures. Compared with linear models, advanced statistical methods yield better predictions when handling data with complex relationships and interactions. Finally, this study explores new developments, identifies potential pathways for further breakthroughs in LUR methodologies, and proposes future research directions. In this context, LUR approaches have the potential to make a significant contribution to future efforts to model the patterns of long- and short-term exposure of urban populations to air pollution. [ABSTRACT FROM AUTHOR]

[Display omitted] • Lack of comprehensive research on aerobiome resistome in freshwater environments. • The underexplored connection between bioaerosol resistomes and human health. • Insufficient data on how air resistome from other hotspots affects freshwater sources. • Need for routine monitoring of ARGs in freshwater aerobiomes. • Absence of studies on the direct relationship between air and freshwater resistomes. Antibiotic resistance genes (ARGs) are widespread environmental pollutants of biological origin that pose a significant threat to human, animal, and plant health, as well as to ecosystems. ARGs are found in soil, water, air, and waste, and several pathways for global dissemination in the environment have been described. However, studies on airborne ARG transport through atmospheric particles are limited. The ARGs in microorganisms inhabiting an environment are referred to as the "resistome". A global search was conducted of air-resistome studies by retrieving bioaerosol ARG-related papers published in the last 30 years from PubMed. We found that there is no dedicated methodology for isolating ARGs in bioaerosols; instead, conventional methods for microbial culture and metagenomic analysis are used in combination with standard aerosol sampling techniques. There is a dearth of information on the bioaerosol resistomes of freshwater environments and their impact on freshwater sources used for drinking and recreational activities. More studies of aerobiome freshwater environments are needed to ensure the safe use of water and sanitation. In this review we outline and synthesize the few studies that address the freshwater air microbiome (from tap water, bathroom showers, rivers, lakes, and swimming pools) and their resistomes, as well as the likely impacts on drinking and recreational waters. We also discuss current knowledge gaps for the freshwater airborne resistome. This review will stimulate new investigations of the atmospheric microbiome, particularly in areas where both air and water quality are of public health concern. [ABSTRACT FROM AUTHOR]

[Display omitted] • Conventional methods and sensors for microbial detection are summarized. • Typical sensing mechanisms for rapid detection are discussed. • Rapid sensors for monitoring food, water and environment were critically reviewed. • Insights for the future development on rapid sensors are provided. Conventional techniques (e.g., culture-based method) for bacterial detection typically require a central laboratory and well-trained technicians, which may take several hours or days. However, recent developments within various disciplines of science and engineering have led to a major paradigm shift in how microorganisms can be detected. The analytical sensors which are widely used for medical applications in the literature are being extended for rapid and on-site monitoring of the bacterial pathogens in food, water and the environment. Especially, within the low-resource settings such as low and middle-income countries, due to the advantages of low cost, rapidness and potential for field-testing, their use is indispensable for sustainable development of the regions. Within this context, this paper discusses analytical methods and biosensors which can be used to ensure food safety, water quality and environmental monitoring. In brief, most of our discussion is focused on various rapid sensors including biosensors and microfluidic chips. The analytical performances such as the sensitivity, specificity and usability of these sensors, as well as a brief comparison with the conventional techniques for bacteria detection, form the core part of the discussion. Furthermore, we provide a holistic viewpoint on how future research should focus on exploring the synergy of different sensing technologies by developing an integrated multiplexed, sensitive and accurate sensors that will enable rapid detection for food safety, water and environmental monitoring. [ABSTRACT FROM AUTHOR]

Wastewater is among the most important reservoirs of antibiotic resistance in urban environments. The abundance of carbon sources and other nutrients, a variety of possible electron acceptors such as oxygen or nitrate, the presence of particles onto which bacteria can adsorb, or a fairly stable pH and temperature are examples of conditions favouring the remarkable diversity of microorganisms in this peculiar habitat. The wastewater microbiome brings together bacteria of environmental, human and animal origins, many harbouring antibiotic resistance genes (ARGs). Although numerous factors contribute, mostly in a complex interplay, for shaping this microbiome, the effect of specific potential selective pressures such as antimicrobial residues or metals, is supposedly determinant to dictate the fate of antibiotic resistant bacteria (ARB) and ARGs during wastewater treatment. This paper aims to enrich the discussion on the ecology of ARB&ARGs in urban wastewater treatment plants (UWTPs), intending to serve as a guide for wastewater engineers or other professionals, who may be interested in studying or optimizing the wastewater treatment for the removal of ARB&ARGs. Fitting this aim, the paper overviews and discusses: i) aspects of the complexity of the wastewater system and/or treatment that may affect the fate of ARB&ARGs; ii) methods that can be used to explore the resistome, meaning the whole ARB&ARGs, in wastewater habitats; and iii) some frequently asked questions for which are proposed addressing modes. The paper aims at contributing to explore how ARB&ARGs behave in UWTPs having in mind that each plant is a unique system that will probably need a specific procedure to maximize ARB&ARGs removal. [ABSTRACT FROM AUTHOR]

Fluoride contamination of groundwater is a serious problem in several countries of the world because of the intake of excessive fluoride caused by the drinking of the contaminated groundwater. Geological and anthropogenic factors are responsible for the contamination of groundwater with fluoride. Excess amounts of fluoride in potable water may cause irreversible demineralisation of bone and tooth tissues, a condition called fluorosis, and long-term damage to the brain, liver, thyroid, and kidney. There has long been a need for fluoride removal from potable water to make it safe for human use. From among several defluoridation technologies, adsorption is the technology most commonly used due to its cost-effectiveness, ease of operation, and simple physical process. In this paper, the adsorption capacities and fluoride removal efficiencies of different types of adsorbents are compiled from relevant published data available in the literature and represented graphically. The most promising adsorbents tested so far from each category of adsorbents are also highlighted. There is still a need to discover the actual feasibility of usage of adsorbents in the field on a commercial scale and to define the reusability of adsorbents to reduce cost and the waste produced from the adsorption process. The present paper reviews the currently available methods and emerging approaches for defluoridation of water. [ABSTRACT FROM AUTHOR]

• Not including population changes lead to an average underestimation of the heat-health burden of 64 %. • Of the identified studies 45 % included changes in population size. • 23 % of studies included demographic change as changes in age structure. • Of the 15 studies using SSP-RCP scenarios 12 included implausible combinations. Anthropogenic climate change will have a detrimental impact on global health, including the direct impact of higher ambient temperatures. Existing projections of heat-related health outcomes in a changing climate often consider increasing ambient temperatures alone. Population growth and structure has been identified as a key source of uncertainty in future projections. Age acts as a modifier of heat risk, with heat-risk generally increasing in older age-groups. In many countries the population is ageing as lower birth rates and increasing life expectancy alter the population structure. Preparing for an older population, in particular in the context of a warmer climate should therefore be a priority in public health research and policy. We assess the level of inclusion of population growth and demographic changes in research projecting exposure to heat and heat-related health outcomes. To assess the level of inclusion of population changes in the literature, keyword searches of two databases were implemented, followed by reference and citation scans to identify any missed papers. Relevant papers, those including a projection of the heat health burden under climate change, were then checked for inclusion of population scenarios. Where sensitivity to population change was studied the impact of this on projections was extracted. Our analysis suggests that projecting the heat health burden is a growing area of research, however, some areas remain understudied including Africa and the Middle East and morbidity is rarely explored with most studies focusing on mortality. Of the studies pairing projections of population and climate, specifically SSPs and RCPs, many used pairing considered to be unfeasible. We find that not including any projected changes in population or demographics leads to underestimation of health burdens of on average 64 %. Inclusion of population changes increased the heat health burden across all but two studies. [ABSTRACT FROM AUTHOR]

Tributyltin (TBT) is a toxic chemical used for various industrial purposes such as slime control in paper mills, disinfection of circulating industrial cooling waters, antifouling agents, and the preservation of wood. Due to its widespread use as an antifouling agent in boat paints, TBT is a common contaminant of marine and freshwater ecosystems exceeding acute and chronic toxicity levels. TBT is the most significant pesticide in marine and freshwaters in Europe and consequently its environmental level, fate, toxicity and human exposure are of current concern. Thus, the European Union has decided to specifically include TBT compounds in its list of priority compounds in water in order to control its fate in natural systems, due to their toxic, persistent, bioaccumulative and endocrine disruptive characteristics. Additionally, the International Maritime Organization has called for a global treaty that bans the application of TBT-based paints starting 1 of January 2003, and total prohibition by 1 of January 2008. This paper reviews the state of the science regarding TBT, with special attention paid to the environmental levels, toxicity, and human exposure. TBT compounds have been detected in a number of environmental samples. In humans, organotin compounds have been detected in blood and in the liver. As for other persistent organic pollutants, dietary intake is most probably the main route of exposure to TBT compounds for the general population. However, data concerning TBT levels in foodstuffs are scarce. It is concluded that investigations on experimental toxicity, dietary intake, potential human health effects and development of new sustainable technologies to remove TBT compounds are clearly necessary. [Copyright &y& Elsevier]

Sulfonamides (SAs), a kind of commonly used antibiotics, have been frequently detected in the environment. Due to their potential threat to the ecological environment, the toxicity of SAs to bacteria have been determined in depth, and the toxic mechanism is found to target dihydropteroate synthase (DHPS). However, other toxic mechanism may also exist for SAs, which is still unclear to us. In this paper, the toxic mechanism of sulfachloropyridazine (SCP, as a representative of SAs) was investigated thoroughly on Aliivibrio fischeri (A. fischeri) from the perspective of quorum sensing (QS). The results reveal that SCP may act on three signaling pathways, i.e. , Pathway I, II and III, which triggers, maintains and destroys the homeostasis of A. fischeri respectively. In Pathway I, SCP changes the active form of LitR that regulates the expression of lux -related genes, inducing inhibition on bacterial growth while stimulation on luminescence; in Pathway II, SCP facilitates the production of C6HSL signaling molecules, maintaining the homeostasis in LitR and DHPS proteins; whereas in Pathway III, SCP typically combines with DHPS to inhibit the folate metabolism. This study can provide a deeper and more comprehensive understanding on the toxicity of SAs and help the environmental risk assessment of SAs. Unlabelled Image • SCP may act on three signaling pathways (Pathway I, II, and III) in A. fischeri. • SCP changes the active form of LitR to trigger the homeostasis in Pathway I. • SCP facilitates the C6HSL signals to maintain the homeostasis in Pathway II. • SCP combines with DHPS to destroy the homeostasis in Pathway III. [ABSTRACT FROM AUTHOR]

This paper presents the interaction of benzo[ a ]pyrene (B[ a ]P) with Cu(II)-montmorillonite to investigate the formation, evolution and potential toxicity of environmentally persistent free radicals (EPFRs) under dark and visible light irradiation conditions. Degradation of B[ a ]P and the generated transformative products on clay mineral are monitored by gas chromatography–mass spectrometry (GC–MS) technique. Hydroxyl-B[ a ]P and B[ a ]P-diones are observed during the transformation of B[ a ]P under dark condition. B[ a ]P-3,6-dione and B[ a ]P-6,12-dione are the main products under visible light irradiation. B[ a ]P transformation is accompanied by the formation of EPFRs, which are quantified by electron paramagnetic resonance (EPR) spectroscopy. With increasing reaction time, the concentrations of the produced EPFRs are initially increased and then gradually decrease to an undetectable level. The deconvolution results of EPR spectra reveal formation of three types of organic radicals (carbon-centered radicals, oxygen-centered radicals, and carbon-centered radicals with a conjugated oxygen), which also co-exist. Correspondingly, visible-light irradiation promotes the formation and the decay of these EPFRs. The produced B[ a ]P-type EPFRs induce the generation of reactive oxygen species (ROS), such as superoxide (O 2 –) and hydroxide radicals (OH), which may cause oxidative stress to cells and tissues of organisms. The toxicity of degradation products is evaluated by the livability of human gastric epithelial GES-1cells. The toxicity is initially increased and then decreases with the elapsed reaction time, which correlates with the evolution of EPFRs concentrations. The present work provides direct evidence that the formation of EPFRs in interaction of PAHs with metal-contaminated clays may result in negative effects to human health. Unlabelled Image • Cu-clay has great potential for catalytic B[ a ]P degradation in dark/light conditions. • The formation and decay of EPFR and ROS were monitored as a function of reaction time. • Potential evolution mechanism of B[ a ]P on Cu-smectite was systematically explored. • Toxicity of the generated radicals was examined against epithelial GES-1 cells. [ABSTRACT FROM AUTHOR]

Wastewater reuse is considered one of the most promising practices for the achievement of sustainable water management on a global scale. In the context of the safe reuse of water, membrane filtration is a competitive technique due to its superior efficiency in several processes. However, membrane fouling by organics is an inevitable challenge that is encountered during the practical application of membrane processes. The resolution of the membrane fouling challenge requires an in-depth understanding of many complex interactions between organic foulants and the membrane. In the last few decades, the forward osmosis (FO) membrane process, which exploits osmosis as a driving force, has emerged as an effective technology for water production with low energy consumption, thus leveraging the water-energy nexus. However, their successful application is severely hampered by membrane fouling, which is caused by such complex fouling mechanisms as cake enhanced osmotic pressure (CEOP), reverse salt diffusion (RSD), internal, and external concentration polarization as well as by the traditional fouling processes encompassing colloids, microbial (biofouling), inorganic, and organic fouling. Of these fouling types, the fouling potential of organic matter in FO has not been given sufficient attention, in particular, when FO is applied to wastewater treatment. This paper aims to provide a comprehensive overview of FO membrane fouling for wastewater applications with a special focus on the identification of the major factors that lead to the unique properties of organic fouling in this filtration process. Based on the critical assessment of organic fouling formation and the governing mechanisms, proposals were advanced for future research aimed at the mitigation of FO membrane fouling to enhance process efficiency in wastewater applications. • A first review to compare various factors influencing FO membrane fouling • Characterizing tools for FO membrane foulants are summarized. • Unique properties of foulant layer in FO were compared with those of RO. • Many factors for FO membrane fouling are identified and compared individually. [ABSTRACT FROM AUTHOR]

This paper describes the reduction of p-nitrophenol by green rusts (GRs) interlayered with common inorganic anions (Cl−, SO 4 2− and CO 3 2−). Modifying of GRs with zero-valent Cu nanoparticles (Cu0 NPs) can greatly enhance the reductive reactivity of GRs via the formation of a galvanic couple between the GRs and the Cu0 NPs, as confirmed by an increased corrosion current. The direct addition of Cu0 NPs excludes the possible formation of less active mono-valent Cu in the GRs/Cu2+ system. Oxidation of GRs does not occur upon the addition of Cu0 NPs, thus a decline in electron transfer from the oxidized GRs to the Cu0 NPs is avoided. The optimum Cu0 NPs loading on GR Cl is 0.5% wt. The GR Cl /Cu0 NPs retains high reactivity in the studied pH range from 7 to 10, while the presence of NO 3 −, PO 4 3−, SO 4 2−, CO 3 2– and humic acid inhibits PNP reduction by the GR Cl and GR Cl /Cu0 NPs. The GR Cl /Cu0 NPs system is less susceptible to the presence of CO 3 2– and humic acid compared to the pure GR Cl system due to the migration of the PNP reduction sites from the GRs to the Cu0 NPs. This work sheds light on a new strategy for enhancing GR-based materials for use in groundwater remediation. Unlabelled Image • Cu NPs can greatly enhance the reductive reactivity of GR. • GR/Cu NPs is more reactive than GR/Cu2+ system. • The Cu NPs loading on GR is optimized. • GR/Cu NPs remains high reactivity at pH from 7 to 10. • GR/Cu NPs is less susceptible to the presence of CO 3 2– and humic acid compared to pure GR. [ABSTRACT FROM AUTHOR]

• 86 long-range atmospheric dust events were identified to reach Finland. • 59 were Saharan, 22 were Aral-Caspian, and five were from the Middle East in origin. • Number and proportion of scarce winter events have more than doubled since 2010. • All winter dust storm events were associated with freezing rain. Studies on atmospheric dust and long-range transport of mineral dust have been a focus of atmospheric science in recent years. With its wide range of direct and indirect effects, mineral dust is one of the most uncertain elements in the mechanisms of climate change, and a deeper understanding of its role is essential for understanding future processes. The aim of our research was to provide the first systematic data on the so far episodically documented northward transport mineral dust from arid-semiarid areas. So, in this paper, we present dust storm events from lower latitudes reaching the Finnish atmosphere, based on the MERRA-2 model Dust Column Mass Density data and after a multistep verification procedure using independent data source. In total, 86 long-range dust storm events were identified between 1980 and 2022, when air masses loaded with dust reached Finland. Based on backward-trajectories different sources were identified: 59 were Saharan, 22 were Aral-Caspian, and five were associated with Middle Eastern source areas. Considerable variation in inter-annual frequencies was observed among the source areas, which may be due to changes in circulation conditions and the effects of human activity (agriculture and land use changes in Aral Sea region). There is a clear maximum of dust events in spring (60%), followed by summer and autumn (where 10 of the 11 autumn episodes were from the Sahara). However, the number and proportion of scarce winter events have more than doubled since 2010 compared to the preceding 30 years, but no autumn events were registered during this period. This clear temporal variation coincides with changes in dust transport observed in other regions of Europe, driven by greater atmospheric meridionality associated with climate change and driven by reduced temperature difference between low and high latitudes due to enhanced temperature increases at Arctic regions. [ABSTRACT FROM AUTHOR]

[Display omitted] The World Health Organization is coordinating an international project aimed at systematically reviewing the evidence regarding the association between radiofrequency electromagnetic field (RF-EMF) exposure and adverse health effects. Within the project, 6 topics have been prioritized by an expert group, which include reproductive health outcomes. According to the protocol published in 2021, a systematic review and meta -analyses on the adverse effects of RF-EMF exposure during pregnancy in offspring of experimental animals were conducted. Three electronic databases (PubMed, Scopus and EMF Portal) were last searched on September 8 or 17, 2022. Based on predefined selection criteria, the obtained references were screened by two independent reviewers. Studies were included if they met the following criteria: 1) original, sham controlled experimental study on non-human mammals exposed in utero , published in peer-reviewed journals, 2) the experimental RF-EMF exposure was within the frequency range 100 kHz–300 GHz, 3) the effects of RF-EMF exposure on fecundity (litter size, embryonic/fetal losses), on the offspring health at birth (decrease of weight or length, congenital malformations, changes of sex ratio) or on delayed effects (neurocognitive alterations, female infertility or early-onset cancer) were studied. Study characteristics and outcome data were extracted by two reviewers. Risk of bias (RoB) was assessed using the Office of Health Assessment and Translation (OHAT) guidelines. Study results were pooled in a random effects meta -analysis comparing average exposure to no-exposure and in a dose–response meta -analysis using all exposure doses, after exclusion of studies that were rated at "high concern" for RoB. Subgroup analyses were conducted for species, Specific Absorption Rate (SAR) and temperature increase. The certainty of the evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. Eighty-eight papers could be included in this review. Effects on fecundity. The meta -analysis of studies on litter size, conducted at a whole-body average SAR of 4.92 W/kg, did not show an effect of RF-EMF exposure (MD 0.05; 95% CI −0.21 to 0.30). The meta -analysis of studies on resorbed and dead fetuses, conducted at a whole-body average SAR of 20.26 W/kg, showed a significant increase of the incidence in RF-EMF exposed animals (OR 1.84; 95% CI 1.27 to 2.66). The results were similar in the dose–response analysis. Effects on the offspring health at birth. The meta -analysis of studies on fetal weight, conducted at a whole-body average SAR of 9.83 W/kg, showed a small decrease in RF-EMF exposed animals (SMD 0.31; 95% CI 0.15 to 0.48). The meta -analysis of studies on fetal length, conducted at a whole-body average SAR of 4.55 W/kg, showed a moderate decrease in length at birth (SMD 0.45; 95% CI 0.07 to 0.83). The meta -analysis of studies on the percentage of fetuses with malformations, conducted at a whole-body average SAR of 6.75 W/kg, showed a moderate increase in RF-EMF exposed animals (SMD −0.45; 95% CI −0.68 to −0.23). The meta -analysis of studies on the incidence of litters with malformed fetuses, conducted at a whole-body average SAR of 16.63 W/kg, showed a statistically significant detrimental RF-EMF effect (OR 3.22; 95% CI 1.9 to 5.46). The results were similar in the dose–response analyses. Delayed effects on the offspring health. RF-EMF exposure was not associated with detrimental effects on brain weight (SMD 0.10; 95% CI −0.09 to 0.29) and on learning and memory functions (SMD −0.54; 95% CI −1.24 to 0.17). RF-EMF exposure was associated with a large detrimental effect on motor activity functions (SMD 0.79; 95% CI 0.21 to 1.38) and a moderate detrimental effect on motor and sensory functions (SMD −0.66; 95% CI −1.18 to −0.14). RF-EMF exposure was not associated with a decrease of the size of litters conceived by F2 female offspring (SMD 0.08; 95% CI −0.39 to 0.55). Notably, meta -analyses of neurobehavioural effects were based on few studies, which suffered of lack of independent replication deriving from only few laboratories. There was high certainty in the evidence for a lack of association of RF-EMF exposure with litter size. We attributed a moderate certainty to the evidence of a small detrimental effect on fetal weight. We also attributed a moderate certainty to the evidence of a lack of delayed effects on the offspring brain weight. For most of the other endpoints assessed by the meta -analyses, detrimental RF-EMF effects were shown, however the evidence was attributed a low or very low certainty. The body of evidence had limitations that did not allow an assessment of whether RF-EMF may affect pregnancy outcomes at exposure levels below those eliciting a well-known adverse heating impact. In conclusion, in utero RF-EMF exposure does not have a detrimental effect on fecundity and likely affects offspring health at birth, based on the meta -analysis of studies in experimental mammals on litter size and fetal weight, respectively. Regarding possible delayed effects of in utero exposure, RF-EMF probably does not affect offspring brain weight and may not decrease female offspring fertility; on the other hand, RF-EMF may have a detrimental impact on neurobehavioural functions, varying in magnitude for different endpoints, but these last findings are very uncertain. Further research is needed on the effects at birth and delayed effects with sample sizes adequate for detecting a small effect. Future studies should use standardized endpoints for testing prenatal developmental toxicity and developmental neurotoxicity (OECD TG 414 and 426), improve the description of the exposure system design and exposure conditions, conduct appropriate dosimetry characterization, blind endpoint analysis and include several exposure levels to better enable the assessment of a dose-response relationship. The protocol was published in Pacchierotti et al., 2021 and registered in PROSPERO CRD42021227746 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=227746). [ABSTRACT FROM AUTHOR]

[Display omitted] POD diffusive samplers loaded with Carbopack X and Carbograph 5TD were exposed to certified calibration mixtures containing a total of 110 different ozone precursor and air toxic compounds. Constant sampling rates were identified for 39 ozone precursors and 33 air toxics. As 9 of these compounds were included in both mixtures, this meant a total of 63 different volatile and very volatile compounds were sampled using the POD with overall expanded uncertainties below 30 % for the sampling rate associated with the whole range of sampling times from 2 to 24 h. Carbograph 5TD exhibited superior performance for diffusive sampling of oxygenated and halogenated compounds in the air toxics mixture, while Carbopack X showed higher sampling efficiencies for aliphatic and aromatic hydrocarbons, as well as halogenated compounds derived from benzene and C 2 carbon number hydrocarbons. A model has been developed and applied to estimate sampling rates, primarily for the more volatile and weakly adsorbed compounds, as a function of the collected amount of analyte and the exposure time. For an additional 9 ozone precursors on Carbopack X, and 11 air toxics on Carbograph 5TD, the expanded uncertainties of modelled sampling rates were reduced to below 30 % and have a significantly reduced uncertainty compared to those associated with an averaged sampling rate. The paper provides Freundlich's isotherm parameters for the estimated (modelled) sampling rates and defines a pragmatic approach to their application. It does so by identifying the best sampling time to use for the expected exposure concentrations and associated analyte masses. This allows for expansion of the sampling concentration range from hundreds ng m−3 to mg m−3, while avoiding saturation of the adsorbent. Finally, field measurement comparisons of POD samplers, pumped tube samplers and online gas chromatography (GC), for sampling periods of 3 and 7 days in a semi-rural background area, showed no significant differences between reported concentrations. [ABSTRACT FROM AUTHOR]

[Display omitted] • ISIAQ STC34 has an open database of IEQ guidelines. • Thermal conditions (e.g., T and RH) and indoor pollutants (e.g., CO 2 , CH 2 O, PM, NO 2 , CO, and Rn) can be impacted by energy saving measures. • Health based guidelines exist for CH 2 O, PM 2.5 , PM 10 , NO 2 , CO, and Rn. • Guidelines can help in creating a balance between energy conservation, thermal comfort, and good IAQ. Buildings are constructed and operated to satisfy human needs and improve quality of life. Good indoor air quality (IAQ) and thermal comfort are prerequisites for human health and well-being. For their provision, buildings often rely on heating, ventilation, and air conditioning (HVAC) systems, which may lead to higher energy consumption. This directly impacts energy efficiency goals and the linked climate change considerations. The balance between energy use, optimum IAQ and thermal comfort calls for scientifically solid and well-established limit values for exposures experienced by building occupants in indoor spaces, including homes, schools, and offices. The present paper aims to appraise limit values for selected indoor pollutants reported in the scientific literature, and to present how they are handled in international and national guidelines and standards. The pollutants include carbon dioxide (CO 2), formaldehyde (CH 2 O), particulate matter (PM), nitrogen dioxide (NO 2), carbon monoxide (CO), and radon (Rn). Furthermore, acknowledging the particularly strong impact on energy use from HVAC, ventilation, indoor temperature (T), and relative humidity (RH) are also included, as they relate to both thermal comfort and the possibilities to avoid moisture related problems, such as mould growth and proliferation of house dust mites. Examples of national regulations for these parameters are presented, both in relation to human requirements in buildings and considering aspects related to energy saving. The work is based on the Indoor Environmental Quality (IEQ) guidelines database, which spans across countries and institutions, and aids in taking steps in the direction towards a more uniform guidance for values of indoor parameters. The database is coordinated by the Scientific and Technical Committee (STC) 34, as part of ISIAQ, the International Society of Indoor Air Quality and Climate. [ABSTRACT FROM AUTHOR]

[Display omitted] The environment is an important component in the emergence and transmission of antimicrobial resistance (AMR). Despite that, little effort has been made to monitor AMR outside of clinical and veterinary settings. Partially, this is caused by a lack of comprehensive reference data for the vast majority of environments. To enable monitoring to detect deviations from the normal background resistance levels in the environment, it is necessary to establish a baseline of AMR in a variety of settings. In an attempt to establish this baseline level, we here performed a comprehensive literature survey, identifying 150 scientific papers containing relevant qPCR data on antimicrobial resistance genes (ARGs) in environments associated with potential routes for AMR dissemination. The collected data included 1594 samples distributed across 30 different countries and 12 sample types, in a time span from 2001 to 2020. We found that for most ARGs, the typically reported abundances in human impacted environments fell in an interval from 10-5 to 10-3 copies per 16S rRNA, roughly corresponding to one ARG copy in a thousand bacteria. Altogether these data represent a comprehensive overview of the occurrence and levels of ARGs in different environments, providing background data for risk assessment models within current and future AMR monitoring frameworks. [ABSTRACT FROM AUTHOR]

[Display omitted] • High levels of aerosols from many swine farms pose a risk to health. • The air in swine farms contained higher amount of potential pathogens, resistant microorganisms, and resistance genes compared to human living and working environments. • Fewer airborne bacteria and viruses in swine farms were present in small-size particles, while the proportion of airborne fungi in respirable fraction was higher. • The differences of microorganism community structure and particles with small size (<1 μm) between swine farms and human living and working environments were not quite clear. With the rapid development of large-scale and intensive swine production, the emission of aerosols from swine farms has become a growing concern, attracting extensive attention. While aerosols are found in various environments, those from swine farms are distinguished from human habitats, such as residential, suburban, and urban areas. In order to gain a comprehensive understanding of aerosols from swine farms, this paper reviewed relevant studies conducted between 2000 and 2022. The main components, concentrations, and size distribution of the aerosols were systematically reviewed. The differences between aerosols from swine farms and human living and working environments were compared. Finally, the sources, influencing factors, and reduction technologies for aerosols from swine farms were thoroughly elucidated. The results demonstrated that the concentrations of aerosols inside swine farms varied considerably, and most exceeded safety thresholds. However, further exploration is needed to fully understand the difference in airborne microorganism community structure and particles with small sizes (<1 μm) between swine farms and human living and working environments. More airborne bacterial and viruses were adhered to large particles in swine houses, while the proportion of airborne fungi in the respirable fraction was similar to that of human living and working environments. In addition, swine farms have a higher abundance and diversity of potential pathogens, airborne resistant microorganisms and resistant genes compared to the human living and working environments. The aerosols of swine farms mainly originated from sources such as manure, feed, swine hair and skin, secondary production, and waste treatment. According to the source analysis and factors influencing aerosols in swine farms, various technologies could be employed to mitigate aerosol emissions, and some end-of-pipe technologies need to be further improved before they are widely applied. Swine farms are advised not to increase aerosol concentration in human living and working environments, in order to decrease the impact of aerosols from swine farms on human health and restrain the spread of airborne potential pathogens. This review provides critical insights into aerosols of swine farms, offering guidance for taking appropriate measures to enhance air quality inside and surrounding swine farms. [ABSTRACT FROM AUTHOR]

[Display omitted] Oxidative stress and tissue damage (OSD) play a pivotal role as an early-stage process in chronic disease pathogenesis. However, there has been little research to better understand the temporal (χρόνος[chronos]) dimensions of OSD process associated with environmental (non-genetic, including behaviors/lifestyle) and/or occupational stressors, like night shift work. OSD processes have recently attracted attention in relation to time-resolved external stressor trajectories in personalized medicine (prevention) initiatives, as they seem to interact with circadian clock systems towards the improved delineation of the early stages of (chronic) disease process. This work critically reviewed human studies targeting the temporal dynamics of OSD and circadian clock system's activity in response to environmental/occupational stressors; the case of night shift work was examined. Being a key stressor influencing OSD processes and circadian rhythm, night shift work was evaluated as part of a scoping review of research in OSD, including inflammatory and metabolic processes to determine the extent of OSD research undertaken in human populations, methodologies, tools and biomarkers used and the extent that the temporal dimensions of exposure and biological effect(s) were accounted for. Online databases were searched for papers published from 2000 onwards, resulting in the selection of 53 original publications. The majority of studies (n = 41) took place in occupational settings, while the rest were conducted in the general population or patient groups. Most occupational studies targeted outcomes of oxidative stress/damage (n = 19), followed by the combination of OSD with inflammatory response (n = 10), and studies focused on metabolic outcomes (n = 12). Only a minor fraction of the studies measured biomarkers related to circadian rhythm, such as, melatonin, its metabolite, or cortisol. Night shift work was associated with select biomarkers of OSD and inflammation, albeit with mixed results. Although much progress in delineating the biological mechanisms of OSD process has been made, an equally thorough investigation on the temporal trajectory of OSD processes as triggered by environmental/occupational stressors in human studies has yet to fully evolve. [ABSTRACT FROM AUTHOR]

• Global gap-free and fine-scale CO 2 data during 2014–2020 is generated. • This dataset exhibits high accuracy and fine resolution compared with other data. • Global spatiotemporal patterns and national-level growth rates of CO 2 are revealed. Carbon dioxide (CO 2) is a crucial greenhouse gas with substantial effects on climate change. Satellite-based remote sensing is a commonly used approach to detect CO 2 with high precision but often suffers from extensive spatial gaps. Thus, the limited availability of data makes global carbon stocktaking challenging. In this paper, a global gap-free column-averaged dry-air mole fraction of CO 2 (XCO 2) dataset with a high spatial resolution of 0.1° from 2014 to 2020 is generated by the deep learning-based multisource data fusion, including satellite and reanalyzed XCO 2 products, satellite vegetation index data, and meteorological data. Results indicate a high accuracy for 10-fold cross-validation (R2 = 0.959 and RMSE = 1.068 ppm) and ground-based validation (R2 = 0.964 and RMSE = 1.010 ppm). Our dataset has the advantages of high accuracy and fine spatial resolution compared with the XCO 2 reanalysis data as well as that generated from other studies. Based on the dataset, our analysis reveals interesting findings regarding the spatiotemporal pattern of CO 2 over the globe and the national-level growth rates of CO 2. This gap-free and fine-scale dataset has the potential to provide support for understanding the global carbon cycle and making carbon reduction policy, and it can be freely accessed at https://doi.org/10.5281/zenodo.7721945. [ABSTRACT FROM AUTHOR]

• A systematic review was conducted of associations between pesticide exposure and pregnancy duration with a large conceptual coverage of pesticides. • Quantitative meta -analysis was performed for overall pesticides and specific pesticide metabolites whenever possible. • The results suggested moderate evidence of an association between pesticide exposure and higher risk of preterm birth. • More attention is required on pesticide compounds in addition to organochlorine and organophosphorus pesticides, and on windows of susceptibility. Maternal pesticide exposure might be associated with adverse pregnancy outcomes through triggering inflammation and oxidative stress and disrupting endocrine functions. Yet the association between prenatal pesticide exposure and risk of preterm birth remains inconclusive. To conduct a systematic review and meta -analysis of human observational studies using the Office of Health Assessment and Translation (OHAT) framework to explore the association of per ten-fold increase of pesticide concentrations in maternal biological samples during pregnancy with risk of preterm birth and length of gestational age at birth. Five English (PubMed, Embase, Cochrane Library, Web of Science and Scopus) and 3 Chinese databases (China national knowledge infrastructure (CNKI), Wanfang Data, and Chinese Biomedical Literature Database (CBM)) were searched till Jan 18th, 2023. To be included, pesticide exposure should be measured in maternal biological samples during pregnancy and in log-transformed forms. The primary outcome was preterm birth and the secondary outcome was gestational age at birth. Quality of studies was evaluated using OHAT Risk of Bias Tool. Evidence was quantitatively synthesized with Correlated and Hierarchical Effects (CHE) model. The confidence rating in the body of evidence was done using OHAT. A total of 21 studies reported by 18 papers were included, with 7 studies for preterm birth and 19 for gestational age at birth. The meta -analysis found a ten-fold increase of pesticide concentrations was potentially associated with risk of preterm birth (pooled OR = 1.28; 95%CI: 0.93, 1.78) and shortened gestational age at birth (β = −0.10; 95%CI: −0.21, 0.01). Sampling biospecimens in different trimesters was identified as a potential modifier in the association between pesticide exposure and length of gestational age (F = 2.77, P < 0.05). For studies that collected samples at any time during pregnancy, pesticide exposure was found to be associated with shortened length of gestational age (β = −0.43; 95%CI: −0.81, −0.06). The confidence rating in the body of evidence was "moderate" and "very low" for preterm birth and gestational age at birth, respectively. Our result suggested moderate evidence of an association between pesticide exposure and higher risk of preterm birth. Yet more studies are still needed with larger sample size and careful considerations of confounders and accuracy of outcome measurements. Attention is also required on other pesticide compounds in addition to organochlorine and organophosphorus pesticides, and on windows of susceptibility. [ABSTRACT FROM AUTHOR]

[Display omitted] The World Health Organization (WHO) and the International Labour Organization (ILO) are developing joint estimates of the work-related burden of disease and injury (WHO/ILO Joint Estimates), with contributions from a large number of individual experts. Evidence from human, animal and mechanistic data suggests that occupational exposure to dusts and/or fibres (silica, asbestos and coal dust) causes pneumoconiosis. In this paper, we present a systematic review and meta -analysis of the prevalences and levels of occupational exposure to silica, asbestos and coal dust. These estimates of prevalences and levels will serve as input data for estimating (if feasible) the number of deaths and disability-adjusted life years that are attributable to occupational exposure to silica, asbestos and coal dust, for the development of the WHO/ILO Joint Estimates. We aimed to systematically review and meta -analyse estimates of the prevalences and levels of occupational exposure to silica, asbestos and coal dust among working-age (≥ 15 years) workers. We searched electronic academic databases for potentially relevant records from published and unpublished studies, including Ovid Medline, PubMed, EMBASE, and CISDOC. We also searched electronic grey literature databases, Internet search engines and organizational websites; hand-searched reference lists of previous systematic reviews and included study records; and consulted additional experts. We included working-age (≥ 15 years) workers in the formal and informal economy in any WHO and/or ILO Member State but excluded children (< 15 years) and unpaid domestic workers. We included all study types with objective dust or fibre measurements, published between 1960 and 2018, that directly or indirectly reported an estimate of the prevalence and/or level of occupational exposure to silica, asbestos and/or coal dust. At least two review authors independently screened titles and abstracts against the eligibility criteria at a first stage and full texts of potentially eligible records at a second stage, then data were extracted from qualifying studies. We combined prevalence estimates by industrial sector (ISIC-4 2-digit level with additional merging within Mining, Manufacturing and Construction) using random-effects meta -analysis. Two or more review authors assessed the risk of bias and all available authors assessed the quality of evidence, using the ROB-SPEO tool and QoE-SPEO approach developed specifically for the WHO/ILO Joint Estimates. Eighty-eight studies (82 cross-sectional studies and 6 longitudinal studies) met the inclusion criteria, comprising > 2.4 million measurements covering 23 countries from all WHO regions (Africa, Americas, Eastern Mediterranean, South-East Asia, Europe, and Western Pacific). The target population in all 88 included studies was from major ISCO groups 3 (Technicians and Associate Professionals), 6 (Skilled Agricultural, Forestry and Fishery Workers), 7 (Craft and Related Trades Workers), 8 (Plant and Machine Operators and Assemblers), and 9 (Elementary Occupations), hereafter called manual workers. Most studies were performed in Construction, Manufacturing and Mining. For occupational exposure to silica, 65 studies (61 cross-sectional studies and 4 longitudinal studies) were included with > 2.3 million measurements collected in 22 countries in all six WHO regions. For occupational exposure to asbestos, 18 studies (17 cross-sectional studies and 1 longitudinal) were included with > 20,000 measurements collected in eight countries in five WHO regions (no data for Africa). For occupational exposure to coal dust, eight studies (all cross-sectional) were included comprising > 100,000 samples in six countries in five WHO regions (no data for Eastern Mediterranean). Occupational exposure to silica, asbestos and coal dust was assessed with personal or stationary active filter sampling; for silica and asbestos, gravimetric assessment was followed by technical analysis. Risk of bias profiles varied between the bodies of evidence looking at asbestos, silica and coal dust, as well as between industrial sectors. However, risk of bias was generally highest for the domain of selection of participants into the studies. The largest bodies of evidence for silica related to the industrial sectors of Construction (ISIC 41–43), Manufacturing (ISIC 20, 23–25, 27, 31–32) and Mining (ISIC 05, 07, 08). For Construction, the pooled prevalence estimate was 0.89 (95% CI 0.84 to 0.93, 17 studies, I2 91%, moderate quality of evidence) and the level estimate was rated as of very low quality of evidence. For Manufacturing, the pooled prevalence estimate was 0.85 (95% CI 0.78 to 0.91, 24 studies, I2 100%, moderate quality of evidence) and the pooled level estimate was rated as of very low quality of evidence. The pooled prevalence estimate for Mining was 0.75 (95% CI 0.68 to 0.82, 20 studies, I2 100%, moderate quality of evidence) and the pooled level estimate was 0.04 mg/m3 (95% CI 0.03 to 0.05, 17 studies, I2 100%, low quality of evidence). Smaller bodies of evidence were identified for Crop and animal production (ISIC 01; very low quality of evidence for both prevalence and level); Professional, scientific and technical activities (ISIC 71, 74; very low quality of evidence for both prevalence and level); and Electricity, gas, steam and air conditioning supply (ISIC 35; very low quality of evidence for both prevalence and level). For asbestos, the pooled prevalence estimate for Construction (ISIC 41, 43, 45,) was 0.77 (95% CI 0.65 to 0.87, six studies, I2 99%, low quality of evidence) and the level estimate was rated as of very low quality of evidence. For Manufacturing (ISIC 13, 23–24, 29–30), the pooled prevalence and level estimates were rated as being of very low quality of evidence. Smaller bodies of evidence were identified for Other mining and quarrying (ISIC 08; very low quality of evidence for both prevalence and level); Electricity, gas, steam and air conditioning supply (ISIC 35; very low quality of evidence for both prevalence and level); and Water supply, sewerage, waste management and remediation (ISIC 37; very low quality of evidence for levels). For coal dust, the pooled prevalence estimate for Mining of coal and lignite (ISIC 05), was 1.00 (95% CI 1.00 to 1.00, six studies, I2 16%, moderate quality of evidence) and the pooled level estimate was 0.77 mg/m3 (95% CI 0.68 to 0.86, three studies, I2 100%, low quality of evidence). A small body of evidence was identified for Electricity, gas, steam and air conditioning supply (ISIC 35); with very low quality of evidence for prevalence, and the pooled level estimate being 0.60 mg/m3 (95% CI −6.95 to 8.14, one study, low quality of evidence). Overall, we judged the bodies of evidence for occupational exposure to silica to vary by industrial sector between very low and moderate quality of evidence for prevalence, and very low and low for level. For occupational exposure to asbestos, the bodies of evidence varied by industrial sector between very low and low quality of evidence for prevalence and were of very low quality of evidence for level. For occupational exposure to coal dust, the bodies of evidence were of very low or moderate quality of evidence for prevalence, and low for level. None of the included studies were population-based studies (i.e., covered the entire workers' population in the industrial sector), which we judged to present serious concern for indirectness, except for occupational exposure to coal dust within the industrial sector of mining of coal and lignite. Selected estimates of the prevalences and levels of occupational exposure to silica by industrial sector are considered suitable as input data for the WHO/ILO Joint Estimates, and selected estimates of the prevalences and levels of occupational exposure to asbestos and coal dust may perhaps also be suitable for estimation purposes. Protocol identifier: https://doi.org/10.1016/j.envint.2018.06.005. PROSPERO registration number: CRD42018084131. [ABSTRACT FROM AUTHOR]

To address limitations of observational epidemiology studies of air pollution and health effects, including residual confounding by temporal and spatial factors, several studies have taken advantage of ‘natural experiments’, where an environmental policy or air quality intervention has resulted in reductions in ambient air pollution concentrations. Researchers have examined whether the population impacted by these air quality improvements, also experienced improvements in various health indices (e.g. reduced morbidity/mortality). In this paper, I review key accountability studies done previously and new studies done over the past several years in Beijing, Atlanta, London, Ireland, and other locations, describing study design and analysis strengths and limitations of each. As new ‘natural experiment’ opportunities arise, several lessons learned from these studies should be applied when planning a new accountability study. Comparison of health outcomes during the intervention to both before and after the intervention in the population of interest, as well as use of a control population to assess whether any temporal changes in the population of interest were also seen in populations not impacted by air quality improvements, should aid in minimizing residual confounding by these long term time trends. Use of either detailed health records for a population, or prospectively collected data on relevant mechanistic biomarkers coupled with such morbidity/mortality data may provide a more thorough assessment of if the intervention beneficially impacted the health of the community, and if so by what mechanism(s). Further, prospective measurement of a large suite of air pollutants may allow a more thorough understanding of what pollutant source(s) is/are responsible for any health benefit observed. The importance of using multiple statistical analysis methods in each paper and the difference in how the timing of the air pollution/outcome association may impact which of these design features is most important is also discussed. Based on these and other lessons learned, researchers may provide a more epidemiologically rigorous evaluation of cause-specific health impacts of an air quality intervention or action. [ABSTRACT FROM AUTHOR]

The European Study of Cohorts for Air Pollution Effects (ESCAPE) is a13-nation study of long-term health effects of air pollution based on subjects pooled from up to 22 cohorts that were intended for other purposes. Twenty-five papers have been published on associations of various health endpoints with long-term exposures to NOx, NO2, traffic indicators, PM10, PM2.5 and PM constituents including absorbance (elemental carbon). Seven additional ESCAPE papers found moderate correlations (R2 = 0.3–0.8) between measured air quality and estimates based on land-use regression that were used; personal exposures were not considered. I found no project summaries or comparisons across papers; here I conflate the 25 ESCAPE findings in the context of other recent European epidemiology studies. Because one ESCAPE cohort contributed about half of the subjects, I consider it and the other 18 cohorts separately to compare their contributions to the combined risk estimates. I emphasize PM2.5 and confirm the published hazard ratio of 1.14 (1.04–1.26) per 10 μg/m3 for all-cause mortality. The ESCAPE papers found 16 statistically significant (p < 0.05) risks among the125 pollutant-endpoint combinations; 4 each for PM2.5 and PM10, 1 for PM absorbance, 5 for NO2, and 2 for traffic. No PM constituent was consistently significant. No significant associations were reported for cardiovascular mortality; low birthrate was significant for all pollutants except PM absorbance. Based on associations with PM2.5, I find large differences between all-cause death estimates and the sum of specific-cause death estimates. Scatterplots of PM2.5 mortality risks by cause show no consistency across the 18 cohorts, ostensibly because of the relatively few subjects. Overall, I find the ESCAPE project inconclusive and I question whether the efforts required to estimate exposures for small cohorts were worthwhile. I suggest that detailed studies of the large cohort using historical exposures and additional cardiovascular risk factors might be productive. [ABSTRACT FROM AUTHOR]

Bisphenol A (BPA) is a widely used chemical in the production of many polycarbonate plastics, epoxy resin linings for food and beverage containers and thermal papers. Oral intakes from the contaminated diets were considered as the predominant source of BPA exposure for humans. However, due to the high levels of BPA on thermal receipts and their wide applications in our daily life, the amount of BPA be transferred to the skin after holding thermal paper should not be underestimated, particularly for cashiers. To investigate the contribution of BPA exposure levels via the dermal contact route and the relationship between BPA exposure level and oxidative DNA damage, six male volunteers were recruited and required to simulate the cashiers' work and handle the thermal receipts during the study period. Triclosan (TCS, an antimicrobial compound used widely in personal health and skin care products) was applied as a reference compound. Their urinary BPA, TCS and 8-hydroxy-2′-deoxyguanosine (8-OHdG) concentrations were determined by high performance liquid chromatography/ tandem spectrometer (LC/MS/MS). The results showed that after handling the thermal receipts, the urinary BPA concentrations of volunteers increased 3 times of those before the experimental period. But TCS levels in urine kept stable. There existed a correlation between BPA exposure and 8-OHdG (R 2 = 0.237, p < 0.001), but not between TCS and 8-OHdG concentrations (R 2 = 0.026, p < 0.777), indicating that more BPA exposure could lead to higher oxidative DNA damage. That the increases in 8-OHdG levels in urine being almost consistent with those of BPA suggested that handling thermal receipts resulted in the increasing BPA intakes and BPA exposure was correlated with DNA oxidative damage. After 48 h of the end of handling thermal receipts, the urinary BPA levels did not descend to the levels before experiment, suggesting that the excretion of BPA via dermal contact was over 48 h. BPA exposure through dermal contact route contributed 51.9% to 84% to urinary BPA levels with the GM ratio of 70.9% for cashiers, indicating that it might be seriously underestimated for cashiers according to the previous studies. More attentions should be paid on the exposure of BPA via dermal penetration for cashiers. [ABSTRACT FROM AUTHOR]

• The production of TCR is unequally distributed across regions. • Net importers of embodied TCR are mainly focused on the east and west coastal areas. • The non-metallic and metallic products sectors are the most important sectors. • The largest portion of embodied TCR were triggered by households' final demand. • High-income groups account for high percent of total TCR footprint. Toxic chemicals have severe impacts on ecosystem, climate change and human health, and the current toxic releases are inequitably distributed across regions. Investigating the toxic release embodied in final demand by states and income groups can reveal the responsibility transfer of different entities. In this paper, we extended the U.S. multi-regional input–output (MRIO) model with toxic chemical release data in 2017 to conduct the production- and consumption-based accounting of toxic release by each state, and the inter-regional transfer of embodied toxic release between states. In addition, this paper analyzed how the toxic releases and inter-state transfer of embodied toxic release have been driven by income groups across states. The results showed that the toxic release from production was highly concentrated on the central states and the Great Lakes Region, while the consumption-based accounting of toxic release was more equally distributed across regions in the US. The non-metallic and metallic products manufacturing sectors were the most important sectors for most states from both production and consumption-based perspectives and were also the most essential sectors for interregional flows of embodied toxic release from Great Lake Region to Southeast, Mid-Atlantic and Northeast. Our results also showed that the largest portion (41.88%) of embodied toxic releases were triggered by households' final demand, and that the consumption of the richest 35% of households contributed to more than 50% of the total toxic chemical releases triggered by total final demand of all households. [ABSTRACT FROM AUTHOR]