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Your search keyword '"Maricel V. Maffini"' showing total 2 results
Start Over Author "Maricel V. Maffini" Journal environment international
2 results on '"Maricel V. Maffini"'

1. A vision for safer food contact materials: Public health concerns as drivers for improved testing

Author

Jane Muncke, Anna-Maria Andersson, Thomas Backhaus, Scott M. Belcher, Justin M. Boucher, Bethanie Carney Almroth, Terrence J. Collins, Birgit Geueke, Ksenia J. Groh, Jerrold J. Heindel, Frank A. von Hippel, Juliette Legler, Maricel V. Maffini, Olwenn V. Martin, John Peterson Myers, Angel Nadal, Cristina Nerin, Ana M. Soto, Leonardo Trasande, Laura N. Vandenberg, Martin Wagner, Lisa Zimmermann, R. Thomas Zoeller, and Martin Scheringer

Subjects
Food packaging, Hazard assessment, Chronic disease, Chemical safety, Environmental sciences, GE1-350
Abstract

Food contact materials (FCMs) and food contact articles are ubiquitous in today’s globalized food system. Chemicals migrate from FCMs into foodstuffs, so called food contact chemicals (FCCs), but current regulatory requirements do not sufficiently protect public health from hazardous FCCs because only individual substances used to make FCMs are tested and mostly only for genotoxicity while endocrine disruption and other hazard properties are disregarded. Indeed, FCMs are a known source of a wide range of hazardous chemicals, and they likely contribute to highly prevalent non-communicable diseases. FCMs can also include non-intentionally added substances (NIAS), which often are unknown and therefore not subject to risk assessment. To address these important shortcomings, we outline how the safety of FCMs may be improved by (1) testing the overall migrate, including (unknown) NIAS, of finished food contact articles, and (2) expanding toxicological testing beyond genotoxicity to multiple endpoints associated with non-communicable diseases relevant to human health. To identify mechanistic endpoints for testing, we group chronic health outcomes associated with chemical exposure into Six Clusters of Disease (SCOD) and we propose that finished food contact articles should be tested for their impacts on these SCOD. Research should focus on developing robust, relevant, and sensitive in-vitro assays based on mechanistic information linked to the SCOD, e.g., through Adverse Outcome Pathways (AOPs) or Key Characteristics of Toxicants. Implementing this vision will improve prevention of chronic diseases that are associated with hazardous chemical exposures, including from FCMs.

Published
2023
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2. Overview of intentionally used food contact chemicals and their hazards

Author

Jane Muncke, Ksenia J. Groh, Birgit Geueke, Maricel V. Maffini, and Olwenn V. Martin

Subjects
Food contact materials, 010504 meteorology & atmospheric sciences, Endocrine disruption, Food Contamination, 010501 environmental sciences, 01 natural sciences, Hazardous Substances, Health hazard, Persistence, Environmental hazard, intentionally added substance (IAS), health hazard, Hazardous waste, substitution, Intentionally added substance (IAS), Environmental planning, lcsh:Environmental sciences, environmental hazard, 0105 earth and related environmental sciences, General Environmental Science, lcsh:GE1-350, Food contact, Food Packaging, endocrine disruption, persistence, Hazard, Identification (information), Food, Chemical constituents, Business, food contact material, Food contact material
Abstract

Copyright © 2020 The Authors. Food contact materials (FCMs) are used to make food contact articles (FCAs) that come into contact with food and beverages during, e.g., processing, storing, packaging, or consumption. FCMs/FCAs can cause chemical contamination of food when migration of their chemical constituents (known as food contact chemicals, FCCs) occurs. Some FCCs are known to be hazardous. However, the total extent of exposure to FCCs, as well as their health and environmental effects, remain unknown, because information on chemical structures, use patterns, migration potential, and health effects of FCCs is often absent or scattered across multiple sources. Therefore, we initiated a research project to systematically collect, analyze, and publicly share information on FCCs. As a first step, we compiled a database of intentionally added food contact chemicals (FCCdb), presented here. The FCCdb lists 12′285 substances that could possibly be used worldwide to make FCMs/FCAs, identified based on 67 FCC lists from publicly available sources, such as regulatory lists and industry inventories. We further explored FCCdb chemicals’ hazards using several authoritative sources of hazard information, including (i) classifications for health and environmental hazards under the globally harmonized system for classification and labeling of chemicals (GHS), (ii) the identification of chemicals of concern due to endocrine disruption or persistence related hazards, and (iii) the inclusion on selected EU- or US-relevant regulatory lists of hazardous chemicals. This analysis prioritized 608 hazardous FCCs for further assessment and substitution in FCMs/FCAs. Evaluation based on non-authoritative, predictive hazard data (e.g., by in silico modeling or literature analysis) highlighted an additional 1411 FCCdb substances that could thus present similar levels of concern, but have not been officially classified so far. Lastly, for over a quarter of all FCCdb chemicals no hazard information could be found in the sources consulted, revealing a significant data gap and research need. MAVA Foundation; Valery Foundation

Published
2020

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