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Understanding the spatiotemporal relationships between land use/cover changes (LUCC) and groundwater resources is necessary for effective and efficient land use management. In this paper, geographically weighted regression (GWR) and ordinary least squares (OLS) models have been expanded to analyze varying spatial relationships between groundwater quantity changes and LUCC for three periods: 1987-2000, 2000-2010, and 1987-2010 in the Khanmirza Plain of southwestern Iran. For this purpose, TM images were used to generate LUCC (rainfed, irrigated, meadow, and bare lands). Groundwater quantity variables, including groundwater level changes (GLC) and groundwater withdrawal differences (GWD), were gathered from piezometric and agricultural wells data. The analysis of spatial autocorrelation (Moran's I and local indicators of spatial association ) demonstrated that GWR has a better ability to model spatially varying data with very minimal clustering of residuals. The results R and corrected Akaike's Information Criterion parameters revealed that the GWR has the lowest similarity in space and time in neighboring situations and it has the high ability to explain more variance in the LUCC as a function of the groundwater quantity changes. All results of the distribution of local R values from GWR confirm our assertion that there is a spatiotemporal relationship between types of land use and each of groundwater quantity variables within the region. According to the t test results from GWR, there are significant differences between the GLC and GWD and the land use types in different places of region in each of the three time series. The GWR results can help decision-makers to make appropriate decisions for future planning. [ABSTRACT FROM AUTHOR]