40 results on '"Slama, Rémy"'
Search Results
2. Traffic-Related Atmospheric Pollutants Levels during Pregnancy and Offspring's Term Birth Weight: A Study Relying on a Land-Use Regression Exposure Model
- Author
-
Slama, Rémy, Cyrys, Josef, Herbarth, Olf, Wichmann, Heinz-Erich, and Heinrich, Joachim
- Published
- 2007
Catalog
3. The International Collaboration on Air Pollution and Pregnancy Outcomes: initial results.
- Author
-
Parker, Jennifer D, Rich, David Q, Glinianaia, Svetlana V, Leem, Jong Han, Wartenberg, Daniel, Bell, Michelle L, Bonzini, Matteo, Brauer, Michael, Darrow, Lyndsey, Gehring, Ulrike, Gouveia, Nelson, Grillo, Paolo, Ha, Eunhee, van den Hooven, Edith H, Jalaludin, Bin, Jesdale, Bill M, Lepeule, Johanna, Morello-Frosch, Rachel, Morgan, Geoffrey G, Slama, Rémy, Pierik, Frank H, Pesatori, Angela Cecilia, Sathyanarayana, Sheela, Seo, Juhee, Strickland, Matthew, Tamburic, Lillian, and Woodruff, Tracey J more...
- Subjects
Humans ,Premature Birth ,Birth Weight ,Pregnancy Outcome ,Risk Factors ,Cohort Studies ,Feasibility Studies ,Pilot Projects ,Air Pollution ,Pregnancy ,Particle Size ,Research Design ,International Cooperation ,Socioeconomic Factors ,Infant ,Newborn ,Infant ,Low Birth Weight ,Female ,Particulate Matter ,air pollution ,birth weight ,ICAPPO ,low birth weight ,particulate matter ,pregnancy ,Infant ,Newborn ,Low Birth Weight ,Prevention ,Perinatal Period - Conditions Originating in Perinatal Period ,Infant Mortality ,Clinical Research ,Pediatric ,Climate-Related Exposures and Conditions ,2.5 Research design and methodologies ,Toxicology ,Medical and Health Sciences ,Environmental Sciences - Abstract
BackgroundThe findings of prior studies of air pollution effects on adverse birth outcomes are difficult to synthesize because of differences in study design.ObjectivesThe International Collaboration on Air Pollution and Pregnancy Outcomes was formed to understand how differences in research methods contribute to variations in findings. We initiated a feasibility study to a) assess the ability of geographically diverse research groups to analyze their data sets using a common protocol and b) perform location-specific analyses of air pollution effects on birth weight using a standardized statistical approach.MethodsFourteen research groups from nine countries participated. We developed a protocol to estimate odds ratios (ORs) for the association between particulate matter ≤ 10 μm in aerodynamic diameter (PM₁₀) and low birth weight (LBW) among term births, adjusted first for socioeconomic status (SES) and second for additional location-specific variables.ResultsAmong locations with data for the PM₁₀ analysis, ORs estimating the relative risk of term LBW associated with a 10-μg/m³ increase in average PM₁₀ concentration during pregnancy, adjusted for SES, ranged from 0.63 [95% confidence interval (CI), 0.30-1.35] for the Netherlands to 1.15 (95% CI, 0.61-2.18) for Vancouver, with six research groups reporting statistically significant adverse associations. We found evidence of statistically significant heterogeneity in estimated effects among locations.ConclusionsVariability in PM₁₀-LBW relationships among study locations remained despite use of a common statistical approach. A more detailed meta-analysis and use of more complex protocols for future analysis may uncover reasons for heterogeneity across locations. However, our findings confirm the potential for a diverse group of researchers to analyze their data in a standardized way to improve understanding of air pollution effects on birth outcomes. more...
- Published
- 2011
4. Early-Life Exposure to a Mixture of Phenols and Phthalates in Relation to Child Social Behavior: Applying an Evidence-Based Prioritization to a Cohort with Improved Exposure Assessment
- Author
-
Mustieles, Vicente, primary, Rolland, Matthieu, additional, Pin, Isabelle, additional, Thomsen, Cathrine, additional, Sakhi, Amrit K., additional, Sabaredzovic, Azemira, additional, Muckle, Gina, additional, Guichardet, Karine, additional, Slama, Rémy, additional, and Philippat, Claire, additional more...
- Published
- 2023
- Full Text
- View/download PDF
5. Meeting report: atmospheric pollution and human reproduction.
- Author
-
Slama, Rémy, Darrow, Lyndsey, Parker, Jennifer, Woodruff, Tracey J, Strickland, Matthew, Nieuwenhuijsen, Mark, Glinianaia, Svetlana, Hoggatt, Katherine J, Kannan, Srimathi, Hurley, Fintan, Kalinka, Jaroslaw, Srám, Radim, Brauer, Michael, Wilhelm, Michelle, Heinrich, Joachim, and Ritz, Beate more...
- Subjects
Humans ,Environmental Health ,Air Pollution ,Environmental Exposure ,Reproduction ,Pregnancy ,Models ,Theoretical ,Female ,Male ,Congresses as Topic ,atmospheric pollution ,bias ,birth weight ,environment ,exposure assessment ,fecundity ,geographic information system ,intrauterine growth restriction ,particulate matter ,pregnancy ,reproduction ,small for gestational age ,Pediatric Research Initiative ,Climate-Related Exposures and Conditions ,Prevention ,Infant Mortality ,Perinatal Period - Conditions Originating in Perinatal Period ,Preterm ,Low Birth Weight and Health of the Newborn ,Pediatric ,Aetiology ,2.1 Biological and endogenous factors ,Reproductive health and childbirth ,Good Health and Well Being ,Environmental Sciences ,Medical and Health Sciences ,Toxicology - Abstract
BackgroundThere is a growing body of epidemiologic literature reporting associations between atmospheric pollutants and reproductive outcomes, particularly birth weight and gestational duration.ObjectivesThe objectives of our international workshop were to discuss the current evidence, to identify the strengths and weaknesses of published epidemiologic studies, and to suggest future directions for research.DiscussionParticipants identified promising exposure assessment tools, including exposure models with fine spatial and temporal resolution that take into account time-activity patterns. More knowledge on factors correlated with exposure to air pollution, such as other environmental pollutants with similar temporal variations, and assessment of nutritional factors possibly influencing birth outcomes would help evaluate importance of residual confounding. Participants proposed a list of points to report in future publications on this topic to facilitate research syntheses. Nested case-control studies analyzed using two-phase statistical techniques and development of cohorts with extensive information on pregnancy behaviors and biological samples are promising study designs. Issues related to the identification of critical exposure windows and potential biological mechanisms through which air pollutants may lead to intrauterine growth restriction and premature birth were reviewed.ConclusionsTo make progress, this research field needs input from toxicology, exposure assessment, and clinical research, especially to aid in the identification and exposure assessment of feto-toxic agents in ambient air, in the development of early markers of adverse reproductive outcomes, and of relevant biological pathways. In particular, additional research using animal models would help better delineate the biological mechanisms underpinning the associations reported in human studies. more...
- Published
- 2008
6. Phenol and Phthalate Effects on Thyroid Hormone Levels during Pregnancy: Relying on In Vitro Assays and Adverse Outcome Pathways to Inform an Epidemiological Analysis
- Author
-
Nakiwala, Dorothy, primary, Noyes, Pamela D., additional, Faure, Patrice, additional, Chovelon, Benoît, additional, Corne, Christelle, additional, Gauchez, Anne Sophie, additional, Guergour, Dorra, additional, Lyon-Caen, Sarah, additional, Sakhi, Amrit K., additional, Sabaredzovic, Azemira, additional, Thomsen, Cathrine, additional, Pin, Isabelle, additional, Slama, Rémy, additional, and Philippat, Claire, additional more...
- Published
- 2022
- Full Text
- View/download PDF
7. Exposure to Phthalates and Phenols during Pregnancy and Offspring Size at Birth
- Author
-
Philippat, Claire, Mortamais, Marion, Chevrier, Cécile, Petit, Claire, Calafat, Antonia M., Ye, Xiaoyun, Silva, Manori J., Brambilla, Christian, Pin, Isabelle, Charles, Marie-Aline, Cordier, Sylvaine, and Slama, Rémy more...
- Published
- 2012
8. Birth Weight and Prenatal Exposure to Polychlorinated Biphenyls (PCBs) and Dichlorodiphenyldichloroethylene (DDE): A Meta-analysis within 12 European Birth Cohorts
- Author
-
OBELIX/ENRIECO, Govarts, Eva, Nieuwenhuijsen, Mark, Schoeters, Greet, Ballester, Ferran, Bloemen, Karolien, de Boer, Michiel, Chevrier, Cécile, Eggesbø, Merete, Guxens, Mònica, Krämer, Ursula, Legler, Juliette, Martínez, David, Palkovicova, Lubica, Patelarou, Evridiki, Ranft, Ulrich, Rautio, Arja, Petersen, Maria Skaalum, Slama, Rémy, Stigum, Hein, Toft, Gunnar, Trnovec, Tomas, Vandentorren, Stéphanie, Weihe, Pál, Kuperus, Nynke Weisglas, Wilhelm, Michael, Wittsiepe, Jürgen, and Bonde, Jens Peter more...
- Published
- 2012
9. European Birth Cohorts for Environmental Health Research
- Author
-
Vrijheid, Martine, Casas, Maribel, Bergström, Anna, Carmichael, Amanda, Cordier, Sylvaine, Eggesbø, Merete, Eller, Esben, Fantini, Maria P., Fernández, Mariana F., Fernández-Somoano, Ana, Gehring, Ulrike, Grazuleviciene, Regina, Hohmann, Cynthia, Karvonen, Anne M., Keil, Thomas, Kogevinas, Manolis, Koppen, Gudrun, Krämer, Ursula, Kuehni, Claudia E., Magnus, Per, Majewska, Renata, Andersen, Anne-Marie Nybo, Patelarou, Evridiki, Petersen, Maria Skaalum, Pierik, Frank H., Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Santos, Ana Cristina, Slama, Rémy, Sram, Radim J., Thijs, Carel, Tischer, Christina, Toft, Gunnar, Trnovec, Tomáš, Vandentorren, Stephanie, Vrijkotte, Tanja G.M., Wilhelm, Michael, Wright, John, and Nieuwenhuijsen, Mark more...
- Published
- 2012
10. Maternal Exposure to Nitrogen Dioxide during Pregnancy and Offspring Birth Weight: Comparison of Two Exposure Models
- Author
-
EDEN Mother—Child Cohort Study Group, Lepeule, Johanna, Caïni, Fabrice, Bottagisi, Sébastien, Galineau, Julien, Hulin, Agnès, Marquis, Nathalie, Bohet, Aline, Siroux, Valérie, Kaminski, Monique, Charles, Marie-Aline, and Slama, Rémy more...
- Published
- 2010
11. Maternal Blood Lead Levels and the Risk of Pregnancy-Induced Hypertension: The EDEN Cohort Study
- Author
-
Yazbeck, Chadi, Thiebaugeorges, Olivier, Moreau, Thierry, Goua, Valérie, Debotte, Ginette, Sahuquillo, Josiane, Forhan, Anne, Foliguet, Bernard, Magnin, Guillaume, Slama, Rémy, Charles, Marie-Aline, and Huel, Guy more...
- Published
- 2009
- Full Text
- View/download PDF
12. Maternal Personal Exposure to Airborne Benzene and Intrauterine Growth
- Author
-
EDEN Mother-Child Cohort Study Group, Slama, Rémy, Thiebaugeorges, Olivier, Goua, Valérie, Aussel, Lucette, Sacco, Paolo, Bohet, Aline, Forhan, Anne, Ducot, Béatrice, Annesi-Maesano, Isabella, Heinrich, Joachim, Magnin, Guillaume, Schweitzer, Michel, Kaminski, Monique, and Charles, Marie-Aline more...
- Published
- 2009
- Full Text
- View/download PDF
13. How to Control for Gestational Age in Studies Involving Environmental Effects on Fetal Growth
- Author
-
Slama, Rémy, Khoshnood, Babak, and Kaminski, Monique
- Published
- 2008
- Full Text
- View/download PDF
14. Prenatal Exposure to PM2.5 Oxidative Potential and Lung Function in Infants and Preschool- Age Children: A Prospective Study.
- Author
-
Marsal, Anouk, Slama, Rémy, Lyon-Caen, Sarah, S. Borlaza, Lucille Joanna, Jaffrezo, Jean-Luc, Boudier, Anne, Darfeuil, Sophie, Elazzouzi, Rhabira, Gioria, Yoann, Lepeule, Johanna, Chartier, Ryan, Pin, Isabelle, Quentin, Joane, Bayat, Sam, Uzu, Gaëlle, Siroux, Valérie, and the SEPAGES cohort study group more...
- Subjects
- *
LUNG physiology , *PARTICULATE matter , *MATERNAL exposure , *STATISTICS , *CONFIDENCE intervals , *MULTIPLE regression analysis , *PRENATAL exposure delayed effects , *PULMONARY function tests , *DESCRIPTIVE statistics , *RESEARCH funding , *BIOLOGICAL assay , *BREATH tests , *DATA analysis software , *OXIDATION-reduction reaction , *LONGITUDINAL method , *PREGNANCY - Abstract
BACKGROUND: Fine particulate matter (PM2.5) has been found to be detrimental to respiratory health of children, but few studies have examined the effects of prenatal PM2.5 oxidative potential (OP) on lung function in infants and preschool children. OBJECTIVES: We estimated the associations of personal exposure to PM2.5  and OP during pregnancy on offspring objective lung function parameters and compared the strengths of associations between both exposure metrics. METHODS: We used data from 356 mother–child pairs from the SEPAGES cohort. PM filters collected twice during a week were analyzed for OP, using the dithiothreitol (DTT) and the ascorbic acid (AA) assays, quantifying the exposure of each pregnant woman. Lung function was assessed with tidal breathing analysis (TBFVL) and nitrogen multiple-breath washout (N2MBW) test, performed at 6 wk, and airwave oscillometry (AOS) performed at 3 y. Associations of prenatal PM2.5  mass and OP with lung function parameters were estimated using multiple linear regressions. RESULTS: In neonates, an interquartile (IQR) increase in OPDTTv (0.89nmol/min/m³) was associated with a decrease in functional residual capacity (FRC) measured by N2MBW [β = -2.26 mL ; 95% confidence interval (CI): -4.68, 0.15]. Associations with PM2.5 showed similar patterns in comparison with OPDTTv but of smaller magnitude. Lung clearance index (LCI) and TBFVL parameters did not show any clear association with the exposures considered. At 3 y, increased frequency-dependent resistance of the lungs (Rrs7-19) from AOS tended to be associated with higher OPDTTv (β = 0.09hPa×s/L ; 95% CI: -0.06, 0.24) and OPAAv (IQR = 1.14nmol/min/m³ ; β = 0.12hPa×s/L ; 95% CI: -0.04, 0.27) but not with PM2.5 (IQR = 6.9µg/m³ ; β = 0.02hPa×s/L ; 95% CI: -0.13, 0.16). Results for FRC and Rrs7-19 remained similar in OP models adjusted on PM2.5. DISCUSSION: Prenatal exposure to OPDTTv was associated with several offspring lung function parameters over time, all related to lung volumes. [ABSTRACT FROM AUTHOR] more...
- Published
- 2023
- Full Text
- View/download PDF
15. Breast Cancer Risk in Association with Atmospheric Pollution Exposure: A Meta-Analysis of Effect Estimates Followed by a Health Impact Assessment
- Author
-
Gabet, Stephan, primary, Lemarchand, Clémentine, additional, Guénel, Pascal, additional, and Slama, Rémy, additional
- Published
- 2021
- Full Text
- View/download PDF
16. Early-Life Environmental Exposures and Childhood Obesity: An Exposome-Wide Approach
- Author
-
Vrijheid, Martine, primary, Fossati, Serena, additional, Maitre, Léa, additional, Márquez, Sandra, additional, Roumeliotaki, Theano, additional, Agier, Lydiane, additional, Andrusaityte, Sandra, additional, Cadiou, Solène, additional, Casas, Maribel, additional, de Castro, Montserrat, additional, Dedele, Audrius, additional, Donaire-Gonzalez, David, additional, Grazuleviciene, Regina, additional, Haug, Line S., additional, McEachan, Rosemary, additional, Meltzer, Helle Margrete, additional, Papadopouplou, Eleni, additional, Robinson, Oliver, additional, Sakhi, Amrit K., additional, Siroux, Valerie, additional, Sunyer, Jordi, additional, Schwarze, Per E., additional, Tamayo-Uria, Ibon, additional, Urquiza, Jose, additional, Vafeiadi, Marina, additional, Valentin, Antonia, additional, Warembourg, Charline, additional, Wright, John, additional, Nieuwenhuijsen, Mark J., additional, Thomsen, Cathrine, additional, Basagaña, Xavier, additional, Slama, Rémy, additional, and Chatzi, Leda, additional more...
- Published
- 2020
- Full Text
- View/download PDF
17. Challenges Raised by Mediation Analysis in a High-Dimension Setting
- Author
-
Blum, Michaël G.B., primary, Valeri, Linda, additional, François, Olivier, additional, Cadiou, Solène, additional, Siroux, Valérie, additional, Lepeule, Johanna, additional, and Slama, Rémy, additional more...
- Published
- 2020
- Full Text
- View/download PDF
18. Prenatal and Childhood Traffic-Related Air Pollution Exposure and Telomere Length in European Children: The HELIX Project
- Author
-
Clemente, Diana B.P., primary, Vrijheid, Martine, additional, Martens, Dries S., additional, Bustamante, Mariona, additional, Chatzi, Leda, additional, Danileviciute, Asta, additional, de Castro, Montserrat, additional, Grazuleviciene, Regina, additional, Gutzkow, Kristine B., additional, Lepeule, Johanna, additional, Maitre, Lea, additional, McEachan, Rosie R.C., additional, Robinson, Oliver, additional, Schwarze, Per E., additional, Tamayo, Ibon, additional, Vafeiadi, Marina, additional, Wright, John, additional, Slama, Rémy, additional, Nieuwenhuijsen, Mark, additional, and Nawrot, Tim S., additional more...
- Published
- 2019
- Full Text
- View/download PDF
19. Influence of the Urban Exposome on Birth Weight
- Author
-
Nieuwenhuijsen, Mark J., primary, Agier, Lydiane, additional, Basagaña, Xavier, additional, Urquiza, Jose, additional, Tamayo-Uria, Ibon, additional, Giorgis-Allemand, Lise, additional, Robinson, Oliver, additional, Siroux, Valérie, additional, Maitre, Léa, additional, de Castro, Montserrat, additional, Valentin, Antonia, additional, Donaire, David, additional, Dadvand, Payam, additional, Aasvang, Gunn Marit, additional, Krog, Norun Hjertager, additional, Schwarze, Per E., additional, Chatzi, Leda, additional, Grazuleviciene, Regina, additional, Andrusaityte, Sandra, additional, Dedele, Audrius, additional, McEachan, Rosie, additional, Wright, John, additional, West, Jane, additional, Ibarluzea, Jesús, additional, Ballester, Ferran, additional, Vrijheid, Martine, additional, and Slama, Rémy, additional more...
- Published
- 2019
- Full Text
- View/download PDF
20. Studying Human Fertility and Environmental Exposures
- Author
-
Slama, Rémy, Ducot, Béatrice, Keiding, Niels, and Bouyer, Jean
- Published
- 2004
21. Within-Day, Between-Day, and Between-Week Variability of Urinary Concentrations of Phenol Biomarkers in Pregnant Women
- Author
-
Vernet, Céline, primary, Philippat, Claire, additional, Calafat, Antonia M., additional, Ye, Xiaoyun, additional, Lyon-Caen, Sarah, additional, Siroux, Valérie, additional, Schisterman, Enrique F., additional, and Slama, Rémy, additional more...
- Published
- 2018
- Full Text
- View/download PDF
22. Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO 2 Air Pollution Exposure
- Author
-
Gruzieva, Olena, primary, Xu, Cheng-Jian, additional, Breton, Carrie V., additional, Annesi-Maesano, Isabella, additional, Antó, Josep M., additional, Auffray, Charles, additional, Ballereau, Stéphane, additional, Bellander, Tom, additional, Bousquet, Jean, additional, Bustamante, Mariona, additional, Charles, Marie-Aline, additional, de Kluizenaar, Yvonne, additional, den Dekker, Herman T., additional, Duijts, Liesbeth, additional, Felix, Janine F., additional, Gehring, Ulrike, additional, Guxens, Mònica, additional, Jaddoe, Vincent V.W., additional, Jankipersadsing, Soesma A., additional, Merid, Simon Kebede, additional, Kere, Juha, additional, Kumar, Ashish, additional, Lemonnier, Nathanael, additional, Lepeule, Johanna, additional, Nystad, Wenche, additional, Page, Christian Magnus, additional, Panasevich, Sviatlana, additional, Postma, Dirkje, additional, Slama, Rémy, additional, Sunyer, Jordi, additional, Söderhäll, Cilla, additional, Yao, Jin, additional, London, Stephanie J., additional, Pershagen, Göran, additional, Koppelman, Gerard H., additional, and Melén, Erik, additional more...
- Published
- 2017
- Full Text
- View/download PDF
23. Prenatal Exposure to Select Phthalates and Phenols and Associations with Fetal and Placental Weight among Male Births in the EDEN Cohort (France).
- Author
-
Philippat, Claire, Heude, Barbara, Botton, Jérémie, Alfaidy, Nadia, Calafat, Antonia M., and Slama, Rémy
- Subjects
BIOMARKERS ,BIRTH weight ,BODY weight ,CONFIDENCE intervals ,STATISTICAL correlation ,LONGITUDINAL method ,PHENOLS ,PLACENTA ,REGRESSION analysis ,RESEARCH funding ,STATISTICS ,URINALYSIS ,HYDROXY acids ,DATA analysis ,ENVIRONMENTAL exposure ,FETAL development ,CARBOCYCLIC acids ,TRICLOSAN ,DESCRIPTIVE statistics ,PRENATAL exposure delayed effects ,MATERNAL exposure - Abstract
BACKGROUND: The placenta performs crucial physiological functions to ensure normal fetal development. Few epidemiological studies investigated placental weight sensitivity to phthalates and phenols. OBJECTIVE: Our goal was to explore whether maternal exposure to select phthalates and phenols is associated with changes in placental weight at birth and in placental-to-birth weight ratio (PFR). METHODS: Placental weight and birth weight were available for 473 mother-son pairs in the EDEN (Etude des Déterminants pré et postnatals du développement et de la santé de l'Enfant) cohort for whom 9 phenols (4 parabens, 2 dichlorophenols, triclosan, benzophenone-3, bisphenol A) and 11 phthalate metabolites were measured in spot urine samples collected between weeks 23 and 29 of gestation. We used adjusted Elastic Net penalized regression models (ENET) to select biomarkers associated with placental weight, birth weight and PFR. Unpenalized effect estimates were then obtained by fitting linear regression models simultaneously adjusted for the ENET-selected biomarkers and a priori chosen confounders. RESULTS: The multipollutant ENET model for placental weight retained four biomarkers: triclosan and monocarboxy-isononyl phthalate (MCNP), which were negatively associated with placental weight, and benzophenone-3 and the sum of parabens, which were positively associated with this outcome. The ENET model for PFR retained two phthalate metabolites [MCNP and monocarboxy-isooctyl phthalate (MCOP)], which were negatively associated with this outcome. DISCUSSION: The positive association between the sum of parabens and placental weight was consistent with results of a previous study among 49 male births. Our results provide preliminary evidence of possible associations between other compounds such as triclosan, benzophenone-3, MCNP, and MCOP and both placental weight and PFR. These associations were not reported in previous studies and should be seen as hypothesis generating. Studies relying on repeated assessments of exposure in prospective mother-child cohorts are needed to substantiate the plausibility of the hypotheses generated by our results. [ABSTRACT FROM AUTHOR] more...
- Published
- 2019
- Full Text
- View/download PDF
24. A Systematic Comparison of Linear Regression–Based Statistical Methods to Assess Exposome-Health Associations
- Author
-
Agier, Lydiane, primary, Portengen, Lützen, additional, Chadeau-Hyam, Marc, additional, Basagaña, Xavier, additional, Giorgis-Allemand, Lise, additional, Siroux, Valérie, additional, Robinson, Oliver, additional, Vlaanderen, Jelle, additional, González, Juan R., additional, Nieuwenhuijsen, Mark J., additional, Vineis, Paolo, additional, Vrijheid, Martine, additional, Slama, Rémy, additional, and Vermeulen, Roel, additional more...
- Published
- 2016
- Full Text
- View/download PDF
25. Scientific Issues Relevant to Setting Regulatory Criteria to Identify Endocrine-Disrupting Substances in the European Union
- Author
-
Slama, Rémy, primary, Bourguignon, Jean-Pierre, additional, Demeneix, Barbara, additional, Ivell, Richard, additional, Panzica, Giancarlo, additional, Kortenkamp, Andreas, additional, and Zoeller, R. Thomas, additional more...
- Published
- 2016
- Full Text
- View/download PDF
26. Air Pollution Exposure during Pregnancy and Childhood Autistic Traits in Four European Population-Based Cohort Studies: The ESCAPE Project
- Author
-
Guxens, Mònica, primary, Ghassabian, Akhgar, additional, Gong, Tong, additional, Garcia-Esteban, Raquel, additional, Porta, Daniela, additional, Giorgis-Allemand, Lise, additional, Almqvist, Catarina, additional, Aranbarri, Aritz, additional, Beelen, Rob, additional, Badaloni, Chiara, additional, Cesaroni, Giulia, additional, de Nazelle, Audrey, additional, Estarlich, Marisa, additional, Forastiere, Francesco, additional, Forns, Joan, additional, Gehring, Ulrike, additional, Ibarluzea, Jesús, additional, Jaddoe, Vincent W.V., additional, Korek, Michal, additional, Lichtenstein, Paul, additional, Nieuwenhuijsen, Mark J., additional, Rebagliato, Marisa, additional, Slama, Rémy, additional, Tiemeier, Henning, additional, Verhulst, Frank C., additional, Volk, Heather E., additional, Pershagen, Göran, additional, Brunekreef, Bert, additional, and Sunyer, Jordi, additional more...
- Published
- 2016
- Full Text
- View/download PDF
27. In Utero Exposure to Select Phenols and Phthalates and Respiratory Health in Five-Year-Old Boys: A Prospective Study.
- Author
-
Vernet, Céline, Pin, Isabelle, Giorgis-Allemand, Lise, Philippat, Claire, Benmerad, Meriem, Quentin, Joane, Calafat, Antonia M., Xiaoyun Ye, Annesi-Maesano, Isabella, Siroux, Valérie, and Slama, Rémy
- Abstract
BACKGROUND: Phenols and phthalates may have immunomodulatory and proinflammatory effects and thereby adversely affect respiratory health. OBJECTIVE: We estimated the associations between gestational exposure to select phthalates and phenols and respiratory health in boys. METHODS: Among 587 pregnant women from the EDEN (Etude des Déterminants pré et post natals du développement et de la santé de l’Enfant) cohort who delivered a boy, 9 phenols and 11 phthalates metabolites were quantified in spot pregnancy urine samples. Respiratory outcomes were followed up by questionnaires until age 5, when forced expiratory volume in 1 s (FEV
1 ) was measured by spirometry. Adjusted associations of urinary metabolites log–transformed concentrations with respiratory outcomes and FEV1 in percent predicted (FEV1 %) were estimated by survival and linear regression models, respectively. RESULTS: No phenol or phthalate metabolite exhibited clear deleterious associations simultaneously with several respiratory outcomes. Ethyl-paraben was associated with increased asthma rate [hazard rate (HR)=1.10; 95% confidence interval (CI): 1.00, 1.21] and tended to be negatively associated with FEV1 % (beta=−0.59; 95% CI: −1.24, 0.05); bisphenol A tended to be associated with increased rates of asthma diagnosis (HR=1.23; 95% CI: 0.97, 1.55) and bronchiolitis/bronchitis (HR=1.13; 95% CI: 0.99, 1.30). Isolated trends for deleterious associations were also observed between 2,5-dichlorophenol and wheezing, and between monocarboxynonyl phthalate, a metabolite of di-isodecyl phthalate (DIDP), and wheezing. CONCLUSION: Ethyl-paraben, bisphenol A, 2,5-dichlorophenol, and DIDP tended to be associated with altered respiratory health, with ethyl-paraben and bisphenol A exhibiting some consistency across respiratory outcomes. The trends between bisphenol A pregnancy level and increased asthma and bronchiolitis/bronchitis rates in childhood were consistent with a previous cohort study. [ABSTRACT FROM AUTHOR] more...- Published
- 2017
- Full Text
- View/download PDF
28. Prenatal Exposure to Nonpersistent Endocrine Disruptors and Behavior in Boys at 3 and 5 Years.
- Author
-
Philippat, Claire, Nakiwala, Dorothy, Calafat, Antonia M., Botton, Jérémie, De Agostini, Maria, Heude, Barbara, and Slama, Rémy
- Subjects
BEHAVIOR disorders in children ,BIOMARKERS ,CONFIDENCE intervals ,LONGITUDINAL method ,PHENOLS ,POLLUTANTS ,PROBABILITY theory ,QUESTIONNAIRES ,REGRESSION analysis ,RESEARCH funding ,STATISTICS ,DATA analysis ,ENVIRONMENTAL exposure ,DATA analysis software ,DESCRIPTIVE statistics ,INTRACLASS correlation ,PREGNANCY - Abstract
BACKGROUND: Sex-specific associations have been reported between phthalates, bisphenol A (BPA), and child behavior. No data on large study populations are available for other phenols with possible endocrine-disrupting properties. OBJECTIVES: We aimed to study associations between prenatal exposure to phthalates and several phenols on behavior among male infants. METHODS: We quantified 11 phthalate metabolites and nine phenols (four parabens, benzophenone-3, BPA, two dichlorophenols, triclosan) in spot urine samples collected during pregnancy among EDEN cohort mothers who delivered a boy. Mothers completed the Strength and Difficulties Questionnaire (SDQ) when their children were 3.1 (n=529) and 5.6 (n=464) y old. RESULTS: BPA was positively associated with the relationship problems subscale at 3 y [incidence rate ratio (IRR): 1.11; 95% confidence interval (CI): 1.03, 1.20] and the hyperactivity-inattention subscale scores at 5 y (IRR: 1.08; 95% CI: 1.01, 1.14). Mono-n-butyl phthalate (MnBP) was positively associated with internalizing behavior, relationship problem, and emotional symptom scores at 3 y. Monobenzyl phthalate (MBzP) was positively associated with internalizing behavior and relationship problems scores at 3 y. After dichotomizing SDQ scores, triclosan tended to be positively associated with emotional symptom subscales at both 3 and 5 y. CONCLUSIONS: The observed associations between BPA, MnBP, and behavior in boys are consistent with previous findings. Further health impact assessment studies based on dose-response functions corrected for exposure misclassification are required to quantify the public health burden possibly entailed by such associations. [ABSTRACT FROM AUTHOR] more...
- Published
- 2017
- Full Text
- View/download PDF
29. The Human Early-Life Exposome (HELIX): Project Rationale and Design
- Author
-
Vrijheid, Martine, primary, Slama, Rémy, additional, Robinson, Oliver, additional, Chatzi, Leda, additional, Coen, Muireann, additional, van den Hazel, Peter, additional, Thomsen, Cathrine, additional, Wright, John, additional, Athersuch, Toby J., additional, Avellana, Narcis, additional, Basagaña, Xavier, additional, Brochot, Celine, additional, Bucchini, Luca, additional, Bustamante, Mariona, additional, Carracedo, Angel, additional, Casas, Maribel, additional, Estivill, Xavier, additional, Fairley, Lesley, additional, van Gent, Diana, additional, Gonzalez, Juan R., additional, Granum, Berit, additional, Gražulevicˇiene˙, Regina, additional, Gutzkow, Kristine B., additional, Julvez, Jordi, additional, Keun, Hector C., additional, Kogevinas, Manolis, additional, McEachan, Rosemary R.C., additional, Meltzer, Helle Margrete, additional, Sabidó, Eduard, additional, Schwarze, Per E., additional, Siroux, Valérie, additional, Sunyer, Jordi, additional, Want, Elizabeth J., additional, Zeman, Florence, additional, and Nieuwenhuijsen, Mark J., additional more...
- Published
- 2014
- Full Text
- View/download PDF
30. Prenatal Exposure to Environmental Phenols: Concentrations in Amniotic Fluid and Variability in Urinary Concentrations during Pregnancy
- Author
-
Philippat, Claire, primary, Wolff, Mary S., additional, Calafat, Antonia M., additional, Ye, Xiaoyun, additional, Bausell, Rebecca, additional, Meadows, Molly, additional, Stone, Joanne, additional, Slama, Rémy, additional, and Engel, Stephanie M., additional more...
- Published
- 2013
- Full Text
- View/download PDF
31. Impact of Geocoding Methods on Associations between Long-term Exposure to Urban Air Pollution and Lung Function
- Author
-
Jacquemin, Bénédicte, primary, Lepeule, Johanna, additional, Boudier, Anne, additional, Arnould, Caroline, additional, Benmerad, Meriem, additional, Chappaz, Claire, additional, Ferran, Joane, additional, Kauffmann, Francine, additional, Morelli, Xavier, additional, Pin, Isabelle, additional, Pison, Christophe, additional, Rios, Isabelle, additional, Temam, Sofia, additional, Künzli, Nino, additional, Slama, Rémy, additional, and Siroux, Valérie, additional more...
- Published
- 2013
- Full Text
- View/download PDF
32. Maternal Exposure to Particulate Air Pollution and Term Birth Weight: A Multi-Country Evaluation of Effect and Heterogeneity
- Author
-
Dadvand, Payam, primary, Parker, Jennifer, additional, Bell, Michelle L., additional, Bonzini, Matteo, additional, Brauer, Michael, additional, Darrow, Lyndsey A., additional, Gehring, Ulrike, additional, Glinianaia, Svetlana V., additional, Gouveia, Nelson, additional, Ha, Eun-hee, additional, Leem, Jong Han, additional, van den Hooven, Edith H., additional, Jalaludin, Bin, additional, Jesdale, Bill M., additional, Lepeule, Johanna, additional, Morello-Frosch, Rachel, additional, Morgan, Geoffrey G., additional, Pesatori, Angela Cecilia, additional, Pierik, Frank H., additional, Pless-Mulloli, Tanja, additional, Rich, David Q., additional, Sathyanarayana, Sheela, additional, Seo, Juhee, additional, Slama, Rémy, additional, Strickland, Matthew, additional, Tamburic, Lillian, additional, Wartenberg, Daniel, additional, Nieuwenhuijsen, Mark J., additional, and Woodruff, Tracey J., additional more...
- Published
- 2013
- Full Text
- View/download PDF
33. Maternal Exposure to Nitrogen Dioxide during Pregnancy and Offspring Birth Weight: Comparison of Two Exposure Models
- Author
-
Lepeule, Johanna, primary, Caïni, Fabrice, additional, Bottagisi, Sébastien, additional, Galineau, Julien, additional, Hulin, Agnès, additional, Marquis, Nathalie, additional, Bohet, Aline, additional, Siroux, Valérie, additional, Kaminski, Monique, additional, Charles, Marie-Aline, additional, Slama, Rémy, additional, and Group, the EDEN Mother–Child Cohort Study, additional more...
- Published
- 2010
- Full Text
- View/download PDF
34. Birth Weight and Prenatal Exposure to Polychlorinated Biphenyls (PCBs) and Dichlorodiphenyldichloroethylene (DDE): A Meta-analysis within 12 European Birth Cohorts.
- Author
-
Govarts, Eva, Nieuwenhuijsen, Mark, Schoeters, Greet, Ballester, Ferrari, Bloemen, Karolien, Boer, Michiel de, Chevrier, Cécile, Eggesbø, Merete, Guxens, Mònica, Krämer, Ursula, Legler, Juliette, Martínez, David, Palkovicova, Lubica, Patelarou, Evridiki, Ranft, Ulrich, Rautio, Arja, Petersen, Maria Skaalum, Slama, Rémy, Stigum, Hein, and Toft, Gunnar more...
- Subjects
ANALYSIS of covariance ,BIOMARKERS ,BIRTH weight ,BLOOD testing ,BREAST milk ,CONFIDENCE intervals ,CORD blood ,GESTATIONAL age ,HYDROCARBONS ,LONGITUDINAL method ,META-analysis ,POLYCHLORINATED biphenyls ,PREGNANT women ,REGRESSION analysis ,RESEARCH funding ,ENVIRONMENTAL exposure ,DATA analysis software ,DESCRIPTIVE statistics ,FETUS ,PREGNANCY - Abstract
OBJECTIVES: Exposure to high concentrations of persistent organochlorines may cause fetal toxicity, but the evidence at low exposure levels is limited. Large studies with substantial exposure contrasts and appropriate exposure assessment are warranted. Within the framework of the EU (European Union) ENRIECO (ENvironmental Health RIsks in European Birth Cohorts) and EU OBELIX (OBesogenic Endocrine disrupting chemicals: LInking prenatal eXposure to the development of obesity later in life) projects, we examined the hypothesis that the combination of polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) adversely affects birth weight. METHODS: We used maternal and cord blood and breast milk samples of 7,990 women enrolled in 15 study populations from 12 European birth cohorts from 1990 through 2008. Using identical variable definitions, we performed for each cohort linear regression of birth weight on estimates of cord serum concentration of PCB-153 and p,p′-DDE adjusted for gestational age and a priori selected covariates. We obtained summary estimates by meta-analysis and performed analyses of interactions. RESULTS: The median concentration of cord serum PCB-153 was 140 ng/L (range of cohort medians 20-484 ng/L) and that of p,p′-DDE was 528 ng/L (range of cohort medians 50-1,208 ng/L). Birth weight decreased with increasing cord serum concentration of PCB-153 after adjustment for potential confounders in 12 of 15 study populations. The meta-analysis including all cohorts indicated a birth weight decline of 150 g [95% confidence interval (CI): -250, -50 g] per 1-µg/L increase in PCB-153, an exposure contrast that is close to the range of exposures across the cohorts. A 1-µg/L increase in p,p′-DDE was associated with a 7-g decrease in birth weight (95% CI: -18, 4 g). CONCLUSIONS: The findings suggest that low-level exposure to PCB (or correlated exposures) impairs fetal growth, but that exposure to p,p′-DDE does not. The study adds to mounting evidence that low-level exposure to PCBs is inversely associated with fetal growth. [ABSTRACT FROM AUTHOR] more...
- Published
- 2012
- Full Text
- View/download PDF
35. Maternal Personal Exposure to Airborne Benzene and Intrauterine Growth.
- Author
-
Slama, Rémy, Thiebaugeorges, Olivier, Goua, Valérie, Aussel, Lucette, Sacco, Paolo, Bohet, Aline, Forhan, Anne, Ducot, Béatrice, Annesi-Maesano, Isabella, Heinrich, Joachim, Magnin, Guillaume, Schweitzer, Michel, Kaminski, Monique, and Charles, Marie-Aline more...
- Subjects
- *
PREGNANCY complications , *BENZENE , *AIR pollution , *FETAL development , *BIRTH weight , *PREGNANT women , *POLLUTANTS , *LONGITUDINAL method - Abstract
Background: Studies relying on outdoor pollutants measures have reported associations between air pollutants and birth weight. Objective: Our aim was to assess the relation between maternal personal exposure to airborne benzene during pregnancy and fetal growth. Methods: We recruited pregnant women in two French maternity hospitals in 2005-2006 as part of the EDEN mother-child cohort. A subsample of 271 nonsmoking women carried a diffusive air sampler for a week during the 27th gestational week, allowing assessment of benzene exposure. We estimated head circumference of the offspring by ultrasound measurements during the second and third trimesters of pregnancy and at birth. Results: Median benzene exposure was 1.8 μg/m3 (5th, 95th percentiles, 0.5, 7.5 μg/m3). Logtransformed benzene exposure was associated with a gestational age—adjusted decrease of 68 g in mean birth weight [95% confidence interval (CI), —135 to —1 g] and of 1.9 mm in mean head circumference at birth (95% CI, —3.8 to 0.0 mm). It was associated with an adjusted decrease of 1.9 mm in head circumference assessed during the third trimester (95% CI, —4.0 to 0.3 mm) and of 1.5 mm in head circumference assessed at the end of the second trimester of pregnancy (95% CI, —3.1 to 0 mm). Conclusions: Our prospective study among pregnant women is one of the first to rely on personal monitoring of exposure; a limitation is that exposure was assessed during 1 week only. Maternal benzene exposure was associated with decreases in birth weight and head circumference during pregnancy and at birth. This association could be attributable to benzene and a mixture of associated traffic-related air pollutants. [ABSTRACT FROM AUTHOR] more...
- Published
- 2009
- Full Text
- View/download PDF
36. Prenatal Exposure to P M 2.5 Oxidative Potential and Lung Function in Infants and Preschool- Age Children: A Prospective Study.
- Author
-
Marsal A, Slama R, Lyon-Caen S, Borlaza LJS, Jaffrezo JL, Boudier A, Darfeuil S, Elazzouzi R, Gioria Y, Lepeule J, Chartier R, Pin I, Quentin J, Bayat S, Uzu G, and Siroux V
- Subjects
- Infant, Newborn, Female, Pregnancy, Humans, Infant, Child, Preschool, Prospective Studies, Environmental Exposure analysis, Particulate Matter toxicity, Particulate Matter analysis, Lung, Oxidative Stress, Air Pollutants toxicity, Air Pollutants analysis, Prenatal Exposure Delayed Effects epidemiology, Air Pollution adverse effects, Air Pollution analysis
- Abstract
Background: Fine particulate matter ( PM 2.5 ) has been found to be detrimental to respiratory health of children, but few studies have examined the effects of prenatal PM 2.5 oxidative potential (OP) on lung function in infants and preschool children., Objectives: We estimated the associations of personal exposure to PM 2.5 and OP during pregnancy on offspring objective lung function parameters and compared the strengths of associations between both exposure metrics., Methods: We used data from 356 mother-child pairs from the SEPAGES cohort. PM filters collected twice during a week were analyzed for OP, using the dithiothreitol (DTT) and the ascorbic acid (AA) assays, quantifying the exposure of each pregnant woman. Lung function was assessed with tidal breathing analysis (TBFVL) and nitrogen multiple-breath washout ( N 2 MBW ) test, performed at 6 wk, and airwave oscillometry (AOS) performed at 3 y. Associations of prenatal PM 2.5 mass and OP with lung function parameters were estimated using multiple linear regressions., Results: In neonates, an interquartile (IQR) increase in OP v DTT ( 0.89 nmol / min / m 3 ) was associated with a decrease in functional residual capacity (FRC) measured by N 2 MBW [ β = - 2.26 mL ; 95% confidence interval (CI): - 4.68 , 0.15]. Associations with PM 2.5 showed similar patterns in comparison with OP v DTT but of smaller magnitude. Lung clearance index (LCI) and TBFVL parameters did not show any clear association with the exposures considered. At 3 y, increased frequency-dependent resistance of the lungs ( Rrs 7 - 19 ) from AOS tended to be associated with higher OP v DTT ( β = 0.09 hPa × s / L ; 95% CI: - 0.06 , 0.24) and OP v AA ( IQR = 1.14 nmol / min / m 3 ; β = 0.12 hPa × s / L ; 95% CI: - 0.04 , 0.27) but not with PM 2.5 ( IQR = 6.9 μ g / m 3 ; β = 0.02 hPa × s / L ; 95% CI: - 0.13 , 0.16). Results for FRC and Rrs 7 - 19 remained similar in OP models adjusted on PM 2.5 ., Discussion: Prenatal exposure to OP v DTT was associated with several offspring lung function parameters over time, all related to lung volumes. https://doi.org/10.1289/EHP11155. more...
- Published
- 2023
- Full Text
- View/download PDF
37. Exposure to Bisphenol A and Bisphenol S and Incident Type 2 Diabetes: A Case-Cohort Study in the French Cohort D.E.S.I.R.
- Author
-
Rancière F, Botton J, Slama R, Lacroix MZ, Debrauwer L, Charles MA, Roussel R, Balkau B, and Magliano DJ
- Subjects
- Adult, Benzhydryl Compounds toxicity, Cohort Studies, Environmental Pollutants toxicity, Female, France epidemiology, Humans, Incidence, Male, Phenols toxicity, Risk Factors, Sulfones toxicity, Benzhydryl Compounds metabolism, Diabetes Mellitus, Type 2 epidemiology, Environmental Exposure statistics & numerical data, Environmental Pollutants metabolism, Phenols metabolism, Sulfones metabolism
- Abstract
Background: The question of whether exposure to bisphenol A (BPA) contributes to the development of type 2 diabetes is still unresolved. Most epidemiological evidence on the association between BPA and diabetes is from cross-sectional studies or longitudinal studies with single urinary measurements. No prospective study has examined exposure to BPA analogs such as bisphenol S (BPS) in relation to incident type 2 diabetes., Objectives: We aimed to investigate whether exposure to BPA and BPS, assessed at up to two time points, was associated with the incidence of type 2 diabetes., Methods: We performed a case-cohort study on 755 participants without diabetes at baseline and followed-up over 9 y as part of the French prospective cohort Data from an Epidemiological Study on the Insulin Resistance Syndrome (D.E.S.I.R.). BPA-glucuronide (BPA-G) and BPS-glucuronide (BPS-G) were assessed in fasting spot urine samples collected during the health examinations at baseline and 3 y later. Associations with incident diabetes were examined using Prentice-weighted Cox regression models adjusted for potential confounders., Results: A total of 201 incident cases of type 2 diabetes were diagnosed over the follow-up, including 30 in the subcohort. Compared with participants with the lowest average BPA exposure (below the first quartile), participants in the second, third, and fourth quartile groups of exposure had a near doubling of the risk of type 2 diabetes, with a hazard ratio ( HR ) = 2.56 (95% CI: 1.16, 5.65), 2.35 (95% CI: 1.07, 5.15), and 1.56 (95% CI: 0.68, 3.55), respectively. The detection of BPS-G in urine at one or both time points was associated with incident diabetes, with an HR = 2.81 (95% CI: 1.74, 4.53)., Discussion: This study shows positive associations between exposure to BPA and BPS and the incidence of type 2 diabetes, independent of traditional diabetes risk factors. Our results should be confirmed by recent, population-based observational studies in different populations and settings. Overall, these findings raise concerns about using BPS as a BPA substitute. Further research on BPA analogs is warranted. https://doi.org/10.1289/EHP5159. more...
- Published
- 2019
- Full Text
- View/download PDF
38. Erratum: "Prenatal Exposure to Nonpersistent Endocrine Disruptors and Behavior in Boys at 3 and 5 Years".
- Author
-
Philippat C, Nakiwala D, Calafat AM, Botton J, De Agostini M, Heude B, and Slama R
- Published
- 2018
- Full Text
- View/download PDF
39. Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure.
- Author
-
Gruzieva O, Xu CJ, Breton CV, Annesi-Maesano I, Antó JM, Auffray C, Ballereau S, Bellander T, Bousquet J, Bustamante M, Charles MA, de Kluizenaar Y, den Dekker HT, Duijts L, Felix JF, Gehring U, Guxens M, Jaddoe VV, Jankipersadsing SA, Merid SK, Kere J, Kumar A, Lemonnier N, Lepeule J, Nystad W, Page CM, Panasevich S, Postma D, Slama R, Sunyer J, Söderhäll C, Yao J, London SJ, Pershagen G, Koppelman GH, and Melén E more...
- Subjects
- Child, Female, Humans, Infant, Newborn, London, Pregnancy, Air Pollutants analysis, Air Pollution statistics & numerical data, DNA Methylation, Maternal Exposure statistics & numerical data, Nitrogen Dioxide analysis, Prenatal Exposure Delayed Effects epidemiology
- Abstract
Background: Prenatal exposure to air pollution is considered to be associated with adverse effects on child health. This may partly be mediated by mechanisms related to DNA methylation., Objectives: We investigated associations between exposure to air pollution, using nitrogen dioxide (NO2) as marker, and epigenome-wide cord blood DNA methylation., Methods: We meta-analyzed the associations between NO2 exposure at residential addresses during pregnancy and cord blood DNA methylation (Illumina 450K) in four European and North American studies (n = 1,508) with subsequent look-up analyses in children ages 4 (n = 733) and 8 (n = 786) years. Additionally, we applied a literature-based candidate approach for antioxidant and anti-inflammatory genes. To assess influence of exposure at the transcriptomics level, we related mRNA expression in blood cells to NO2 exposure in 4- (n = 111) and 16-year-olds (n = 239)., Results: We found epigenome-wide significant associations [false discovery rate (FDR) p < 0.05] between maternal NO2 exposure during pregnancy and DNA methylation in newborns for 3 CpG sites in mitochondria-related genes: cg12283362 (LONP1), cg24172570 (3.8 kbp upstream of HIBADH), and cg08973675 (SLC25A28). The associations with cg08973675 methylation were also significant in the older children. Further analysis of antioxidant and anti-inflammatory genes revealed differentially methylated CpGs in CAT and TPO in newborns (FDR p < 0.05). NO2 exposure at the time of biosampling in childhood had a significant impact on CAT and TPO expression., Conclusions: NO2 exposure during pregnancy was associated with differential offspring DNA methylation in mitochondria-related genes. Exposure to NO2 was also linked to differential methylation as well as expression of genes involved in antioxidant defense pathways. Citation: Gruzieva O, Xu CJ, Breton CV, Annesi-Maesano I, Antó JM, Auffray C, Ballereau S, Bellander T, Bousquet J, Bustamante M, Charles MA, de Kluizenaar Y, den Dekker HT, Duijts L, Felix JF, Gehring U, Guxens M, Jaddoe VV, Jankipersadsing SA, Merid SK, Kere J, Kumar A, Lemonnier N, Lepeule J, Nystad W, Page CM, Panasevich S, Postma D, Slama R, Sunyer J, Söderhäll C, Yao J, London SJ, Pershagen G, Koppelman GH, Melén E. 2017. Epigenome-wide meta-analysis of methylation in children related to prenatal NO2 air pollution exposure. Environ Health Perspect 125:104-110; http://dx.doi.org/10.1289/EHP36., Competing Interests: The authors declare they have no actual or potential competing financial interests. more...
- Published
- 2017
- Full Text
- View/download PDF
40. Elemental Constituents of Particulate Matter and Newborn's Size in Eight European Cohorts.
- Author
-
Pedersen M, Gehring U, Beelen R, Wang M, Giorgis-Allemand L, Andersen AM, Basagaña X, Bernard C, Cirach M, Forastiere F, de Hoogh K, Gražulevičvienė R, Gruzieva O, Hoek G, Jedynska A, Klümper C, Kooter IM, Krämer U, Kukkonen J, Porta D, Postma DS, Raaschou-Nielsen O, van Rossem L, Sunyer J, Sørensen M, Tsai MY, Vrijkotte TG, Wilhelm M, Nieuwenhuijsen MJ, Pershagen G, Brunekreef B, Kogevinas M, and Slama R more...
- Subjects
- Air Pollutants toxicity, Birth Weight drug effects, Copper toxicity, Humans, Infant, Newborn, Iron toxicity, Nickel toxicity, Silicon toxicity, Sulfur toxicity, Zinc toxicity, Particulate Matter toxicity
- Abstract
Background: The health effects of suspended particulate matter (PM) may depend on its chemical composition. Associations between maternal exposure to chemical constituents of PM and newborn's size have been little examined., Objective: We aimed to investigate the associations of exposure to elemental constituents of PM with term low birth weight (LBW; weight < 2,500 g among births after 37 weeks of gestation), mean birth weight, and head circumference, relying on standardized fine-scale exposure assessment and with extensive control for potential confounders., Methods: We pooled data from eight European cohorts comprising 34,923 singleton births in 1994-2008. Annual average concentrations of elemental constituents of PM ≤ 2.5 and ≤ 10 μm (PM2.5 and PM10) at maternal home addresses during pregnancy were estimated using land-use regression models. Adjusted associations between each birth measurement and concentrations of eight elements (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) were calculated using random-effects regression on pooled data., Results: A 200-ng/m3 increase in sulfur in PM2.5 was associated with an increased risk of LBW (adjusted odds ratio = 1.36; 95% confidence interval: 1.17, 1.58). Increased nickel and zinc in PM2.5 concentrations were also associated with an increased risk of LBW. Head circumference was reduced at higher exposure to all elements except potassium. All associations with sulfur were most robust to adjustment for PM2.5 mass concentration. All results were similar for PM10., Conclusion: Sulfur, reflecting secondary combustion particles in this study, may adversely affect LBW and head circumference, independently of particle mass., Citation: Pedersen M, Gehring U, Beelen R, Wang M, Giorgis-Allemand L, Andersen AM, Basagaña X, Bernard C, Cirach M, Forastiere F, de Hoogh K, Gražulevičienė R, Gruzieva O, Hoek G, Jedynska A, Klümper C, Kooter IM, Krämer U, Kukkonen J, Porta D, Postma DS, Raaschou-Nielsen O, van Rossem L, Sunyer J, Sørensen M, Tsai MY, Vrijkotte TG, Wilhelm M, Nieuwenhuijsen MJ, Pershagen G, Brunekreef B, Kogevinas M, Slama R. 2016. Elemental constituents of particulate matter and newborn's size in eight European cohorts. Environ Health Perspect 124:141-150; http://dx.doi.org/10.1289/ehp.1409546. more...
- Published
- 2016
- Full Text
- View/download PDF
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.